Transcriptome regulation by PARP13 in basal and antiviral states in human cells

Busa, Veronica F.; Ando, Yoshinari; Aigner, Stefan; Yee, Brian A.; Yeo, Gene W.; Leung, Anthony K.L.

doi:10.1016/j.isci.2024.109251

iScience

2024

DOI: 10.1016/j.isci.2024.109251

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Transcriptome regulation by PARP13 in basal and antiviral states in human cells

Veronica F. Busa,

Yoshinari Ando,

Stefan Aigner

et al.

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2024

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Cited by 1 publication

References 53 publications

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Endogenous ZAP is associated with altered global cellular gene expression during Zika virus infection

Khanh Le,

Singh,

Sabir

et al. 2024

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The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. Previous RNA-seq analyses were conducted in uninfected wild-type and ZAP-KO cells; however, the impact of ZAP on global gene expression during virus infection remains unknown. Here, we characterized global cellular gene expression in uninfected and Zika virus-infected wild-type and ZAP knockout VERO cells. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response. We found that ZAP was associated with the inhibition of Zika virus in the absence of a robust type I IFN system (VERO cells are deficient for IFN-alpha and -beta). Also, during Zika infection in VERO cells endogenous ZAP was associated with amplification of global transcriptional antiviral responses in the absence of a robust type I IFN system. Further studies are warranted to elucidate this type I IFN-independent antiviral activity directly or indirectly mediated by ZAP.

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Endogenous ZAP is associated with altered global cellular gene expression during Zika virus infection

Khanh Le,

Singh,

Sabir

et al. 2024

Preprint

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Transcriptome regulation by PARP13 in basal and antiviral states in human cells

Cited by 1 publication

References 53 publications

Endogenous ZAP is associated with altered global cellular gene expression during Zika virus infection

Endogenous ZAP is associated with altered global cellular gene expression during Zika virus infection

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