Transcytosis of Nanomedicine for Tumor Penetration

Liu, Yan; Huo, Yingying; Yao, Lin; Xu, Yuhong; Meng, Fanqiang; Li, Haifeng; Sun, Kang; Zhou, Guangdong; Kohane, Daniel S.; Tao, Ke

doi:10.1021/acs.nanolett.9b03211

Cited by 88 publications

(63 citation statements)

References 77 publications

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“… 84 More uplifting news is that transcytosis of nanomedicine with a positive charge and certain ligand modification has been shown to mediate the active intra-tumor penetration without the need to overcome the hindrance of ECM. 92 Transcellular transport occurs in any nanoparticles modified with peptides containing C-terminal arginine that bind to neuropilin-1 or neuropilin-2 on the tumor plasma membrane. 84 This is very exciting news for scientists to design a highly effective tumor-permeable gene delivery system, because it allows nanomedicines to target the vascular endothelial cells and trigger adsorption or receptor-mediated endocytosis for exocytosis to the adjacent cell on the other side without size limitation.…”

Section: Main Textmentioning

confidence: 99%

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Liu

Zhang

Zhu

et al. 2020

Molecular Therapy - Methods & Clinical Development

130

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Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors for decades with the advantages of excellent biodegradability, biocompatibility, and high nucleic acid encapsulation efficiency. However, the clinical use of CLs in cancer gene therapy is limited because of many uncertain factors in vivo . Extracellular barriers such as opsonization, rapid clearance by the reticuloendothelial system and poor tumor penetration, and intracellular barriers, including endosomal/lysosomal entrapped network and restricted diffusion to the nucleus, make CLs not the ideal vector for transferring extrinsic genes in the body. However, the obstacles in achieving productive therapeutic effects of nucleic acids can be addressed by tailoring the properties of CLs, which are influenced by lipid compositions and surface modification. This review focuses on the physiological barriers of CLs against cancer gene therapy and the effects of lipid compositions on governing transfection efficiency, and it briefly discusses the impacts of particle size, membrane charge density, and surface modification on the fate of CLs in vivo , which may provide guidance for their preclinical studies.

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Section: Main Textmentioning

confidence: 99%

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Liu

Zhang

Zhu

et al. 2020

Molecular Therapy - Methods & Clinical Development

130

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“…Although nanomedicines have brought great hope to tumor treatments in recent years, the ine cient penetration into tumor severely limits their application. Previous studies focused on size-shrinking of drugs [43][44][45] , remodeling of tumor microenvironment 46 , and transcytosis [47][48][49] to enhance the tumor penetration. However, none of these strategies overcome the key hinder of drug delivery: TIP, especially TIFP.…”

Section: Discussionmentioning

confidence: 99%

Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Cong

et al. 2021

ACS Nano

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Owing to de ciency of lymphatic re ux in the tumor, the retention of tumor interstitial uid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based "Nano-lymphatic" to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial uid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration.Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the "Nano-lymphatic" relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence.Our nding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great signi cance for drug delivery.

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“…Particularly, recent studies showed that nanomedicines without special features (e.g., charge and ligands) could enter into a tumor through transcytosis. As noted in several reports, transcytosis-capable nanomedicines hold emerging potential to facilitate deep penetration via consecutive transcytosis processes [81][82][83].…”

Section: Transcytosable Nanomedicinementioning

confidence: 94%

Insights into Multifunctional Nanoparticle-Based Drug Delivery Systems for Glioblastoma Treatment

et al. 2021

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Glioblastoma (GB) is an aggressive cancer with high microvascular proliferation, resulting in accelerated invasion and diffused infiltration into the surrounding brain tissues with very low survival rates. Treatment options are often multimodal, such as surgical resection with concurrent radiotherapy and chemotherapy. The development of resistance of tumor cells to radiation in the areas of hypoxia decreases the efficiency of such treatments. Additionally, the difficulty of ensuring drugs effectively cross the natural blood–brain barrier (BBB) substantially reduces treatment efficiency. These conditions concomitantly limit the efficacy of standard chemotherapeutic agents available for GB. Indeed, there is an urgent need of a multifunctional drug vehicle system that has potential to transport anticancer drugs efficiently to the target and can successfully cross the BBB. In this review, we summarize some nanoparticle (NP)-based therapeutics attached to GB cells with antigens and membrane receptors for site-directed drug targeting. Such multicore drug delivery systems are potentially biodegradable, site-directed, nontoxic to normal cells and offer long-lasting therapeutic effects against brain cancer. These models could have better therapeutic potential for GB as well as efficient drug delivery reaching the tumor milieu. The goal of this article is to provide key considerations and a better understanding of the development of nanotherapeutics with good targetability and better tolerability in the fight against GB.

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Transcytosis of Nanomedicine for Tumor Penetration

Cited by 88 publications

References 77 publications

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Insights into Multifunctional Nanoparticle-Based Drug Delivery Systems for Glioblastoma Treatment

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