Transcutaneous electrical acupoint stimulation (TEAS) ameliorates chemotherapy-induced bone marrow suppression in lung cancer patients

Hou, Lili; Gu, Fangyi; Gao, Guanghui; Zhou, Cai-cun

doi:10.21037/jtd.2017.03.12

Cited by 15 publications

(18 citation statements)

References 9 publications

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“…Some studies [ 20 ] suggested that simultaneous stimulation at BL17, SP6, and LI4 can be used for the treatment of primary thrombocytopenic purpura, which could significantly improve the clinical symptoms of patients and promote recovery of platelet counts. Electrical acupoint stimulation at SP6 can nourish the Yin and blood.…”

Section: Discussionmentioning

confidence: 99%

Randomized Efficacy Trial of Conventional, TCM Herb, and TEAS on Bone Marrow Suppression in Patients with Small Cell Lung Cancer after Initial Chemotherapy

Zhao

Wang

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To compare the efficiency of transcutaneous electrical acupoint stimulation (TEAS) with those of conventional and TCM herb on bone marrow suppression in small cell lung cancer (SCLC) patients after initial chemotherapy. Methods. We recruited 139 participants with pathologically confirmed SCLC who had not received chemotherapy. The conventional group (n = 37) received gemcitabine and cisplatin chemotherapy and routine care. The TCM herb group (n = 35) received 3 Diyushengbai tablets thrice a day for one day prior to chemotherapy and maintained during the trial. The TEAS group (n = 42) received TEAS at a frequency of 65–100 Hz with a pulse width of 100–200 μsec. Acupoints were selected from Dazhui (DU14), Geshu (BL17), Zusanli (ST36), Sanyinjiao (SP6), and Hegu (LI4) and were treated on days 1, 2, 3, 5, 8, 14, 21, and 28 of chemotherapy for 30 min each day. All three groups underwent a 28-day treatment for a total of one treatment course. Changes in the white blood cell, neutrophil, platelet, and hemoglobin indices on day 1 before chemotherapy and days 5, 8, 11, 14, 21, and 28 days after chemotherapy were compared among the groups. Comfort levels of patients on day 1 before chemotherapy and days 5, 11, and 21 after chemotherapy were observed. Results. Compared with the conventional group, the white blood cell counts in the TEAS group on days 8 (7.07 ± 2.11 vs. 5.97 ± 2.10 × 109/L) and 14 (6.14 ± 1.51 vs. 5.07 ± 2.41 × 109/L) of chemotherapy and that in the TCM herb group on day 14 (6.63 ± 3.44 vs. 5.07 ± 2.41 × 109/L) of chemotherapy were increased ( P < 0.05 ). Compared with the conventional group, the neutrophil count in the TEAS group on days 5 (4.28 ± 1.54 vs. 3.01 ± 1.41 × 109/L), 8 (3.75 ± 1.21 vs. 2.77 ± 1.17 × 109/L), 11 (3.46 ± 1.31 vs. 2.31 ± 1.24 × 109/L), 14 (3.18 ± 1.29 vs. 2.07 ± 1.14 × 109/L), and 21 (4.67 ± 1.31 vs. 3.58 ± 1.23 × 109/L) of chemotherapy and that in the TCM herb group on day 5 (3.88 ± 1.05 vs. 3.01 ± 1.41 × 109/L) of chemotherapy were increased ( P < 0.05 ). Compared with the conventional group, the platelet count of patients in the TEAS group increased on days 5 (264.7 ± 64.1 vs. 201.0 ± 55.7 × 109/L), 8 (251.3 ± 74.9 vs. 188.2 ± 65.8 × 109/L), 11 (236.7 ± 74.9 vs. 181.3 ± 84.3 × 109/L), and 14 (238.3 ± 75.9 vs. 192.8 ± 95.8 × 109/L) of chemotherapy ( P < 0.05 ). Compared with the TCM herb group, the platelet count in the TEAS group increased on days 5 (264.7 ± 64.1 vs. 216.3 ± 57.9 × 109/L), 8 (251.3 ± 74.9 vs. 213.7 ± 70.3 × 109/L), 11 (236.7 ± 74.9 vs. 181.3 ± 84.3 × 109/L), and 21 (254.8 ± 81.8 vs. 213.9 ± 82.6 × 109/L) of chemotherapy ( P < 0.05 ). Compared with the conventional group, the hemoglobin level in the TCM herb group increased on day 14 (135.03 ± 28.06 vs. 122.09 ± 12.63 g/L) of chemotherapy ( P < 0.05 ). Compared with the conventional group, the comfort score of the TEAS group increased on days 5 (78.31 ± 10.21 vs. 70.18 ± 9.34 score) and 11 (80.07 ± 10.44 vs. 72.11 ± 9.47 score) of chemotherapy ( P < 0.05 ). Conclusion. TEAS is an effective and safe treatment modality for improving bone marrow suppression in SCLC patients after initial chemotherapy. TEAS improved comfort levels more effectively than did conventional and TCM herb.

