Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes

Morrissette, Jovane Hamelin; Tremblay, Dominic; Marcotte‐Chénard, Alexis; Lizotte, Farah; Brunet, Marie-Christine; Beaugerie, Laurent; Riesco, Éléonor; Geraldes, Pedro

doi:10.1007/s00421-022-04911-9

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Details are described in the Supplemental Material and have also been described previously (32,34,35).…”

Section: Methodsmentioning

confidence: 99%

“…and immunochemistry -Details are described in the Supplemental Material and as previously described 32,34,35 .…”

Section: Culture Cell and Immunofluorescence Isolation Of Human Blood...mentioning

confidence: 99%

“…Culture Cell and Immunofluorescence, Isolation of Human Blood Monocytes, Quantitative PCR, and Immunochemistry Details are described in the Supplemental Material and have also been described previously (32,34,35).…”

Section: Blood Sample Collectionmentioning

confidence: 99%

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Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes

et al. 2022

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Background - Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease worldwide. Despite significant advances in kidney care, there is a need to improve non-invasive techniques to better predict the progression of kidney disease for patients with diabetes. Following injury, podocytes are shed in urine and may be used as a biological tool. We previously reported that SHP-1 is upregulated in the kidney of diabetic mice leading to podocyte dysfunction and loss. Our objective was to evaluate the expression levels of SHP-1 in urinary podocytes and kidney tissues of diabetic patients. Methods - In this prospective study, patients with and without diabetes were recruited for the quantification of SHP-1 in kidney tissues, urinary podocytes and peripheral blood monocytes. Immunochemistry and mass spectrometry techniques were applied for kidney tissues. Urinary podocytes were counted, and expression of SHP-1 and podocyte markers were measured by quantitative PCR. Results - A total of 66 participants (diabetic n=48, nondiabetic n=18) were included in the analyses. Diabetes was associated with increased SHP-1 expression in kidney tissues (P = 0.0286). Nephrin and podocin mRNA were not significantly increased in urinary podocytes from patients with diabetes compared to those without diabetes, whereas levels of SHP-1 mRNA expression significantly correlated with HbA1c and estimated glomerular filtration rate (eGFR). Additionally, follow-up (up to 2 years post recruitment) evaluation indicated that SHP-1 mRNA expression continued to increase with eGFR decline. Conclusions - Levels of SHP-1 in urinary podocytes may serve as an additional marker of glomerular disease progression in this population.

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“…Details are described in the Supplemental Material and have also been described previously (32,34,35).…”

Section: Methodsmentioning

confidence: 99%

“…and immunochemistry -Details are described in the Supplemental Material and as previously described 32,34,35 .…”

Section: Culture Cell and Immunofluorescence Isolation Of Human Blood...mentioning

confidence: 99%

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Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes

et al. 2022

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“…Recent European Journal of Applied Physiology publications indicate how different exercise strategies can improve physiological responses in people with type 2 diabetes. High-intensity interval training (HIIT) combined with or without resistance training can favorably down-regulate micro RNAs that are controllers of inflammation and muscle atrophy (Ghodrat et al 2022 ), and down-regulate gene expression associated with atherosclerosis (Hamelin Morrissette et al 2022 ). Either HIIT or traditional moderate-intensity continuous training is effective for improving peripheral oxygen extraction during exercise in diabetics (Ryckeghem et al 2022 ).…”

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confidence: 99%

The role of exercise physiology in the United Nations’ sustainable development goals

Chilibeck

2023

Eur J Appl Physiol

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The impact of high-intensity interval training on women’s health: A bibliometric and visualization analysis

Li,

Fang

2024

Medicine

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Background: High-intensity interval training (HIIT) can significantly improve health indicators such as cardiopulmonary function, metabolic efficiency, and muscle strength in a short period. However, due to significant physiological and metabolic differences between males and females, the effects of HIIT vary between genders. Therefore, exploring the specific impacts of HIIT on women’s health is crucial. Although there is a considerable amount of individual research on the impact of HIIT on women’s health, a systematic bibliometric analysis is still lacking. Methods: Publications related to HIIT in women’s health were retrieved from the Web of Science Core Collection database, and tools like Microsoft Office Excel 2021, VOSviewer, and Citespace were used to create visualized tables and views. Results: The study included 808 publications distributed across 1234 institutions in 61 countries, authored by 3789 researchers. The United States, Australia, and Canada lead in this domain. Researchers like Astorino TA and Gibala MJ are notably influential in this field. The research has been prominently published in specific academic journals and widely cited by high-impact journals. Highly cited and bursting documents primarily discuss the effects of HIIT on metabolic adaptation, muscle adaptation, cardiovascular health, insulin sensitivity, and exercise performance. Frequent keywords include “aerobic exercise,” “sprint interval training,” “resistance training,” “obesity,” “body composition,” “aging,” and “insulin resistance.” Keyword burst analysis reveals that early studies focused primarily on basic concepts and training models, which then expanded to specific physiological responses, applications in particular populations, and impacts on specific diseases. Conclusion: This field has emerged as a research hotspot with international characteristics and extensive academic productivity. Journals and cited journals hold high academic influence, with highly cited and bursty references laying a solid theoretical and practical foundation for the field. In the rapid development of the past decade, research hotspots and frontier directions such as metabolic adaptation, muscle adaptation, cardiovascular health, exercise performance, and personalized training plans have been formed.

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Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes

Cited by 3 publications

References 46 publications

Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes

Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes

The role of exercise physiology in the United Nations’ sustainable development goals

The impact of high-intensity interval training on women’s health: A bibliometric and visualization analysis

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