A parylene bellows electrochemical actuator for intraocular drug delivery

Li, P.-Y.; Sheybani, Roya; Kuo, Jen-Tsai; Meng, Ellis

doi:10.1109/sensor.2009.5285819

Cited by 13 publications

(16 citation statements)

References 6 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously reported Pt electrodes deposited on glass substrates [3,5] were robust up to currents greater than 5 mA (data not shown). Pt electrodes on Parylene, however, exhibit delamination even for modest applied currents.…”

Section: Electrolysis Electrodesmentioning

confidence: 75%

“…The operation principle and refill method are summarized in Figure 2. A bellows actuator format [3] was adopted to separate the drug from the electrolyzed fluid and prevent associated drug degradation, an undesirable effect reported in our previous work [4]. The electrochemically-actuated bellows imposes a pneumatic driving force on drug contained in the adjacent reservoir, forcing it out through the delivery cannula.…”

Section: Designmentioning

confidence: 99%

“…The electrolysis actuator consists of a pair of interdigitated electrodes, electrolyte (in this case, deionized (DI) water), 978-1-4244-5763-2/10/$26.00 ©2010 IEEEand a flexible pressure transmitting membrane. A flexible bellows was chosen over corrugated membranes and flat membranes; higher deflections were achieved with bellows while imposing lower material stress under pressure loading [3,5]. …”

Section: Designmentioning

confidence: 99%

“…Pt (2000 Å) and Pt/Ti (2000 Å/500 Å) electrodes were patterned using a standard liftoff process described in [3,5]. Following removal from the supporting Si substrate, electrodes were mounted on a flexible polyetheretherketone (PEEK) substrate ( Figure 3).…”

Section: Fabrication and Assembly Electrolysis Actuator Fabrication Amentioning

confidence: 99%

“…Following removal from the supporting Si substrate, electrodes were mounted on a flexible polyetheretherketone (PEEK) substrate ( Figure 3). Parylene bellows were fabricated using a polyethylene glycol (PEG) molding process described previously [3,5]. Briefly, a silicone rubber master mold was used to cast PEG bellows forms.…”

Section: Fabrication and Assembly Electrolysis Actuator Fabrication Amentioning

confidence: 99%

See 4 more Smart Citations

Implantable MEMS drug delivery device for cancer radiation reduction

Gensler

Sheybani

et al. 2010

2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS)

View full text Add to dashboard Cite

We present the first implantable MEMS drug delivery device that includes an electrochemical bellows pump, refillable drug reservoir, and dual regulation valve. Multiple drug pump configurations were fabricated, assembled, and tested. Delivery of agents for cancer radiation reduction was demonstrated. In vivo chronic delivery of radiation sensitizing agents in the form of small interfering (siRNA)-gold nanorod complexes (nanoplexes) directly to tumors induced in mice was achieved. Radiation therapy in conjunction with active drug pumping by electrolysis actuation resulted in significant reduction of colon cancer tumor (HT29) size (~50%) over diffusion-based delivery and intravenous injections. To our knowledge, this is the first MEMS drug delivery pump suitable for safe, efficacious, and local delivery of short half-life siRNA in vivo.

show abstract

Section: Electrolysis Electrodesmentioning

confidence: 75%

Section: Designmentioning

confidence: 99%

Section: Designmentioning

confidence: 99%

Section: Fabrication and Assembly Electrolysis Actuator Fabrication Amentioning

confidence: 99%

Section: Fabrication and Assembly Electrolysis Actuator Fabrication Amentioning

confidence: 99%

See 3 more Smart Citations

Implantable MEMS drug delivery device for cancer radiation reduction

Gensler

Sheybani

et al. 2010

2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS)

View full text Add to dashboard Cite

show abstract

An Electrochemically Actuated MEMS Device for Individualized Drug Delivery: an In Vitro Study

Song

Tng

et al. 2013

Adv Healthcare Materials

View full text Add to dashboard Cite

Individualized disease treatment is a promising branch for future medicine. In this work, we introduce an implantable microelectromechanical system (MEMS) based drug delivery device for programmable drug delivery. An in vitro study on cancer cell treatment has been conducted to demonstrate a proof-of-concept that the engineered device is suitable for individualized disease treatment. This is the first study to demonstrate that MEMS drug delivery devices can influence the outcome of cancer drug treatment through the use of individualized disease treatment regimes, where the strategy for drug dosages is tailored according to different individuals. The presented device is electrochemically actuated through a diaphragm membrane and made of polydimethylsiloxane (PDMS) for biocompatibility using simple and cost-effective microfabrication techniques. Individualized disease treatment was investigated using the in vitro programmed delivery of a chemotherapy drug, doxorubicin, to pancreatic cancer cell cultures. Cultured cell colonies of two pancreatic cancer cell lines (Panc-1 and MiaPaCa-2) were treated with three programmed schedules and monitored for 7 days. The result shows that the colony growth has been successfully inhibited for both cell lines among all the three treatment schedules. Also, the different observations between the two cell lines under different schedules reveal that MiaPaCa-2 cells are more sensitive to the drug applied. These results demonstrate that further development on the device will provide a promising novel platform for individualized disease treatment in future medicine as well as for automatic in vitro assays in drug development industry.

show abstract

An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model

Liu

Song

Liu

et al. 2015

Biomed Microdevices

View full text Add to dashboard Cite

The use of MEMS implantable drug delivery pump device enables one to program the desired drug delivery profile in the device for individualized medicine treatment to patients. In this study, a MEMS drug delivery device is prepared and employed for in vivo applications. 12 devices are implanted subcutaneously into Kunming mice for evaluating their long term biocompatibility and drug-delivery efficiency in vivo. All the mice survived after device implantation surgery procedures. Histological analysis result reveals a normal wound healing progression within the tissues-to-device contact areas. Serum analysis shows that all measured factors are within normal ranges and do not indicate any adverse responses associated with the implanted device. Phenylephrine formulation is chosen and delivered to the abdominal cavity of the mice by using either the implanted MEMS device (experimental group) or the syringe injection method (control group). Both groups show that they are able to precisely control and manipulate the increment rate of blood pressure in the small animals. Our result strongly suggests that the developed refillable implantable MEMS devices will serve as a viable option for future individualized medicine applications such as glaucoma, HIV-dementia and diabetes therapy.

show abstract

A parylene bellows electrochemical actuator for intraocular drug delivery

Cited by 13 publications

References 6 publications

Implantable MEMS drug delivery device for cancer radiation reduction

Implantable MEMS drug delivery device for cancer radiation reduction

An Electrochemically Actuated MEMS Device for Individualized Drug Delivery: an In Vitro Study

An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model

Contact Info

Product

Resources

About