Transdermal delivery from liposomal formulations – Evolution of the technology over the last three decades

Ashtikar, Mukul; Nagarsekar, Kalpa; Fahr, Alfred

doi:10.1016/j.jconrel.2016.09.008

Cited by 124 publications

(63 citation statements)

References 111 publications

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“…A visible increase in the hair number is observed after 6 months of treatment them into liposomes made of phospholipids, a well-known technique to achieve transdermal delivery in topical applications (Ashtikar et al, 2016;Franzé et al, 2017;Irby et al, 2017). Delivery of the lotion components is ensured by embedding FIGURE 1 A representative subject of the male (upper part) and female (lower part) group at baseline (a, c) and 6 months (b, d).…”

Section: Discussionmentioning

confidence: 99%

“…DGLA is a 20-carbon ω-6 polyunsaturated fatty acid deriving, in humans, from linolenic acid. Liposomes have been extensively used as effective carriers for transdermal delivery of different medications, and liposomes made of phospholipids, like those of the two formulations of interest, have been shown to be effective especially for topical applications (Ashtikar, Nagarsekar, & Fahr, 2016: Franzé et al, 2017Irby, Du, & Li, 2017). PGE1 has been long used in the treatment of peripheral vascular disorders (Murota, Kotobuki, Umegaki, Tani, & Katayama, 2008) as a result of its effects, including vasodilation, inhibition of leukocyte adhesion, inhibition of platelet aggregation, and suppression of inflammation (Kerins, Murray, & FitzGerald, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…Propionyl-L-carnitine is a naturally occurring derivative of carnitine that protects tissues from oxidative damage as a result of its antioxidant properties (Mingorance, Rodriguez-Rodriguez, Justo, Herrera, & de Sotomayor, 2011) and favors carbohydrate and lipid metabolism, increasing adenosine triphosphate generation, thus stimulating energy production (Wiseman & Brogden, 1998). Liposomes have been extensively used as effective carriers for transdermal delivery of different medications, and liposomes made of phospholipids, like those of the two formulations of interest, have been shown to be effective especially for topical applications (Ashtikar, Nagarsekar, & Fahr, 2016: Franzé et al, 2017Irby, Du, & Li, 2017). The aim of the present investigation was to assess the safety and efficacy of these new cosmetic formulations through a prospective clinical study on both men and women suffering from pattern hair loss.…”

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confidence: 99%

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A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l -carnitine to prevent and treat hair loss: A prospective investigation

Brotzu¹,

Fadda

Manca

et al. 2018

Dermatologic Therapy

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Hair loss is a common aesthetic disorder that can be triggered by genetic, inflammatory, hormonal, and environmental factors acting on hair follicles and their life cycle. There are several types of hair loss that differ in causes, symptoms, and spatial and temporal progression. Androgenic alopecia, a common form of hair loss, is the consequence of a decreased microcirculation of the scalp as well as the toxic action of elevated dihydrotestosterone levels on the hair bulbs.In the present study, the lotions TRINOV Lozione Anticaduta Uomo and TRINOV Lozione Anticaduta Donna, containing dihomo-γ-linolenic acid (DGLA), S-equol, and propionyl-L-carnitine, were tested on 30 men and 30 women (mean age of men was 46.6 AE 6.4 years; mean age of women was 49.5 AE 9.0) with signs of androgenic alopecia, respectively. DGLA is a precursor of the prostaglandin PGE1, which acts by improving microcirculation; S-equol inhibits 5α-reductases, thus preventing the transformation of testosterone into dihydrotestosterone; and propionyl-L-carnitine promotes lipid metabolism, stimulating energy production. These three molecules are loaded into liposomes for their effective transdermal delivery. Daily topical applications of the lotions resulted in a hair count that significantly increased for women and marginally increased for men after 6 months of treatment. Furthermore, significant increase in anagen hair and a significant decrease in telogen hair were observed starting from 3 months in male and 1 month in female patients. Thus, the formulations under investigation were effective in attenuating androgenic alopecia-related hair loss in men and women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l -carnitine to prevent and treat hair loss: A prospective investigation

Brotzu¹,

Fadda

Manca

et al. 2018

Dermatologic Therapy

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“…Polymer-based nanocarriers include dendrimers, micelles, nanospheres/ lipospheres, and nanocapsules (Ashtikar, Nagarsekar, & Fahr, 2016;Dragicevic-Curic, Scheglmann, Albrecht, & Fahr, 2009;Hung et al, 2015;Kim et al, 2010;Nasr, Abdel-Hamid, & Alyoussef, 2015).…”

Section: Polymer-based Nanocarriersmentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

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Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale (“skin nanobiology”), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies (“nanodiagnosis”), and (c) treatment through innovative therapeutic agents, including phototherapy (“photonanotherapy”/“photonanodermatology”) and systemic/topical drug administration (“nanotherapy”) at the nanoscale, and drug delivery—such as transdermal or dermal drug delivery (TDDD/DDD)—enhanced and improved by nanostructures and nanodrugs (“nanodrug delivery”). Nanodermatology, as a super‐specialized branch of dermatology, is a quite recent specialty: the “Nanodermatology Society” founded by the eminent dermatologist Dr. Adnan Nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy‐makers and regulators, as well as students and medical residents. Psoriasis has a prevalence of 2–3% worldwide and imposes a severe clinical and societal burden. Nanodermatology‐based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health‐care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

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“…The advantages of the percutaneous route include painlessness, avoidance of first pass metabolism and the absence of erratic absorption, control over the rate of drug release, easy termination of therapy, and the possibility of self-administration and sustained drug release with a single application [2,3,4]. Despite the obvious advantages of this route of drug administration, only about 20 active pharmaceutical ingredients are used in clinical practice in the form of transdermal patches [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

et al. 2016

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The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an Agilent 1200 Series HPLC system coupled to an Agilent G1969A TOF-MS system. Transdermal flux values of the drugs were determined from the steady-state portion of the cumulative amount versus time curves. Following twelve hours of microneedle roller application, there was a 6.74-fold increase in the percutaneous penetration of tiagabine hydrochloride (86.42 ± 25.66 µg/cm2/h) compared to passive delivery (12.83 ± 6.30 µg/cm2/h). For carbamazepine in 20% ethanol, passive transdermal flux of 7.85 ± 0.60 µg/cm2/h was observed compared to 10.85 ± 0.11 µg/cm2/h after microneedle treatment. Carbamazepine reconstituted in 30% ethanol resulted in only a 1.19-fold increase in drug permeation across porcine skin (36.73 ± 1.83 µg/cm2/h versus 30.74 ± 1.32 µg/cm2/h). Differences in flux values of untreated and microneedle-treated porcine skin using solid microneedles for the transdermal delivery of tiagabine were statistically significant. Although there were 1.38- and 1.19-fold increases in transdermal flux values of carbamazepine when applied as 20% and 30% ethanol solutions across microneedle-treated porcine skin, respectively, the increases were not statistically significant.

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Transdermal delivery from liposomal formulations – Evolution of the technology over the last three decades

Cited by 124 publications

References 111 publications

A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l -carnitine to prevent and treat hair loss: A prospective investigation

A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l -carnitine to prevent and treat hair loss: A prospective investigation

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

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