Transdermal delivery of heparin using low-frequency sonophoresis in combination with sponge spicules for venous thrombosis treatment

Zhai, Haojie; Zhang, Chi; Ou, Huilong; Chen, Ming

doi:10.1039/d1bm00703c

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…Zhu et al used a new combined system of low-frequency sonophoresis with an ultrasonic transducer and motor for calcein delivery, showing that a change of ultrasonic motor with static pressure can effectively control noninvasive permeability by adjusting motor driving amplitude voltage and duty ratio [ 70 ]. A study performed by Zhai and team used low-frequency sonophoresis for transdermal delivery of heparin with sponge spicules for the treatment of venous thrombosis, which confirmed that utilization of this combined technique significantly increases the transdermal delivery and is helpful for transdermal delivery of other hydrophilic macromolecules [ 71 ].…”

Section: Pharmaceutical and Biomedical Applications Of Sonophoresismentioning

confidence: 88%

Low‐Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery

Marathe,

Bhuvanashree,

Mehta

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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Sonophoresis is the most approachable mode of transdermal drug delivery system, wherein low‐frequency sonophoresis penetrates the drug molecules into the skin. It is an alternative method for an oral system of drug delivery and hypodermal injections. The cavitation effect is thought to be the main mechanism used in sonophoresis. The cavitation process involves forming a gaseous bubble and its rupture, induced in the coupled medium. Other mechanisms used are thermal effects, convectional effects, and mechanical effects. It mainly applies to transporting hydrophilic drugs, macromolecules, gene delivery, and vaccine delivery. It is also used in carrier‐mediated delivery in the form of micelles, liposomes, and dendrimers. Some synergistic effects of sonophoresis, along with some permeation enhancers, such as chemical enhancers, iontophoresis, electroporation, and microneedles, increased the effectiveness of drug penetration. Sonophoresis‐mediated ocular drug delivery, nail drug delivery, gene delivery to the brain, sports medicine, and sonothrombolysis are also widely used. In conclusion, while sonophoresis offers promising applications in diverse fields, further research is essential to comprehensively elucidate the biophysical mechanisms governing ultrasound‐tissue interactions. Addressing these gaps in understanding will enable the refinement and optimization of sonophoresis‐based therapeutic strategies for enhanced clinical efficacy.

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Section: Pharmaceutical and Biomedical Applications Of Sonophoresismentioning

confidence: 88%

Low‐Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery

Marathe,

Bhuvanashree,

Mehta

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

Large-scale mariculture of the sponge Haliclona simulans on floating rafts in Zhao'an Bay, Fujian Province, China

Xia²,

Ou³

et al. 2023

Aquaculture

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Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

Liu

Wang

et al. 2022

International Journal of Pharmaceutics

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Transdermal delivery of heparin using low-frequency sonophoresis in combination with sponge spicules for venous thrombosis treatment

Abstract: This study reports the use of low-frequency sonophoresis (LFS) in combination with sponge Haliclona sp. spicules (SHS), referred to as cSoSp (combined Sonophoresis and Spicules), can enhance the transdermal drug...

Cited by 6 publications

References 42 publications

Low‐Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery

Low‐Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery

Large-scale mariculture of the sponge Haliclona simulans on floating rafts in Zhao'an Bay, Fujian Province, China

Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

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