Transdermal Delivery of Peptides and Proteins

Herwadkar, Anushree; Banga, Ajay K.

doi:10.1016/b978-0-12-384935-9.10004-5

Cited by 11 publications

(10 citation statements)

References 47 publications

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“…Moreover, skin is easily accessible and delivery can be controlled and terminated whenever required. However, transdermal protein and peptide delivery is limited by penetrative and enzymatic barriers [161]. Large size and hydrophilic nature forbid the passive diffusion of proteins across the skin.…”

Section: Transdermal Deliverymentioning

confidence: 99%

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Patel¹,

Patel²,

Yang³

et al. 2014

PPL

167

101

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Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly employed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, pulmonary, and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations.

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Section: Transdermal Deliverymentioning

confidence: 99%

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Patel¹,

Patel²,

Yang³

et al. 2014

PPL

167

101

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“…However, the physicochemical properties of peptides -high molecular weight, charge at physiological pH and hydrophilic nature -render them inappropriate for passive transdermal delivery. Hence, several enhancement techniques have been developed to assist the delivery of these molecules across the skin [3]. Among these, iontophoresis, a technique that uses mild electric current for the transport enhancement, has been successfully employed to transdermally introduce peptide drugs into systemic circulation [4].…”

Section: Introductionmentioning

confidence: 99%

Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber

Malinovskaja

Laaksonen

Hirvonen

2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…Microwaves use high intensity electromagnetic radiation of 0.3-300 GHz for certain period of time to exert its permeation effect through thermal or non-thermal interaction with skin [9]. Jet injector uses high velocities for bombarding the skin and abrading to create superficial micro-pathways in the skin for delivery of powder and liquid formulations [10,11]. Most of the products using above-mentioned technologies are not currently available for purchase and have been withdrawn from the market by their developers or sellers.…”

Section: Introduction: Transdermal Route and Protein Deliverymentioning

confidence: 99%

Passive delivery of protein drugs through transdermal route

Chaulagain

Jain

Tiwari

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Skin is the largest external organ in the human body but its use for therapeutic purposes has been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and optimum polarity are fortunate enough to be used on skin therapeutics. But, at a time where modern therapeutics is slowly shifting from use of small molecular drugs towards the use of macromolecular therapeutic agents such as peptides, proteins and nucleotides in origin, skin therapeutics need to be evolved accordingly to cater the delivery of these agents. Physical technologies like iontophoresis, laser ablation, micro-needles and ultrasound, etc. have been introduced to enhance skin permeability. But their success is limited due to their complex working mechanisms and involvement of certain irreversible skin damage in some or other way. This review therefore explores the delivery strategies for transport of mainly peptide and protein drugs that do not involve any injuries (non-invasive) to the skin termed as passive delivery techniques. Chemical enhancers, nanocarriers, certain biological peptides and miscellaneous approaches like prodrugs are also thoroughly reviewed for their applications in protein delivery.

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Transdermal Delivery of Peptides and Proteins

Cited by 11 publications

References 47 publications

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber

Passive delivery of protein drugs through transdermal route

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