Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute

Wokovich, Anna M.; Prodduturi, Suneela; Doub, William H.; Hussain, Ajaz; Buhse, Lucinda F.

doi:10.1016/j.ejpb.2006.03.009

Cited by 254 publications

(158 citation statements)

References 23 publications

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“…Acrylate polymers are well known skin adhesives [29,30,65]. Our films are composed of chitosan and a PAA but the amount of PAA is only approximately one third of the total polymer weight, a fact that justifies the small values measured for the PAF and WA, see Table 2.…”

Section: Bioadhesionmentioning

confidence: 92%

“…Skin adhesion is one of the most important functional properties for a skin drug delivery system [29] and should be evaluated in all formulations in development for this purpose. The in vitro conditions do not represent the performance of a film under in vivo conditions due to skin properties, such as moisture and elasticity that are not possible to reproduce in the in vitro test.…”

Section: Bioadhesionmentioning

confidence: 99%

“…The in vitro conditions do not represent the performance of a film under in vivo conditions due to skin properties, such as moisture and elasticity that are not possible to reproduce in the in vitro test. Most of the in vivo bioadhesive tests are based on subjective observations resorting to scoring systems [29,64]. We use skin in vivo as the substrate for testing adhesive properties and a quantitative evaluation is made by measuring the peak adhesion force and the work of adhesion.…”

Section: Bioadhesionmentioning

confidence: 99%

“…For this purpose the delivery system is required to be bioadhesive [29,30]. This would allow an intimate and prolonged contact with the skin in the application site so as to provide a continuous drug supply as well as flexibility and elasticity sufficient to follow the movements of the skin and provide a good feel.…”

Section: Introductionmentioning

confidence: 99%

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Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Silva

Pereira

Ramalho

et al. 2008

Journal of Membrane Science

116

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a b s t r a c tNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pK a of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.The optimized film, including adhesive, has shown very good properties for application in the skin and represents a very promising formulation for further incorporation of drugs for topical and transdermal administration.

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Section: Bioadhesionmentioning

confidence: 92%

Section: Bioadhesionmentioning

confidence: 99%

Section: Bioadhesionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations