Abstract:We investigated the acupoint selection regulations and workable core acupoint combinations in cancer-related anorexia (CA) treatment. The Apriori algorithm, complemented by the FP-growth algorithm, was used to mine association rules based on retrieved randomized control trials (RCTs) and clinical control trials (CCTs). We searched the following databases for acupuncture treatment regimens for CA: PubMed, Embase, Cochrane Central, Web of Science, WanFang Data, VIP, China Journal Full-Text Database (CNKI), and S… Show more
“…The loss of weight and muscle mass can be attributed to several factors such as decreased food intake, anorexia, insulin resistance, and low levels of anabolic hormones [ 6 ]. The involvement of the neuroendocrine system in cachexia and the role of the hypothalamus, pituitary gland, and adrenal gland in controlling appetite have recently gained attention in cancer cachexia study [ 16 – 21 ]. The hypothalamus is the key regulator of energy homeostasis, especially in fine-tuning the energy balance by delivering signals to coordinate food intake and vice versa, suppressing energy expenditure [ 22 ].…”
Section: Cancer Cachexia As a Multi-organ Syndromementioning
confidence: 99%
“…The hypothalamus is the key regulator of energy homeostasis, especially in fine-tuning the energy balance by delivering signals to coordinate food intake and vice versa, suppressing energy expenditure [ 22 ]. Hypothalamic neuropeptide Y (NPY) and agouti gene-related protein (AgRP) neurons induce appetite, whereas proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons suppress it [ 16 , 17 , 19 – 21 , 23 ]. Fig.…”
Section: Cancer Cachexia As a Multi-organ Syndromementioning
Muscle wasting is a consequence of physiological changes or a pathology characterized by increased catabolic activity that leads to progressive loss of skeletal muscle mass and strength. Numerous diseases, including cancer, organ failure, infection, and aging-associated diseases, are associated with muscle wasting. Cancer cachexia is a multifactorial syndrome characterized by loss of skeletal muscle mass, with or without the loss of fat mass, resulting in functional impairment and reduced quality of life. It is caused by the upregulation of systemic inflammation and catabolic stimuli, leading to inhibition of protein synthesis and enhancement of muscle catabolism. Here, we summarize the complex molecular networks that regulate muscle mass and function. Moreover, we describe complex multi-organ roles in cancer cachexia. Although cachexia is one of the main causes of cancer-related deaths, there are still no approved drugs for cancer cachexia. Thus, we compiled recent ongoing pre-clinical and clinical trials and further discussed potential therapeutic approaches for cancer cachexia.
“…The loss of weight and muscle mass can be attributed to several factors such as decreased food intake, anorexia, insulin resistance, and low levels of anabolic hormones [ 6 ]. The involvement of the neuroendocrine system in cachexia and the role of the hypothalamus, pituitary gland, and adrenal gland in controlling appetite have recently gained attention in cancer cachexia study [ 16 – 21 ]. The hypothalamus is the key regulator of energy homeostasis, especially in fine-tuning the energy balance by delivering signals to coordinate food intake and vice versa, suppressing energy expenditure [ 22 ].…”
Section: Cancer Cachexia As a Multi-organ Syndromementioning
confidence: 99%
“…The hypothalamus is the key regulator of energy homeostasis, especially in fine-tuning the energy balance by delivering signals to coordinate food intake and vice versa, suppressing energy expenditure [ 22 ]. Hypothalamic neuropeptide Y (NPY) and agouti gene-related protein (AgRP) neurons induce appetite, whereas proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons suppress it [ 16 , 17 , 19 – 21 , 23 ]. Fig.…”
Section: Cancer Cachexia As a Multi-organ Syndromementioning
Muscle wasting is a consequence of physiological changes or a pathology characterized by increased catabolic activity that leads to progressive loss of skeletal muscle mass and strength. Numerous diseases, including cancer, organ failure, infection, and aging-associated diseases, are associated with muscle wasting. Cancer cachexia is a multifactorial syndrome characterized by loss of skeletal muscle mass, with or without the loss of fat mass, resulting in functional impairment and reduced quality of life. It is caused by the upregulation of systemic inflammation and catabolic stimuli, leading to inhibition of protein synthesis and enhancement of muscle catabolism. Here, we summarize the complex molecular networks that regulate muscle mass and function. Moreover, we describe complex multi-organ roles in cancer cachexia. Although cachexia is one of the main causes of cancer-related deaths, there are still no approved drugs for cancer cachexia. Thus, we compiled recent ongoing pre-clinical and clinical trials and further discussed potential therapeutic approaches for cancer cachexia.
“…Machine-learning approaches have garnered significant attention in acupuncture and Chinese medicine due to their broad applications. These strategies employ various methods such as association analysis, correlation analysis, classification, and clustering to analyze extensive datasets and identify meaningful patterns and relationships (17)(18)(19)(20). In this paper, we first conducted a meta-analysis to assess the effectiveness of acupuncture for POI in CRC.…”
BackgroundPostoperative ileus (POI) is a common complication following abdominal surgery, which can lead to significant negative impacts on patients’ well-being and healthcare costs. However, the efficacy of current treatments is not satisfactory. The purpose of this study was to evaluate the therapeutic effects of acupuncture intervention and explore the regulation of acupoint selection for treating POI in colorectal cancer (CRC) patients.MethodsWe searched eight electronic databases to identify randomized controlled trials (RCTs) on acupuncture for POI in CRC and conducted a meta-analysis. Subsequently, we utilized the Apriori algorithm and the Frequent pattern growth algorithm, in conjunction with complex network and cluster analysis, to identify association rules of acupoints.ResultsThe meta-analysis showed that acupuncture led to significant reductions in time to first defecation (MD=-20.93, 95%CI: -25.35, -16.51; I2 = 93.0%; p < 0.01; n=2805), first flatus (MD=-15.08, 95%CI: -18.39, -11.76; I2 = 96%; p < 0.01; n=3284), and bowel sounds recovery (MD=-10.96, 95%CI: -14.20, -7.72; I2 = 94%; p < 0.01; n=2043). A subgroup analysis revealed that acupuncture not only reduced the duration of POI when administered alongside conventional care but also further expedited the recovery of gut function after colorectal surgery when integrated into the enhanced recovery after surgery (ERAS) pathway. The studies included in the analysis reported no instances of serious adverse events associated with acupuncture. We identified Zusanli (ST36), Shangjuxu (ST37), Neiguan (PC6), Sanyinjiao (SP6), Xiajuxu (ST39), Hegu (LI4), Tianshu (ST25), and Zhongwan (RN12) as primary acupoints for treating POI. Association rule mining suggested potential acupoint combinations including {ST37, ST39}≥{ST36}, {PC6, ST37}≥{ST36}, {SP6, ST37}≥{ST36}, and {ST25, ST37}≥{ST36}.ConclusionMeta-analysis indicates acupuncture’s safety and superior effectiveness over postoperative care alone in facilitating gastrointestinal recovery. Machine-learning approaches highlight the importance of the lower He-sea points, including Zusanli (ST36) and Shangjuxu (ST37), in treating POI in CRC patients. Incorporating additional acupoints such as Neiguan (PC6) (for pain and vomiting) and Sanyinjiao (SP6) (for abdominal distension and poor appetite) can optimize treatment outcomes. These findings offer valuable insights for refining treatment protocols in both clinical and experimental settings, ultimately enhancing patient care.
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