Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model

Reed, Dominique; Kumar, Dileep; Kumar, Sushil; Raina, Komal; Punia, Reenu; Kant, Rama; Saba, Laura; Cruickshank‐Quinn, Charmion; Tabakoff, Boris; Reisdorph, Nichole; Edwards, Michael G.; Wempe, Michael F.; Agarwal, Chapla; Agarwal, Rajesh

doi:10.1016/j.jtcme.2021.08.011

Cited by 7 publications

(1 citation statement)

References 114 publications

(182 reference statements)

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“…Nutritional metabolomics offers investigations on the application of plant-derived small molecule metabolite profiling to address the complexity of the diet, nutrition, metabolome and health issues [ 105 ]. Both the targeted and non-targeted metabolomics of vegetables like tomato [ 106 ] and bitter melon ( Momordica charantia ) [ 107 ] has implications of advancing nutritional crops [ 108 ] by identifying and quantifying nutri-chemicals directly linked with the human diet and nutrition [ 109 ]. Comprehensive metabolomic profiling of ripened fruit collection of 32 chilli accessions using nontargeted LC-MS and GC-MS platforms identified 88 semi-polar metabolites.…”

Section: Application Of Metabolomics In Vegetable Cropsmentioning

confidence: 99%

Metabolomics-Driven Mining of Metabolite Resources: Applications and Prospects for Improving Vegetable Crops

Singh

Bisen

Shukla

et al. 2022

IJMS

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Vegetable crops possess a prominent nutri-metabolite pool that not only contributes to the crop performance in the fields, but also offers nutritional security for humans. In the pursuit of identifying, quantifying and functionally characterizing the cellular metabolome pool, biomolecule separation technologies, data acquisition platforms, chemical libraries, bioinformatics tools, databases and visualization techniques have come to play significant role. High-throughput metabolomics unravels structurally diverse nutrition-rich metabolites and their entangled interactions in vegetable plants. It has helped to link identified phytometabolites with unique phenotypic traits, nutri-functional characters, defense mechanisms and crop productivity. In this study, we explore mining diverse metabolites, localizing cellular metabolic pathways, classifying functional biomolecules and establishing linkages between metabolic fluxes and genomic regulations, using comprehensive metabolomics deciphers of the plant’s performance in the environment. We discuss exemplary reports covering the implications of metabolomics, addressing metabolic changes in vegetable plants during crop domestication, stage-dependent growth, fruit development, nutri-metabolic capabilities, climatic impacts, plant-microbe-pest interactions and anthropogenic activities. Efforts leading to identify biomarker metabolites, candidate proteins and the genes responsible for plant health, defense mechanisms and nutri-rich crop produce are documented. With the insights on metabolite-QTL (mQTL) driven genetic architecture, molecular breeding in vegetable crops can be revolutionized for developing better nutritional capabilities, improved tolerance against diseases/pests and enhanced climate resilience in plants.

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