Transcriptomic profiling revealed the role of apigenin-4′-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK signaling pathway

Cao, Dan; Fan, Qiqi; Li, Zhiqi; Chen, Meilin; Jiang, Yangyu; Lin, Rui‐Chao; Li, Jian; Zhao, Chongjun

doi:10.1016/j.phymed.2022.154201

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…MAPKs are activated by a cascade of phosphorylation events, wherein activated mitogen-activated protein kinase kinase kinase (MAPKKK) phosphorylates mitogen-activated protein kinase kinase (MAPKK), which finally phosphorylates MAPK ( 100 ). IL-1β, IL-6, TNF, TGF-β, and TPA up-regulates AP-1 through the MAPK pathway ( 101 , 102 ). ERK1/2 is activated through a signaling cascade via phosphorylation of Ras, Raf, and MEK 1/2 ( 98 ).…”

Section: Ap-1mentioning

confidence: 99%

“…Antcin K is an extract taken from a medicinal mushroom, Antrodia cinnamomea , that inhibits vascular cell adhesion molecule 1 (VCAM-1) and monocyte adhesion to RASFs by inhibiting the phosphorylation of p38 and MEK1/2-ERK ( 122 ). Apigenin-4 ´ -O-α-L-rhamnoside, a natural flavonoid, exhibits inhibitory mechanisms against MMP1, MMP3, TNF, and RNAKL in RA FLS by inhibiting the MAPK/JNK/p38 pathway ( 102 ). Anticin K and Apigenin-4 ´ -O-α-L-rhamnoside inhibit the inflammatory mediators of AP-1 and indirectly suppress the activation of AP-1.…”

Section: Ap-1mentioning

confidence: 99%

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Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

et al. 2023

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Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating RA patients are aimed at halting the progression of the disease and alleviating inflammation. Further, some of these treatment options have drawbacks, including disease recurrence and adverse effects due to long-term use. These inefficiencies have created a need for a different approach to treating RA. Recently, the focus has shifted to direct targeting of transcription factors (TFs), as they play a vital role in the pathogenesis of RA, activating key cytokines, chemokines, adhesion molecules, and enzymes. In light of this, synthetic drugs and natural compounds are being explored to target key TFs or their signaling pathways in RA. This review discusses the role of four key TFs in inflammation, namely NF-κB, STATs, AP-1 and IRFs, and their potential for being targeted to treat RA.

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Section: Ap-1mentioning

confidence: 99%

Section: Ap-1mentioning

confidence: 99%

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

et al. 2023

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“…Studies have shown that CC can treat a variety of arthritis, and it is better for OA, RA and GA. CC has the characteristics of multiple components, multiple targets, and multiple pathways in the treatment of arthritis. Currently, IL-10, IL-1β, IL-6, MMP-3, TNF-α and other targets have been verified to play a role in treating arthritis by CC ( Table 2 ) ( Sun et al, 2011 ; Yuan et al, 2014 ; Kienhorst et al, 2015 ; Huang et al, 2019 ; Thomas, 2020 ; Che et al, 2021 ; Li et al, 2021 ; Wu et al, 2021 ; Arra et al, 2022 ; Zhang et al, 2022 ; Cao et al, 2022 ; Du et al, 2022 ; Pacifici, 2022 ; Wirth et al, 2022 ; Xiao et al, 2022 ; Yang et al, 2022 ; Sun et al, 2023a ; Barbarroja et al, 2023 ; Li et al, 2023 ; Brix et al, 2023 ; Wang et al, 2023b ; Wang et al, 2023 ; Ghosh et al, 2023 ; González-Chávez et al, 2023 ; Hecquet et al, 2023 ; Jahantigh et al, 2023 ; Ji et al, 2023 ; La Bella et al, 2023 ; Leung et al, 2023 ; Lin et al, 2023 ; Luo et al, 2023 ; Zeng et al, 2023 ; Zhang et al, 2023 ). However, the types of arthritis treated with these targets are not completely clear.…”

Section: Deep Exploration Based On Potential Therapeutic Targets For ...mentioning

confidence: 99%

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

Tian

Guo

et al. 2023

Front. Pharmacol.

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Arthritis is a common degenerative disease of joints, which has become a public health problem affecting human health, but its pathogenesis is complex and cannot be eradicated. Coptis chinensis (CC) has a variety of active ingredients, is a natural antibacterial and anti-inflammatory drug. In which, berberine is its main effective ingredient, and has good therapeutic effects on rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis (GA). RA, OA and GA are the three most common types of arthritis, but the relevant pathogenesis is not clear. Therefore, molecular mechanism and prevention and treatment of arthritis are the key issues to be paid attention to in clinical practice. In general, berberine, palmatine, coptisine, jatrorrhizine, magnoflorine and jatrorrhizine hydrochloride in CC play the role in treating arthritis by regulating Wnt1/β-catenin and PI3K/AKT/mTOR signaling pathways. In this review, active ingredients, targets and mechanism of CC in the treatment of arthritis were expounded, and we have further explained the potential role of AHR, CAV1, CRP, CXCL2, IRF1, SPP1, and IL-17 signaling pathway in the treatment of arthritis, and to provide a new idea for the clinical treatment of arthritis by CC.

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Panlongqi tablet suppresses adjuvant-induced rheumatoid arthritis by inhibiting the inflammatory reponse in vivo and in vitro

Niu

Yang

et al. 2023

Journal of Ethnopharmacology

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Transcriptomic profiling revealed the role of apigenin-4′-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK signaling pathway

Cited by 4 publications

References 44 publications

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

Panlongqi tablet suppresses adjuvant-induced rheumatoid arthritis by inhibiting the inflammatory reponse in vivo and in vitro

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