Transcriptome analysis of flavonoid biosynthesis in safflower flowers grown under different light intensities

Ren, Chaoxiang; Wang, Jie; Xian, Bin; Tang, Xiaohui; Liu, Xuyun; Hu, Xueli; Hu, Zunhong; Wu, Yingliang; Chen, Cuiping; Wu, Qinghua; Jiang, Chen; Pei, Jin

doi:10.7717/peerj.8671

Cited by 22 publications

(14 citation statements)

References 36 publications

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“…Safflower is an extract of Crocus sativus L. and is commonly used in the treatment of CVD. Clinical studies have shown that safflower has antioxidant and antiarrhythmic effects, as well as protective effects on damaged myocardium [ 152 – 154 ]. Thus, safflower is an antioxidant with potential for the prevention and treatment of heart failure.…”

Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.

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Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Supernatant was assayed for measurements of the total anthocyanidin by using an ultraviolet-visible spectrophotometer (UV-6000PC, Shanghai Metash, Shanghai, China) at 530 nm. A colorimetric method was used to analyze the total flavonoid content as described by Ren et al [ 25 ]. Rutin (Chengdu Herbpurify Co., Ltd., Chengdu, China) solution was used as standard.…”

Section: Methodsmentioning

confidence: 99%

Transcriptome and Metabolome Reveal Salt-Stress Responses of Leaf Tissues from Dendrobium officinale

Zhang

Zeng

et al. 2021

Biomolecules

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Dendrobium officinale Kimura et Migo is a precious traditional Chinese medicine. Despite D. officinale displaying a good salt-tolerance level, the yield and growth of D. officinale were impaired drastically by the increasing soil secondary salinization. The molecular mechanisms of D. officinale plants’ adaptation to salt stress are not well documented. Therefore, in the present study, D. officinale plants were treated with 250 mM NaCl. Transcriptome analysis showed that salt stress significantly altered various metabolic pathways, including phenylalanine metabolism, flavonoid biosynthesis, and α-linolenic acid metabolism, and significantly upregulated the mRNA expression levels of DoAOC, DoAOS, DoLOX2S, DoMFP, and DoOPR involved in the jasmonic acid (JA) biosynthesis pathway, as well as rutin synthesis genes involved in the flavonoid synthesis pathway. In addition, metabolomics analysis showed that salt stress induced the accumulation of some compounds in D. officinale leaves, especially flavonoids, sugars, and alkaloids, which may play an important role in salt-stress responses of leaf tissues from D. officinale. Moreover, salt stress could trigger JA biosynthesis, and JA may act as a signal molecule that promotes flavonoid biosynthesis in D. officinale leaves. To sum up, D. officinale plants adapted to salt stress by enhancing the biosynthesis of secondary metabolites.

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“…Previous studies have shown that the accumulation of flavonoids in plants is generally upregulated with exposure to light, while shading downregulates the accumulation [40][41][42]. Interestingly, the production of different flavonoids is induced by different light ranges, intensities, and periods [43,44]. Controlled exposure to light or shading treatments has been frequently applied in the cultivation of tea and wine grapes to obtain the ideal levels of bitter-tasting and astringent flavonoids in the final products.…”

Section: Molecular Basis Of Reducing the Bitter Taste Of P Amarus Bam...mentioning

confidence: 99%

Integrated Metabolomic and Transcriptomic Analysis Reveals the Effect of Artificial Shading on Reducing the Bitter Taste of Bamboo Shoots

Huang

Xun

et al. 2022

Horticulturae

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Bamboo shoot is a delicious and nutritious forest vegetable. It has been found that bamboo shoots collected from low-light environments have a less bitter taste. The molecular mechanism of light in the regulation of bitter substance accumulation in bamboo shoots is still unclear. In this study, we applied a shading treatment to Pleioblastus amarus bamboo shoots in the preharvesting period. The reduction in the bitterness intensity was confirmed by a sensory test. An integrated metabolomic and transcriptomic analysis was performed on P. amarus bamboo shoots grown under shading treatment and normal growing conditions, and 56 differentially accumulated metabolites and 178 differentially expressed genes were identified. The results showed that the contents of a series of phenolic acids related to the tyrosine metabolism pathway were downregulated under shading treatment, revealing that shading decreased the accumulation of phenolic acids and further mediated the resulting bitter taste of the bamboo shoots. This work will be helpful for understanding the regulatory mechanisms governing the bitter tasting substances in bamboo shoots grown under a shading treatment and provides a reference for the use of shading treatment in cultivation practices to improve the taste of bamboo shoots.

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Transcriptome analysis of flavonoid biosynthesis in safflower flowers grown under different light intensities

Cited by 22 publications

References 36 publications

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Transcriptome and Metabolome Reveal Salt-Stress Responses of Leaf Tissues from Dendrobium officinale

Integrated Metabolomic and Transcriptomic Analysis Reveals the Effect of Artificial Shading on Reducing the Bitter Taste of Bamboo Shoots

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