Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways

Scisciani, C.; Vossio, Stefania; Guerrieri, Francesca; Schinzari, Valeria; Iaco, Rossana De; Meo, Paolo D’Onorio De; Cervello, Melchiorre; Montalto, Giuseppe; Pollicino, Teresa; Raimondo, Giovanni; Levrero, Massimo; Pediconi, Natalia

doi:10.1016/j.jhep.2011.11.017

Cited by 125 publications

(87 citation statements)

References 40 publications

(57 reference statements)

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“…The expression of miR-224 was significantly higher in the HCC cell lines than in normal hepatic tissues and the fibroblast cell line WI-38 (P = 0.0150) ( Figure 3B). These findings strongly suggested that miR-224 expression was highly expressed in HCC, as shown in previous reports [54][55][56][57][58].…”

Section: Confirmation Of Higher Mir-224 Expression In Hcc Tissues Andsupporting

confidence: 89%

“…Regarding the molecular function of miR-224, the expression of miR-224 is primarily regulated through cut-off value: 20*** *miR-224/cel-miR-39 ratio, ** mAU/ml, *** ng/ml signaling pathways, such as the NF-κB inflammatory signaling pathway and TGF-β signaling pathways [56,61]. This molecule is also reported as a master regulator of cell cycle progression and its overexpression results in G1/S checkpoint release followed by accelerated cell growth [62].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, 27 miRNAs, insufficient for clinical application and reported in only one article, were excluded. After a series of exclusion criteria were applied, we systematically selected four candidate miRNAs: miR-151 [48][49], miR-155 [50][51], miR-191 [52][53], and miR-224 [54][55][56][57][58].…”

Section: Selection Of Candidate Mirnas From the Ncbi Databasementioning

confidence: 99%

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Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Okajima¹,

Komatsu²,

Ichikawa³

et al. 2016

European Journal of Cancer

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Section: Confirmation Of Higher Mir-224 Expression In Hcc Tissues Andsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Okajima¹,

Komatsu²,

Ichikawa³

et al. 2016

European Journal of Cancer

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“…More recently, a study demonstrated that miR-224 downregulation was frequently found in metastatic PCa tissues [23]. In contrast, several studies have demonstrated that miR-224 is highly expressed in various cancers, such as hepatocellular carcinoma [24][25][26][27][28], pancreatic ductal carcinoma [29], colorectal cancer [25,30] and renal cell carcinoma [31]. Interestingly, overexpression of miR-224 in hepatocellular carcinoma contributes to the regulation of cell migration and invasion [24,28,32], contradicting the data from our study of PCa.…”

Section: Discussionmentioning

confidence: 99%

Tumour‐suppressive microRNA‐224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer

et al. 2014

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Edited by Tamas DalmayKeywords: miR-224 TPD52 Prostate cancer microRNA Tumour suppressor a b s t r a c t Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. Here, we found that restoration of miR-224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR-224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR-224 expression. We conclude that loss of tumour-suppressive miR-224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52.

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“…Wang et al have shown that miR-224 is coordinately up-regulated with neighboring miR-452 and genes at Xq28 in HCC tumors (94). Scisciani et al identified that p65/NF-κB (nuclear factor kappa-lightchain-enhancer of activated B cells) is a direct transcriptional regulator of miR-224 expression and links miR-224 up-regulation with the activation of the LPS, LTα, and TNFα inflammatory pathways, as well as cell migration/invasion in HCC (95). The negative regulation of miR-224 on NF-κB or other cytokines expression may directly block the antitumoral ability of the host, causing the involved pathways to shift to abnormal status and finally facilitate HCC development.…”

Section: Mir-224mentioning

confidence: 99%

Role of microRNAs in hepatocellular carcinoma

Liu¹,

Li²,

et al. 2015

Front Biosci

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Context: MicroRNAs (miRNAs) are small, noncoding RNAs that play an important role in posttranscriptional gene regulation and function as negative gene regulators. They are an abundant class of RNA, each of which can control hundreds of gene targets and regulate diverse biological processes such as hematopoiesis, organogenesis, apoptosis and cell proliferation. Aberrant miRNA expression contributes to tumorigenesis and cancer progression. Evidence Acquisition: In this study we provided a summarized review of the most important new data available on hepatocellular carcinoma (HCC)-associated miRNAs. The data were collected through searching the related keywords and were categorized and summarized in different sections. Results: Researchers have reported that miRNAs can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. During the past two decades, numerous studies have shown that miRNAs play an essential role in inhibiting HCC via several different pathways. Deregulated miRNAs may contribute to carcinogenesis, indicating that miRNAs can act as tumor suppressors and oncogenes. Conclusions: In this mini review, we highlight current findings and discuss recent work to determine the contribution of miRNA expression to the maintenance and growth of HCC, thereby providing a significant source of hope that miRNAs could serve as therapeutic targets.

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Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways

Cited by 125 publications

References 40 publications

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Tumour‐suppressive microRNA‐224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer

Role of microRNAs in hepatocellular carcinoma

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