Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

Liu, Yiwen; Wu, Yujing; Wang, Wenxi; Yang, Qingliang; Yang, Gensheng

doi:10.1016/j.ijpharm.2022.121811

Cited by 46 publications

(21 citation statements)

References 183 publications

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“…However, eutectogels also benefit from several features that can be exploited in controlled drug delivery systems, such as good biocompatibility, adhesiveness, stiffness matching biological tissues, and non-volatile nature [ 8 ]. Furthermore, DES have proved to dramatically increase the solubility, stability, and permeability of drugs, becoming versatile delivery systems for nasal, transdermal, and oral administration with improved bioavailability [ [9] , [10] , [11] ].…”

Section: Introductionmentioning

confidence: 99%

Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

Bianchi

Zhang

Catlin

et al. 2022

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

Bianchi

Zhang

Catlin

et al. 2022

Materials Today Bio

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“…NADES experience many beneficial properties which include low volatility, sustainability and biodegradability, low cost and simplicity of preparation, as well as the potential of fine-tuning for specific applications [ 53 , 54 , 55 , 56 ]. These beneficial properties make NADES useful in a variety of applications, including the pharmaceutical industry [ 57 , 58 , 59 , 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Jeliński¹,

Cysewski²

2022

IJMS

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Solubility of active pharmaceutical ingredients is an important aspect of drug processing and formulation. Although caffeine was a subject of many studies aiming to quantify saturated solutions, many applied solvents suffer from not being environmentally friendly. This work fills this gap by presenting the results of solubility measurements in choline chloride natural deep eutectic solvents, ccNADES, comprising one of seven of the following polyalcohols: glycerol, sorbitol, xylitol, glucose, sucrose, maltose and fructose. The ratio of ccNADES components was optimized for maximizing caffeine solubility at room temperature. Additionally, temperature dependent solubility was measured for the first four systems exhibiting the highest solubility potential, both in their neat forms and in mixtures with water. Results were used for intermolecular interactions assessments using the COSMO-RS-DARE approach, which led to a perfect match between experimental and computed solubility values. An important methodological discussion was provided for an appropriate definition of the systems. Surprising linear trends were observed between the values of fitting parameters and water-ccNADES composition. In addition, comments on selection of the values of the fusion thermodynamic parameters were provided, which led to the conclusion that COSMO-RS-DARE solubility computations can effectively compensate for the inaccuracies of these important physicochemical properties.

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“…Deep eutectic solvents (DESs), known as ionic liquid (IL) analogues, are innovative generations or a new class of substitutions for ILs and other traditional solvents, which were first discovered to define a mixture of choline chloride (ChCl) and urea with a liquid state at room temperature. , DES can be fabricated by synergistically combining a hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD) in an optimal molar ratio, which results in a lower melting point compared to their individual components due to the formation of the hydrogen bond network structures between HBA and HBD . DES exhibits many excellent properties, such as high chemical and thermal stability, negligible volatility, adjustable polarity, cost-effectiveness, nontoxicity, good biodegradability, biocompatibility, etc., making DES a green and promising alternative in various applications, including nanomaterial synthesis, metal processing, electrochemistry, catalysis, biology, and energy. − Like ILs, DESs have also been found to exhibit excellent tribological properties as lubricants or lubricating additives. , For example, ChCl-based DESs were used as lubricants on steel surfaces, exhibiting lower friction compared to engine oil . To date, DESs fabricated by different HBAs and HBDs have shown superior tribological properties in various application scenarios. − Generally, the excellent tribological performance of DES lubricants is often ascribed to the formed lubricating films on the contact surface. , Unfortunately, the lubricating film formed by DES with low viscosity is easily destroyed, leading to lubrication instability, severe wear, and even failure phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Green Sorbitol-Based Deep Eutectic Solvents Enabling Near Zero-Wear of Steel–Steel Tribopairs

Gao,

Liu,

Wang

et al. 2023

ACS Sustainable Chem. Eng.

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Deep eutectic solvents have emerged as promising alternatives to traditional lubricants due to their ease of preparation, low cost, low/no pollution, reproducibility, and unique antifriction and antiwear performance. Herein, green sorbitol-based deep eutectic solvents are successfully synthesized using d-sorbitol and quaternary ammonium salts as hydrogen bond donors and acceptors, respectively, through a simple heating and stirring method. The synthesized sorbitol-based deep eutectic solvents exhibit good thermostability, high viscosity, and favorable wettability on the steel surface. Notably, tribological tests demonstrated that the sorbitol-based deep eutectic solvents displayed outstanding antiwear and friction-reducing properties and were observed to achieve nearly wearless behavior on the steel surface under high contact pressure (2.16 GPa). X-ray photoelectron spectroscopy, scanning electron microscopy, and high-resolution transmission electron microscopy revealed that complex tribofilms were formed because of the tribochemical reactions and physical adsorption of deep eutectic solvents on steel substrates, resulting in outstanding tribological properties. These results demonstrate that the as-synthesized sorbitol-based deep eutectic solvents are promising candidates for green and sustainable lubricating materials with eminent tribological properties. Furthermore, the present work may provide guidance and reference for the development of green and high-performance deep eutectic solvent-based lubricating materials.

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Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

Cited by 46 publications

References 183 publications

Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Green Sorbitol-Based Deep Eutectic Solvents Enabling Near Zero-Wear of Steel–Steel Tribopairs

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