Transcutaneous electroacupuncture improves dyspeptic symptoms and increases high frequency heart rate variability in patients with functional dyspepsia

Liu, Shi; Peng, Songxu; Hou, Xiaohua; Ke, Ming; Chen, J D Z

doi:10.1111/j.1365-2982.2008.01164.x

Cited by 102 publications

(162 citation statements)

References 28 publications

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“…Few studies confirm the effectiveness of hypnotherapy, although their results suggest that hypnotherapy may be more effective than drug therapy for the treatment of FD [71]. One study showed the efficacy of transcutaneous electroacupuncture in the treatment of FD [72], but in another study the results of classical six-point manual acupuncture could not be differentiated from the placebo [73]. Neither transcutaneous electroacupuncture nor manual acupuncture is widely practiced in Japan, and no studies have been reported.…”

Section: Treatmentmentioning

confidence: 95%

Evidence-based clinical practice guidelines for functional dyspepsia

et al. 2015

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General interest in functional gastrointestinal disorders is increasing among Japanese doctors as well as patients. This increase can be attributed to a number of factors, including recent increased interest in quality of life and advances in our understanding of the pathophysiology of gastrointestinal disease. Japan recently became the world's first country to list ''functional dyspepsia'' as a disease name for national insurance billing purposes. However, recognition and understanding of functional dyspepsia (FD) remain poor, and no standard treatment strategy has yet been established. Accordingly, the Japanese Society of Gastroenterology (JSGE) developed an evidence-based clinical practice guideline for FD, consisting of five sections: concept, definition, and epidemiology; pathophysiology; diagnosis; treatment; and prognosis and complications. This article summarizes the Japanese guideline, with particular focus on the treatment section. Once a patient is diagnosed with FD, the doctor should carefully explain the pathophysiology and benign nature of this condition, establish a good doctor-patient relationship, and then provide advice for daily living (diet and lifestyle modifications, explanations, and reassurance). The proposed pharmacological treatment is divided into two steps: initial treatment including an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); second-line treatment including anxiolytics, antidepressants, and Japanese traditional medicine (weak recommendation). H. pylori eradication, strongly recommended with a high evidence level, is positioned separately from other treatment flows. Conditions that do not respond to these treatment regimens are regarded as refractory FD. Patients will be further examined for other organic disorders or will be referred to specialists using other approaches such as psychosomatic treatment.

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Section: Treatmentmentioning

confidence: 95%

Evidence-based clinical practice guidelines for functional dyspepsia

et al. 2015

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“…[35][36][37] EA at ST36 improved the percentage of normal gastric slow waves as well as the percentage of tachygastria in healthy volunteers. 38 Liu et al 21 reported that 2-week TEA at ST36 decreased dyspepsia symptoms and elevated vagal activity in patients with functional dyspepsia. Two-week daily TEA at ST36 improved GI symptoms and quality of life in systemic sclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…These parameters were previously shown to be effective in treating GI symptoms in patients with gastroparesis, scleroderma and functional dyspepsia. 7,8,12,[19][20][21][22] Measurements of electrogastrography and electroencephalography Recording and analysis of the electrogastrography. A noninvasive method similar to electrocardiography, called electrogastrography, was used in this study.…”

Section: Transcutaneous Electroacupuncturementioning

confidence: 99%

Central and Peripheral Effects of Transcutaneous Acupuncture Treatment for Nausea in Patients with Diabetic Gastroparesis

