Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT

Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands

“…For compound 6, we only observed an improved resolution of the spectra. Yet, for compounds 4 and 5, at 233 K, a new signal appeared in the 31 P NMR spectra at δ = 13.30 ppm (Figure 3) whose pattern is consistent with an [Ag 2 (NN) 2 (μdppe) 2 ] 2+ type complex. The doublet of multiplets observed (better resolved in B) can result from a distribution of isotopologues 19 ( 109 Ag-109 Ag, 109 Ag-107 Ag, and 107 Ag-107 Ag) close to 1:2:1, as the isotopic ratio for the two spin isotopes 109 Ag and 107 Ag (natural abundance 51.8 and 48.2%, respectively) is close to 1:1.…”

“…These results are in agreement with values reported in the literature. 17,18 In the case of compounds 1−3, the 31 ). In all cases, the coupling constants are in accordance with an AgN 2 P coordination environment for compounds 1−3, which are in perfect agreement with their solid-state structures (see single-crystal X-ray discussion).…”

“…Compound 7 was synthesized in dichloromethane at room temperature with silver trifluoromethanesulfonate and dppe 1:2. All new compounds were isolated by slow diffusion recrystallization in very good to excellent yields and fully analyzed by 1 H, 13 C{ 1 H}, 31 P{ 1 H}-NMR, FTIR, and UV−vis spectroscopies and mass spectrometry (see SI). Elemental analyses confirmed the stoichiometry and purity of all compounds.…”

“…Chemical shifts (δ) are reported in parts per million (ppm) referenced to tetramethylsilane (δ 0.00 ppm) using the residual proton solvent peaks as internal standards. 31 P{ 1 H} NMR chemical shifts were reported downfield from external standard 85% H 3 PO 4 . The multiplicity of the peaks is abbreviated as follows: s (singlet), d (doublet), t (triplet), m (multiplet), comp (complex), br (broad).…”

“…Characterization of compounds 1−7 (HR-MS, UV−vis, and NMR spectra); crystallographic data and structural details for X-ray data for 1, 2, 3, and 4; stability studies in 100% DMSO-d 6 performed by 1 H and 31…”