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Section: Discussionmentioning

confidence: 99%

Randomized Efficacy Trial of Conventional, TCM Herb, and TEAS on Bone Marrow Suppression in Patients with Small Cell Lung Cancer after Initial Chemotherapy

Zhao

Wang

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Points ST-36 and SP-6 together with points DU-14 (Dazhui), BL-14 (Geshu), and LI-14 (Hegu) according to Hou et al [15] can reduce bone marrow suppression and be able to enrich the blood, especially an increase in total leukocytes. This study did not show a significant effect on the increase in erythrocytes in patients with myelosuppression due to the use of chemotherapy drugs.…”

Section: Discussionmentioning

confidence: 99%

“…The sample used was 191 patients with 52 patients in the acupuncture treatment group. Hou et al [15] said that to get results in the form of an increase in total erythrocyte and haemoglobin, it would be better to increase the sample size and extend the frequency or repetition of acupuncture such as more than 120 days.…”

Section: Discussionmentioning

confidence: 99%

Study of the Effect of Electroacupuncture Combination in Total Erythrocyte, Hemoglobin, and Hematocrite Values in Domestic Cat

Ritonga¹,

Jalaluddin²,

Sari³

et al. 2021

Advances in Biological Sciences Research

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Acupuncture is an alternative treatment originating from China. According to Traditional Chinese Medicine (TCM) the condition of blood insufficiency including blood deficiency and blood stagnation. The study aimed to determine the effect of electroacupuncture on erythrocyte number, haemoglobin level and hematocrit value in the domestic cat (Felis domesticus). This study used an experimental method with 6 domestic cats divided into 2 treated groups consisting of group A and group B. Group A received electroacupuncture stimulation of acupoint including BL-18 (Ganshu), SP-6 (Sanyinjiao), SI-3 (Houxi) and group B received electroacupuncture stimulation of acupoint including ST-36 (Housanli), BL-19 (Danshu), LIV-3 (Taichong). The duration of the electroacupuncture is 5 times with a period of 3 days. The blood was examined before (pre-test) and after (post-test) the electroacupuncture treatment using haematology analyzer. Data were analyzed using the Paired-Samples T-Test. The result of the study showed there are no significant differences of erythrocyte number, haemoglobin level and hematocrit level on group A and group B (p>0.05). The conclusion is that electroacupuncture does not have a significant effect on total erythrocytes, hemoglobin levels and hematocrit values in domestic cats.

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“…The main objective of the SR is to evaluate the efficacy and safety of acupuncture for chemotherapy induced marrow suppression; therefore, the primary outcomes are as follows: white blood cell (WBC) counts, [ 24 ] platelet counts, [ 25 ] hemoglobin counts, [ 26 ] or other validated outcome measures.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture for the treatment of marrow suppression after chemotherapy

Geng

Yin²,

Sun³

et al. 2020

Medicine

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Background: Cancer continues to be a severe global health problem and the leading cause of death worldwide. Chemotherapy as the main treatment has various side effects, of which marrow suppression is the most common one. Acupuncture had shown clinical effects for marrow suppression after chemotherapy in many studies. However, the efficacy and safety of acupuncture therapy for marrow suppression after chemotherapy remains unclear. Objective: This protocol aims to evaluate the efficacy and safety of acupuncture for marrow suppression after chemotherapy according to the existing randomized controlled trials. Methods and analysis: The randomized controlled trials on acupuncture therapy for marrow suppression after chemotherapy will be searched in the database of Embase, PubMed and Cochrane Library, Allied and Complementary Medicine Database (AMED), Chinese Biomedical Literature Database (CBM), China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), WanFang Database (WF), and related registration platforms (WHO ICTRP, Clinical Trials, and Chinese Clinical Trial Register [ChiCTR]), Grey Literature Database from inception to 1 August 2020. The primary outcomes will be assessed using white blood cell (WBC) count, platelet count, hemoglobin count and the number of neutrophils (N). Review Manager V.5.3 software will be applied for statistical analyses. We will measure the risk of bias of the included studies with Cochrane Collaboration Risk of Bias Tool. Finally, Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) will be used to grade the overall quality of evidence. And we will use the intra-group correlation coefficient to assess the consistency of reviewers. Result: This systematic review and meta-analysis will put a high-quality synthesis of the efficacy and safety of acupuncture treatment in marrow suppression after chemotherapy. Conclusion: The conclusion of this systematic review will provide evidence to assess acupuncture therapy is an efficacy and safe intervention to treat and control marrow suppression after chemotherapy. PROSPERO registration number: PROSPERO CRD42020163336

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Transcutaneous electrical acupoint stimulation (TEAS) ameliorates chemotherapy-induced bone marrow suppression in lung cancer patients

Cited by 15 publications

References 9 publications

Randomized Efficacy Trial of Conventional, TCM Herb, and TEAS on Bone Marrow Suppression in Patients with Small Cell Lung Cancer after Initial Chemotherapy

Randomized Efficacy Trial of Conventional, TCM Herb, and TEAS on Bone Marrow Suppression in Patients with Small Cell Lung Cancer after Initial Chemotherapy

Study of the Effect of Electroacupuncture Combination in Total Erythrocyte, Hemoglobin, and Hematocrite Values in Domestic Cat

Acupuncture for the treatment of marrow suppression after chemotherapy

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