Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation

Ying, Jun; Wang, Jian; Ji, Huijuan; Lin, Chaoqing; Pan, Ruowang; Zhou, Li; Song, Yulong; Zhang, Enyong; Ren, Ping; Chen, Jishun; Liu, Qian; Xu, Teng; Yi, Huiguang; Li, Jinsong; Bao, Qiyu; Hu, Yunliang; Li, Peizhen

doi:10.1016/j.gene.2016.03.023

Cited by 31 publications

(26 citation statements)

References 28 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, it has been reported that the dysfunction of cell cycle regulation appears to be closely connected to tumour onset and development. The G 2 /M checkpoint allows the cell to repair DNA damage before entering mitosis and is the most conspicuous target for many anticancer drugs that would cause cell death through the induction of apoptosis [54]. In this study, 4% betaine treatment induced cell cycle arrest in G 2 /M phase, preventing a further proliferation of cancer cells, as similarly observed in HeLa cells [35], in correlation with the observed decrease of cell viability seen in the MTT assay.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al [58] have also demonstrated that C-PC could inhibit tumour cell proliferation and induce G 2 /M phase arrest in HepG-2 cells. Ying et al [54] reported that C-PC displayed a significant inhibition effect on the proliferation of human ovarian cancer cell SKOV-3 in vitro , which was a result of interactions among multiple pathways and signalling molecules. For these authors, interfering with a series of signalling pathways including proteoglycans in cancer, neurotrophin signalling pathway, VEGF signalling pathway, central carbon metabolism in cancer, and p53 pathway and many ending executive factors such as cyclin B1, cyclin-dependent kinase 2 (Cdc2) and Cdc25C, and C-PC influenced the proliferation and apoptosis of cancer cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Bingula

Dupuis

Pichon

et al. 2016

Journal of Oncology

View full text Add to dashboard Cite

We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells. In vivo studies were performed in pathogen-free male nude rats injected with A549 cells in their right flank. Their daily food was supplemented with either betaine, C-PC, both, or neither. Compared to the control group, tumour weights and volumes were significantly reduced in either betaine- or C-PC-treated groups and no additional decrease was obtained with the combined treatment. This data indicates that C-PC and betaine alone may efficiently inhibit tumour growth in rats. The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro remains to be further confirmed in vivo. The reason behind the nature of their interaction is yet to be sought.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Bingula

Dupuis

Pichon

et al. 2016

Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…In addition, Gaoyong Liao found that phycocyanin blocked G2 / M cell cycle progression and induced apoptosis of PANC-1 cells 81 . Jun Ying proved that phycocyanin led to G2 / M phase arrest of SKOV-3 cells 88 . Chunyan Wang also confirmed that phycocyanin caused cell cycle G2 / M arrest and induced apoptosis in human hepatoma cell line HepG2 56 .…”

Section: Phycocyanin and Cancermentioning

confidence: 99%

Phycocyanin: A Potential Drug for Cancer Treatment

et al. 2017

View full text Add to dashboard Cite

Phycocyanin isolated from marine organisms has the characteristics of high efficiency and low toxicity, and it can be used as a functional food. It has been reported that phycocyanin has anti-oxidative function, anti-inflammatory activity, anti-cancer function, immune enhancement function, liver and kidney protection pharmacological effects. Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. So far, there are more and more studies have shown that phycocyanin has the anti-cancer effect, which can block the proliferation of cancer cells and kill cancer cells. Phycocyanin exerts anti-cancer activity by blocking tumor cell cell cycle, inducing tumor cell apoptosis and autophagy, thereby phycocyanin can serve as a promising anti-cancer agent. This review discusses the therapeutic use of phycocyanin and focuses on the latest advances of phycocyanin as a promising anti-cancer drug.

show abstract

“…Several studies have demonstrated that phycocyanin has bioactivity in kinds of cancers, including breast cancer [ 6 , 12 ], histiocytic tumor [ 13 ], ovarian cancer [ 14 ], colon cancer [ 15 ], prostate cancer [ 16 ], melanoma, and lung cancer [ 17 ]. Among them, lung cancer is one of the most common health threats in the world, especially given its high mortality rates [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Hao

Yan

et al. 2018

Marine Drugs

View full text Add to dashboard Cite

Phycocyanin, a type of functional food colorant, is shown to have a potent anti-cancer property. Non-small cell lung cancer (NSCLC) is one of the most aggressive form of cancers with few effective therapeutic options. Previous studies have demonstrated that phycocyanin exerts a growth inhibitory effect on NSCLC A549 cells. However, its biological function and underlying regulatory mechanism on other cells still remain unknown. Here, we investigated the in vitro function of phycocyanin on three typical NSCLC cell lines, NCI-H1299, NCI-H460, and LTEP-A2, for the first time. The results showed that phycocyanin could significantly induce apoptosis, cell cycle arrest, as well as suppress cell migration, proliferation, and the colony formation ability of NSCLC cells through regulating multiple key genes. Strikingly, phycocyanin was discovered to affect the cell phenotype through regulating the NF-κB signaling of NSCLC cells. Our findings demonstrated the anti-neoplastic function of phycocyanin and provided valuable information for the regulation of phycocyanin in NSCLC cells.

show abstract

Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation

Cited by 31 publications

References 28 publications

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Phycocyanin: A Potential Drug for Cancer Treatment

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Contact Info

Product

Resources

About