Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding

Abstract

Graphical abstract

Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases

“…Several substances were already successfully delivered using this system by enabling the transdermal delivery of drugs that can be absorbed directly into the systemic circulation [185][186][187][188]. A recent study was developed to investigate the production of microneedles for the delivery of vitamin K [189]. The in vitro results showed that vitamin K in a microneedle array was successfully delivered in neonatal porcine skin over 24 h. This methodology, even though it still needs to be clinically validated, anticipates great potential for improvement of patient compliance in vitamin K prophylaxis in developed countries and might contribute to reduce VKDB cases in undeveloped countries [189].…”

Innate local response and tissue recovery following application of high density microarray patches to human skin

“…Microneedle arrays have a wide range of uses from cosmetic 14 , 15 (e.g. Dermaroller™), diagnostic 16 , 17 , drug delivery 18 – 20 through to the most promising and most studied area, vaccine delivery 21 . In small animal models comparative dose matched studies with standard injection methods, HD-MAPs have routinely been shown to produce enhanced immune responses with enhanced kinetics of IgG induction with a fractional dose compared to needle and syringe for a wide range of vaccines from inactivated virus 22 , 23 , split virus 24 , conjugated 25 , DNA 26 and virus like particle vaccines 27 .…”

Influence of molecular weight on transdermal delivery of model macromolecules using hydrogel-forming microneedles: potential to enhance the administration of novel low molecular weight biotherapeutics

“…Dissolving MNs have been tested with therapeutics possessing a wide range of solubilities and MWs. 15,[34][35][36][37] This delivery system has shown to be of considerable interest in bolus dosing due to the short dissolution time of the needle tips. In particular, corium have manufactured a drug-in tip dissolving MN containing teriparatide, a recombinant human parathyroid hormone indicated in osteoporosis which has successfully completed Phase 2a clinical trials.…”

“…1,13,14 With the potential for needle stick injuries, needle phobia and the necessity for dedicated sharps disposal, there is a need to develop new delivery systems to eliminate these costly obstacles. 15 A possible alternative are hydrogel-forming microneedles (MN) which consist of drug-free, micron scale polymeric needles situated in perpendicular orientation on a base plate to which a separate drug containing reservoir is attached. Following pain-free application to the skin, these MNs imbibe interstitial skin fluid and swell, creating micro-conduits within the skin layers to permit drug delivery into the dermal micro-circulation.…”