Transcutaneous Electrical Acustimulation Improves Gastrointestinal Disturbances Induced by Transcatheter Arterial Chemoembolization in Patients With Liver Cancers

Zhu, Ying; Li, Xianpeng; Ma, Jibo; Xu, Wenyi; Li, Miaomiao; Gong, Yuhan; Zhang, Bo; Chen, Ying; Sun, Chao; Xu, Qingcheng; Lin, Lin; Chen, Jiande D.Z.

doi:10.1111/ner.13158

Cited by 10 publications

(8 citation statements)

References 40 publications

(54 reference statements)

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“…For the stimulation of each acupoint, one electrode was placed right at the acupoint and the other electrode at 2 cm above or below the first electrode along the leg or the arm. Acupoint of PC6 is located at the one‐sixth of remote end and five‐sixth of the proximal end of the connection stripe between the transverse wrist crease and cubital crease 14 (Figure 1A). ST36 acupoint is located at the proximal one‐fifth of the craniolateral surface of the leg distal to the head of the tibia in a depression between the muscles of the cranial tibia and the long digital extensor 15 (Figure 1B).…”

Section: Methodsmentioning

confidence: 99%

“…Sham‐TEA was performed with the same stimulation parameters at sham points (non‐acupoints area): the sham‐point for PC6 was about 15 cm up (to the elbow) and laterals to PC6 and the sham‐point for ST36 was about 10 cm down (to the knee joint) and laterals to ST36 14 …”

Section: Methodsmentioning

confidence: 99%

“…A one-channel ECG was recorded via 3 cutaneous electrodes placed as follows: the right manubrium of the sternum, the fifth interspace in the left midclavicular line, and the right chest (the ground electrode). 14 The ECG signal was amplified via a special amplifier (ECG-201, Ningbo Maida Medical Device Inc.), then digitized by computer. The heart rate variability (HRV) signal was derived from the ECG by calculating R-R intervals using a previously validated software.…”

Section: Assessment Of Autonomic Functionsmentioning

confidence: 99%

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Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

Xuan

Zhu

et al. 2021

Neurogastroenterology Motil

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Background/Aims Gastrointestinal (GI) dysmotility in acute pancreatitis (AP) aggravates inflammation and results in severe complications. This study aimed to explore effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) on abdominal pain, GI dysmotility, and inflammation in AP patients. Methods Forty‐two AP patients were blindly randomized to receive TEA (n = 21) at acupoints PC6 and ST36 or Sham‐TEA (n = 21) at sham points for 2 days. Symptom scores, gastric slow waves, autonomic functions (assessed by spectral analysis of heart rate variability), circulatory levels of motilin, ghrelin, and TNF‐α were measured before and after the treatment. Sixteen healthy controls (HCs) were also included without treatment for the assessment of gastric slow waves and biochemistry. Key Results Compared with Sham‐TEA, TEA decreased abdominal pain score (2.57 ± 1.78 vs. 1.33 ± 1.02, p < 0.05), bloating score (5.19 ± 1.21 vs. 0.76 ± 0.99, p < 0.001), the first defecation time (65.79 ± 19.51 h vs. 51.38 ± 17.19 h, p < 0.05); TEA, but not Sham‐TEA, improved the percentage of normal gastric slow waves by 41.6% (p < 0.05), reduced AP severity score (5.52 ± 2.04 vs. 3.90 ± 1.90, p < 0.05) and serum TNF‐α (7.59 ± 4.80 pg/ml vs. 4.68 ± 1.85 pg/ml, p < 0.05), and upregulated plasma ghrelin (0.85 ± 0.96 ng/ml vs. 2.00 ± 1.71 ng/ml, p = 0.001) but not motilin (33.08 ± 22.65 pg/ml vs. 24.12 ± 13.95 pg/ml, p > 0.05); TEA decreased sympathetic activity by 15.0% and increased vagal activity by 18.3% (both p < 0.05). Conclusions & Inferences TEA at PC6 and ST36 administrated at early stage of AP reduces abdominal pain, improves GI motility, and inhibits inflammatory cytokine, TNF‐α, probably mediated via the autonomic and ghrelin mechanisms.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Assessment Of Autonomic Functionsmentioning

confidence: 99%

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Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

