Transcutaneous RF-Powered Implantable Minipump Driven by a Class-E Transmitter

Moore, William; Holschneider, Daniel P.; Givrad, Tina K.; Maarek, Jean-Michel I.

doi:10.1109/tbme.2006.873698

Cited by 24 publications

(24 citation statements)

References 10 publications

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“…Wireless operation by inductive power transfer was successfully demonstrated using a custom apparatus developed for biomedical implants (2MHz) [8]. Flow rates up to 2 μL/min (I rms = 0.24 mA) with hand-wound Litz wire coils and 3.4 μL/min (I rms = 0.78 mA) with coils printed on PCBs were achieved.…”

Section: Wireless Operationmentioning

confidence: 99%

A parylene bellows electrochemical actuator for intraocular drug delivery

Sheybani

Kuo

et al. 2009

TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference

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The first electrochemical actuator with a Parylene bellows for intraocular drug delivery is presented in which the bellows separates the electrolysis actuation chamber from the drug reservoir. The Parylene bellows was fabricated using a novel polyethylene glycol (PEG)-molding process and mechanically characterized. Optimization of the gas generation efficiency of the actuators was performed. We achieved an efficiency approaching 80% and over 1.5 mm deflection with our actuator. Wireless operation was also demonstrated.

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Section: Wireless Operationmentioning

confidence: 99%

A parylene bellows electrochemical actuator for intraocular drug delivery

Sheybani

Kuo

et al. 2009

TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference

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“…Details of the design and fabrication of the first and second generation of the MIP have been published (27,33). The MIP consists of an intravenous catheter, a silicone embedded electronics controller remotely activated by a photodetector that responds to trains of light pulses (30 KHz frequency) and controls a normally-closed miniaturized solenoid valve, an ejection chamber containing the radiotracer, and a silastic reservoir containing a euthanasia solution.…”

Section: Microbolus Infusion Pumpmentioning

confidence: 99%

“…To facilitate brain mapping during locomotor activity, our laboratory has developed a selfcontained, fully implantable miniature infusion pump (MIP) that in small animals (27,28) allows bolus injection of pharmacologic agents by remote activation. The ability to trigger this pump by remote activation has allowed us to rapidly inject cerebral blood flow tracers in the nonrestrained, nontethered animal, thereby allowing the brain mapping of behaviors involving locomotion.…”

Section: Introductionmentioning

confidence: 99%

Brain maps on the go: Functional imaging during motor challenge in animals

Holschneider

Maarek

2008

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Brain mapping in the freely-moving animal is useful for studying motor circuits, not only because it avoids the potential confound of sedation or restraints, but because activated brain states may serve to accentuate differences that only manifest partially while a subject is in the resting state. Perfusion or metabolic mapping using autoradiography allows one to examine changes in brain function at the circuit level across the entire brain with a spatial resolution (∼100 microns) appropriate for the rat or mouse brain, and a temporal resolution (seconds -minutes) sufficient for capturing acute brain changes. Here we summarize the application of these methods to the functional brain mapping of behaviors involving locomotion of small animals, methods for the three dimensional reconstruction of the brain from autoradiographic sections, voxel based analysis of the whole brain, and generation of maps of the flattened rat cortex. Application of these methods in animal models promises utility in improving our understanding of motor function in the normal brain, and of the effects of neuropathology and treatment interventions such as exercise have on the reorganization of motor circuits.

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“…The class-E PA is the commonly used PA due to its advantages in size, cost and efficiency [18]- [21]. However, its characteristics are easily affected by the design parameters' variations [22], [23].…”

Section: Introductionmentioning

confidence: 99%

Modeling and Optimization of Class-E Amplifier at Subnominal Condition in a Wireless Power Transfer System for Biomedical Implants

Líu

Shao

Fang

2017

IEEE Trans. Biomed. Circuits Syst.

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Abstract-For the class-E amplifier in a wireless power transfer (WPT) system, the design parameters are always determined by the nominal model. However, this model neglects the conduction loss and voltage stress of MOSFET and cannot guarantee the highest efficiency in the WPT system for biomedical implants. To solve this problem, this paper proposes a novel circuit model of the subnominal class-E amplifier. On a WPT platform for capsule endoscope, the proposed model was validated to be effective and the relationship between the amplifier's design parameters and its characteristics was analyzed. At a given duty ratio, the design parameters with the highest efficiency and safe voltage stress are derived and the condition is called 'optimal subnominal condition.' The amplifier's efficiency can reach the highest of 99.3% at the 0.097 duty ratio. Furthermore, at the 0.5 duty ratio, the measured efficiency of the optimal subnominal condition can reach 90.8%, which is 15.2% higher than that of the nominal condition. Then, a WPT experiment with a receiving unit was carried out to validate the feasibility of the optimized amplifier. In general, the design parameters of class-E amplifier in a WPT system for biomedical implants can be determined with the proposed optimization method in this paper.Index Terms-Biomedical implants, class-E amplifier, efficiency improvement, subnominal condition, wireless power transfer system, zero-voltage-switching (ZVS).

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Transcutaneous RF-Powered Implantable Minipump Driven by a Class-E Transmitter

Cited by 24 publications

References 10 publications

A parylene bellows electrochemical actuator for intraocular drug delivery

A parylene bellows electrochemical actuator for intraocular drug delivery

Brain maps on the go: Functional imaging during motor challenge in animals

Modeling and Optimization of Class-E Amplifier at Subnominal Condition in a Wireless Power Transfer System for Biomedical Implants

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