Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions

Piemi, Martin Pierre Youenang; Luca, Martha de; Grossiord, J. L.; Seiller, M.; Marty, Jean‐Paul

doi:10.1016/s0378-5173(98)00189-6

Cited by 16 publications

(1 citation statement)

References 8 publications

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“…For glucose and lactic acid, which are examples of water‐soluble compounds, it was found that the skin uptake of both compounds as well as the flux of glucose across skin was in the following order: o/w > w/o/w > w/o [62, 84]. The dosing condition did not change the effect of the type of emulsion on the transdermal delivery of glucose as the rank order of the emulsions was the same for unoccluded finite dose and occluded infinite dose [85]. The higher skin uptake as well as flux from the o/w emulsion compared with the w/o/w emulsion was explained by a higher concentration of glucose and lactic acid in the external phase of the o/w emulsion.…”

Section: Dermal and Transdermal Delivery From Emulsionsmentioning

confidence: 99%

Formulation effects of topical emulsions on transdermal and dermal delivery

Otto

Plessis

Wiechers³

2009

Intern J of Cosmetic Sci

182

109

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SynopsisIt has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be enhanced, e.g. by an increase in thermodynamic activity, supersaturation and penetration modifiers. Furthermore, dermal and transdermal delivery can be influenced by the interactions that may occur between the vehicle and the skin on the one hand, and interactions between the active ingredient and the skin on the other hand. Emulsions are widely used as cosmetic and pharmaceutical formulations because of their excellent solubilizing capacities for lipophilic and hydrophilic active ingredients and application acceptability. This review focuses, in particular, on the effect of emulsions on the dermal and transdermal delivery of active ingredients. It is shown that the type of emulsion (w/o vs. o/w emulsion), the droplet size, the emollient, the emulsifier as well as the surfactant organization (micelles, lyotropic liquid crystals) in the emulsion may affect the cutaneous and percutaneous absorption. Examples substantiate the fact that emulsion constituents such as emollients and emulsifiers should be selected carefully for optimal efficiency of the formulation. Moreover, to understand the influence of emulsion on dermal and transdermal delivery, the physicochemical properties of the formulation after application are considered. Ré suméOn sait que le véhicule dans lequel un perméat est appliqué sur la peau a un effet spécifique sur la libération dermique et transdermique des ingrédients actifs. Les absorptions cutanées et percutanées peuvent être augmentées, par exemple par une augmentation de l'activité thermodynamique, une super saturation ou la présence de modificateurs de pénétration. Ainsi, la libération dermique et transdermique peut être influencée par les interactions susceptibles de s'établir d'un côté entre le véhicule et la peau et de l'autre entre l'ingrédient actif et la peau. Les émulsions sont largement utilisées dans les formulations cosmétiques et pharmaceutiques du fait de leurs excellentes capacités de solubilisation des ingrédients actifs lipophiles et hydrophiles, et du fait de leur bonne tolérance. Cette revue traite, en particulier, des effets des émulsions sur la libération dermique et trans-dermique d'ingrédients actifs. On montre que le type d'émulsion (E/H par rapport à H/E), la granulomé-trie, l'émollient, les émulsifiants, autant que l'organisation des tensioactifs (micelles, cristaux liquides lyotropes) peuvent influencer l'absorption cutanée et percutanée. Des exemples justifient le fait qu'un choix soigné des constituants de l'émulsion comme les émollients et les émulsifiants peut optimiser l'efficacité de la formulation. En complément, pour comprendre l'influence de l'émulsion sur la libéra-tion dermique et transdermique, les propriétés physico-chimiques de la formulation après application sont étudiées.The effect of the vehicle on dermal and transdermal deli...

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Section: Dermal and Transdermal Delivery From Emulsionsmentioning

confidence: 99%

Formulation effects of topical emulsions on transdermal and dermal delivery

Otto

Plessis

Wiechers³

2009

Intern J of Cosmetic Sci

182

109

View full text Add to dashboard Cite

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Development and characterization of solid lipid microparticles containing vitamin C for topical and cosmetic use

et al. 2016

Euro J Lipid Sci & Tech

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Solid lipid microparticles (SLMs), combined with the advantages of double emulsions (W/O/W) and water-in-oil micro emulsions, are developed for transdermal administration. A modified one-step emulsification method was introduced, which made the industrial production of SLMs easier. Variables involved in preparation that may affect the solubility, stability, and entrapment efficiency of SLMs were investigated. With vitamin C as a model active, the advantages of SLMs in transdermal administration were studied further. Vitamin C, encapsulated by SLMs, exhibited an enhanced storage stability up to 1 month under 25°C and a sustained releasing profile over 24 h. Furthermore, the SLMs was very helpful in delivering vitamin C molecules into skin through stratum corneum. The result showed 5.52-fold (p < 0.05) increased absorption of vitamin C, compared to the vitamin C solution. These studies demonstrate that SLMs could be a promising method for facilitating transdermal penetration of active ingredients with high solubility and low permeability.Practical applications: SLMs could be used as a drug delivery system for hydrophilic active ingredients with low permeability. Experiments have shown better stability and skin permeability of vitamin C incorporated in SLMs when compared with pure vitamin C. Furthermore, the method of producing SLMs is simple and can be realized in a way of industrial production. Since SLMs can dissolve in water, SLMs can be directly used on wet skin with excellent skin-touch feel. As a result, SLMs could be a practical delivery system for hydrophilic compounds with low permeability in many applications such as pharmaceuticals and cosmetics.

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The Effects of Emulsifiers and Emulsion Formulation Types on Dermal and Transdermal Drug Delivery

Otto

Plessis

2015

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

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Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions

Cited by 16 publications

References 8 publications

Formulation effects of topical emulsions on transdermal and dermal delivery

Formulation effects of topical emulsions on transdermal and dermal delivery

Development and characterization of solid lipid microparticles containing vitamin C for topical and cosmetic use

The Effects of Emulsifiers and Emulsion Formulation Types on Dermal and Transdermal Drug Delivery

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