Sarosiek

Song

Sun

et al. 2017

J Neurogastroenterol Motil

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Background/AimsNausea, an unpleasant symptom of diabetic gastroparesis (DMGP), has been reported to be alleviated by needleless transcutaneous electrical acupuncture (TEA). Our study was designed to utilize electroencephalography (EEG) and electrogastrography (EGG) recordings to investigate the central and peripheral responses of TEA in the treatment of nausea in DMGP patients. MethodsEleven DMGP subjects underwent simultaneous EEG and EGG testing while grading the severity of nausea following 30-minute intervals of: (1) baseline, (2) visual stimulation (VS) to provoke more nausea, (3) active VS together with TEA, and (4) TEA alone, and a final 15-minute recording without any intervention. ResultsThe nausea score was increased to 5.9 ± 1.5 with VS (P < 0.05, vs 3.5 ± 1.0 at baseline), then reduced to 3.5 ± 1.2 with VS plus TEA, and to 2.5 ± 1.3 with TEA alone, while it continued at a score of 2.9 ± 1.0 post TEA (all significant, P < 0.05, vs VS without TEA). The mean percentage of normal gastric slow waves was decreased to 60.0 ± 5.7% with VS (P < 0.05, vs 66.6 ± 4.5% at baseline), then improved to 69.2 ± 4.8% with VS plus TEA, and maintained at 70 ± 3.6% with TEA alone. During initial VS, EEG signals showed right inferior frontal activity as the prominent finding, but during VS with TEA, left inferior frontal activity predominated. ConclusionsIn DMGP, TEA improves gastric dysrhythmia and ameliorates nausea. TEA treatment of nausea provoked by VS resulted in a change of dominance from right to left inferior frontal lobe activity. These data provide new understandings of peripheral and central mechanisms for nausea, and potential future directions for DMGP treatment approaches.

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“…Recent study showed that TENS applied to the acupuncture points (transcutaneous-EA; TEA) at the hands and lower legs improves GI symptoms in patients with FD [25] . Effects of acupuncture on GI motility is mediated via the CNS levels, not the spinal levels.…”

Section: Anti-stress Effects Of Somatosensory Stimulation 2-1 Effectmentioning

confidence: 99%

Anti-stress Effect of Hypothalamic Oxytocin, Importance of Somatosensory Stimulation and Social Buffering

Takahashi

Babygirija

Ludwig

2015

International Journal of Neurology Research

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A growing body of evidence suggests that stress stimuli, both acute and chronic, promote different physiological mechanisms and neuroendocrine responses. Oxytocin (OXT) is mainly synthesized in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. Central OXT has an anxiolytic effect and attenuates the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. Anti-stress effect of OXT has been explained by its inhibitory effect on corticotropin releasing factor (CRF) expression at the PVN via GABAA receptors. Repeated experience with the same stressor produces habituation, or diminution of behavioral responses and HPA axis responses. Up-regulated OXT expression in the PVN is involved in mediating habituation in response to chronic homotypic stress in rats. In contrast to chronic homotypic stress, no habituation is observed when rats are singly housed and received different types of stressors for 7 days (chronic heterotypic stress). Increased CRF expression and reduced OXT expression at the PVN are observed following chronic heterotypic stress in singly housed rats. Thus, it is conceivable that stress responses to chronic heterotypic stress would be diminished if endogenous OXT expression is upregulated. Various manual therapies such as massage, acupuncture and transcutaneous electrical nerve stimulation (TENS) involve the stimulation of somatosensory neurons. OXT system is activated by manual therapies. TENS increases OXT expression and decreases CRF expression at the PVN following chronic heterotypic stress in singly housed rats. OXT has been implicated in a number of social behaviors, including maternal care, affiliation and social attachment. Social attachment is known to stimulate OXT release in the hypothalamus in rats. A recent study demonstrates an increased OXT expression following chronic heterotypic stress when rats are pair-housed. Somatosensory stimulation is a promising treatment for stress-associated diseases. A social interaction is also important to adapt to our daily life stress.

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Transcutaneous electroacupuncture improves dyspeptic symptoms and increases high frequency heart rate variability in patients with functional dyspepsia

Cited by 102 publications

References 28 publications

Evidence-based clinical practice guidelines for functional dyspepsia

Evidence-based clinical practice guidelines for functional dyspepsia

Central and Peripheral Effects of Transcutaneous Acupuncture Treatment for Nausea in Patients with Diabetic Gastroparesis

Anti-stress Effect of Hypothalamic Oxytocin, Importance of Somatosensory Stimulation and Social Buffering

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