Xuan

Zhu

et al. 2021

Neurogastroenterology Motil

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“…An RCT of 60 patients treated with paclitaxel and carboplatin confirmed that the incidence of nausea, vomiting, and constipation was lower in the acupuncture group with no adverse events 2–5 days after chemotherapy, suggesting that acupuncture was better than tropisetron for the prevention and treatment of these symptoms during the delayed chemotherapy period and resulted in a better quality of life ( 42 ). In addition, daily TEAS at ST36 and PC6 after cisplatin chemotherapy in patients with liver cancer resulted in improved GI in the delayed phase, including nausea, bloating, impaired digestion, and constipation, and suggested that the mechanism may be related to vagal activity ( 43 ). Xie et al.…”

Section: Efficacy and Mechanisms Of Acupoint Stimulation In The Allev...mentioning

confidence: 99%

Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects

Zhao

Guo

et al. 2022

Front. Oncol.

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Although chemotherapy is the first-line treatment strategy for a variety of tumors, its side effects have limited its efficacy. This review summarizes the progress on the use of acupoint stimulation to combat chemotherapy-associated side effects, including chemotherapy-induced peripheral neuropathy (CIPN), cognitive impairment (CICI), and gastrointestinal toxicity (GI), as well as myelosuppression and immunosuppression. It was found that acupoint stimulation attenuated CIPN and GI by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the duodenum by reducing oxidative stress and neuroinflammation. Acupoint stimulation also alleviated GI by activating vagal activity in the nucleus tractus solitarius and promoting the secretion of gastrointestinal neuropeptide hormones. Acupoint stimulation restored both bone marrow hematopoiesis and immune function to combat cancer. In addition, the combination of acupoint stimulation and chemotherapy could inhibit tumor growth by promoting tumor cell apoptosis and the enrichment of chemotherapeutic agents in tumor tissue and by modulating the tumor immune microenvironment and normalizing the vasculature. Multiple evidence also indicates that neuroimmune regulation may be involved in the effects of acupoint stimulation. In conclusion, the evidence suggests that acupoint stimulation can alleviate the side effects of chemotherapy and can also assist chemotherapeutic agents in inhibiting tumor growth, which expands the clinical application of acupoint stimulation in cancer treatment. However, more high-quality clinical studies are needed to confirm the clinical value of acupoint stimulation.

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“…Based on titles and abstracts, we screened 121 final research articles, leaving 36 likely to be eligible. Following the fulltext reading, 27 articles were finally adopted [26][27][28][29][30][31][32]; some are In Chinese. e flow of this study is presented in Figure 1.…”

Section: Eligible Studies and Studymentioning

confidence: 99%

Analysis of Acupoints Combination for Cancer-Related Anorexia Based on Association Rule Mining

Tang

Liang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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We investigated the acupoint selection regulations and workable core acupoint combinations in cancer-related anorexia (CA) treatment. The Apriori algorithm, complemented by the FP-growth algorithm, was used to mine association rules based on retrieved randomized control trials (RCTs) and clinical control trials (CCTs). We searched the following databases for acupuncture treatment regimens for CA: PubMed, Embase, Cochrane Central, Web of Science, WanFang Data, VIP, China Journal Full-Text Database (CNKI), and SinoMed (CBM). We extracted acupoints prescriptions from the 27 enrolled RCTs and CCTs for analysis. There have been 38 acupoints refined from 27 prescriptions. The pinnacle three regularly chosen acupoints were Zusanli (ST36), Zhongwan (RN12), and Sanyinjiao (SP6). We investigated 10 association rules, and the consequences confirmed that {RN4} ≥ {RN12}, {PC6} ≥ {ST36}, {RN12, SP6} ≥ {RN4}, {HT7} ≥ {RN12}, and {DU20} ≥ {RN12} had been the most frequent associated rules in the adoption literature. Zusanli (ST36), Sanyinjiao (SP6), Guanyuan (RN4), Zhongwan (RN12), Neiguan (PC6), Shenmen (HT7), and Baihui (DU20) would be regarded as acupuncture prescriptions in the treatment of CA.

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Transcutaneous Electrical Acustimulation Improves Gastrointestinal Disturbances Induced by Transcatheter Arterial Chemoembolization in Patients With Liver Cancers

Cited by 10 publications

References 40 publications

Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects

Analysis of Acupoints Combination for Cancer-Related Anorexia Based on Association Rule Mining

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