Phycocyanin: A Potential Drug for Cancer Treatment

Jiang, Linfeng; Wang, Yujuan; Yin, Qi-Feng; Liu, Guoxiang; Liu, Huihui; Huang, Yajing; Li, Bing

doi:10.7150/jca.21058

Cited by 170 publications

(100 citation statements)

References 135 publications

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“…Thus, this active compound of Spirulina extract can inhibit EMT and decrease cancer cells mobility and invasion. (Jiang et al, ; Pattarayan, Rajarajan, Ayyanar, Palanichamy, & Subbiah, ) Cyclooxygenase‐2 (COX‐2) plays critical role in cancer cells metastasis. The expression of COX‐2 was positively correlated with tumor invasion, metastasis, and poor prognosis in different cancers.…”

Section: Discussionmentioning

confidence: 99%

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Kefayat

Ghahremani

Safavi

et al. 2019

Phytotherapy Research

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Spirulina platensis extracts have exhibited considerable anti-cancer effects. To investigate the efficacy of the Spirulina extract enriched for Braun-type lipoprotein (Immulina®) for breast cancer treatment, 4T1 breast tumor-bearing mice were treated with 40 mg/kg Immulina® daily and the tumors' growth and metastasis were assessed. Also, CD4, CD8, and CD56 staining were performed to investigate the Immulina® effect on the immune cells' recruitment to the tumors by immunohistochemistry. Immulina® could significantly (P < 0.001) inhibit 4T1 breast tumors' growth. Immulina®-treated group exhibited a 63% decrease in the tumors' volume in comparison with control (P < 0.001). Also, Immulina® could significantly (P < 0.001) decrease metastatic burden at the vital organs as 68% and 61% decrease in the liver and lungs metastatic colonies were observed, respectively. Also, Immulina® could increase mean survival time of the tumor-bearing mice for 29 days.The Spirulina-treated mice tumors contained significantly more infiltrated NK, CD4+, and CD8+ T lymphocytes in comparison with control. Taking together, Immulina® can be a safe anti-cancer supplement with the ability to cause direct apoptosis to the cancer cells and activate the immune system against tumor. This supplement with natural origin seems to have bright future to help breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Kefayat

Ghahremani

Safavi

et al. 2019

Phytotherapy Research

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“…Phycobiliproteins, responsible for the characteristic bright pink appearance of red algae, are classified into phycoerythrin (red) and phycocyanin (blue). These pigments are used commercially in food, nutraceuticals, and for their therapeutic properties, mainly antimicrobial, antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, immuno-modulatory and anticancer effects [67][68][69][70][71][72]. Such compounds may improve the efficacy of standard anticancer drugs, decrease their side effects, and act as photosensitisers for the treatment of tumour cells [30].…”

Section: Other Bioactive Compounds From Marine Seaweedsmentioning

confidence: 99%

Potential Use of Marine Seaweeds as Prebiotics: A Review

et al. 2020

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Human gut microbiota plays an important role in several metabolic processes and human diseases. Various dietary factors, including complex carbohydrates, such as polysaccharides, provide abundant nutrients and substrates for microbial metabolism in the gut, affecting the members and their functionality. Nowadays, the main sources of complex carbohydrates destined for human consumption are terrestrial plants. However, fresh water is an increasingly scarce commodity and world agricultural productivity is in a persistent decline, thus demanding the exploration of other sources of complex carbohydrates. As an interesting option, marine seaweeds show rapid growth and do not require arable land, fresh water or fertilizers. The present review offers an objective perspective of the current knowledge surrounding the impacts of seaweeds and their derived polysaccharides on the human microbiome and the profound need for more in-depth investigations into this topic. Animal experiments and in vitro colonic-simulating trials investigating the effects of seaweed ingestion on human gut microbiota are discussed.

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“…phycobiliproteins) are highly abundant in microalgae (Sonani et al 2016). Among them, phycocyanin and phycoerythrin are currently the main molecules from Spirulina platensis to be commercialized for many different purposes, including natural dyes and nutraceutics with anti-inflammatory, neuroprotective and anticancer properties (Jiang et al 2017) (Table 1).…”

Section: Microalgae As Natural Source Of Nutrients and Bio-active Commentioning

confidence: 99%

Potential of Microalgae Biomass for the Sustainable Production of Bio-commodities

Perin

Morosinotto

2019

Progress in Botany

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Human activities are causing major negative environmental impacts and the development of sustainable processes for production of commodities is a major urgency. Plants biomass represents a valuable alternative to produce energy and materials but exploiting present crops for commodities production would however require massive resources (i.e. land, water and nutrients), raising serious sustainability concerns. In addition to efforts to improve plants land and resources use efficiency, it is thus fundamental to look for alternative sources of biomass to complement crops. Microalgae are unicellular photosynthetic organisms that show a huge, yet untapped, potential in this context. Microalgae metabolism is powered by photosynthesis and thus uses sunlight, a renewable energy source and the exploitation of microalgae-based products has the potential to provide a beneficial environmental impact. These microorganisms have the ability to synthesise a wide spectrum of bioactive compounds, with many different potential applications (e.g. nutraceutics/pharmaceutics and biofuels). Several, still unresolved, challenges are however present such as the lack of cost-effective cultivation platforms and biomass-harvesting technologies. Moreover, the natural metabolic plasticity of microalgae is not optimized for a production at scale and low biomass productivity and product yields affect competitiveness. Tuning microalgae metabolism to maximize productivity thus represents an unavoidable challenge to reach the theoretical potential of such organisms.

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Phycocyanin: A Potential Drug for Cancer Treatment

Cited by 170 publications

References 135 publications

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Potential Use of Marine Seaweeds as Prebiotics: A Review

Potential of Microalgae Biomass for the Sustainable Production of Bio-commodities

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