Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Abstract

Owing to de ciency of lymphatic re ux in the tumor, the retention of tumor interstitial uid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based "Nano-lymphatic" to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial uid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration.Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the "Nano-lymphatic" relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence.Our nding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great signi cance for drug delivery.

Nanotechnology-based combinatorial phototherapy for enhanced cancer treatment

“…For instance, we invented pyroelectric catalysis-based “nano-lymphatic” to decompose the tumor interstitial fluid, and reduce TIFP via pyroelectric catalysis-based water splitting, resulting in a smart combination of tumor-penetrating therapeutic strategy and photothermal therapy. 140 Living photosynthetic bacteria (PSB) have been utilized as hypoxia-targeted carriers and PTAs for tumor therapy with hypoxia-targeting properties due to their near-infrared chemotaxis and physiological characteristics as facultative aerobes. 141 Antibody-directed phototherapy (ADP) 142 has been developed by conjugating a phototherapeutic agent to an antibody like ADCs (antibody–drug conjugates) do.…”

Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets

“…Very recently, pyroelectric materials with thermal-electricity conversion ability have been found with high sensitivity to temperature variations as small as 6 Â 10 À6 C. 10 When temperature varies, an internal pyroelectric eld is formed, which drives the electron-hole separation for redox reactions with surrounding substrates. 6,[11][12][13][14][15] For example, black phosphorus (BP) nanosheets with pyroelectricity have been employed for pyro-catalytic dye decomposition and hydrogen generation under thermal cycling (15-65 C). 16 Intriguingly, pyroelectric materials can also be activated under cold treatment, thereby allowing them to act as cold catalysts.…”

Engineering Electronic Band Structure of Binary Thermoelectric Nanocatalysts for Augmented Pyrocatalytic Tumor Nanotherapy

“…During the heating and cooling processes, pyroelectric materials promote the conversion of temperature variations into pyroelectric charges, which can further react with the surrounding oxygen (O 2 ) molecules to produce toxic ROS to deplete HSPs and reduce the endurance of tumor cells to the hyperthermia effect. [ 8,9 ] Specifically, thermoelectrics, as a subset of the semiconductor industry, principally depend on canonical binary compounds, such as Bi 2 Te 3 , [ 10 ] SnSe, [ 11 ] and PbTe. [ 12 ] Earth‐abundant and low‐toxicity sulfur‐based counterparts have attracted increasing attention as potential alternative thermoelectric materials for biomedical applications.…”

“…[12] Earth-abundant and low-toxicity sulfur-based counterparts have attracted increasing attention as potential alternative thermoelectric materials for biomedical applications. [9,13] However, the pyroelectric performance of sulfur-based binary compounds is impaired by ionic bonding and their low atomic weights. [14] It has been proven that the reconstruction of binary compounds by inserting a third agent can substantially modify the electronic and phonon structures of thermoelectric materials, thus resulting in augmented thermoelectric performance.…”