2004
DOI: 10.1016/j.plefa.2003.04.003
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Transcriptional regulation of genes for enzymes of the prostaglandin biosynthetic pathway

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Cited by 30 publications
(24 citation statements)
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“…The effect of TNF-α is partially mediated by PLA 2 and COX-2, which promote a shift towards a proinflammatory lipid profile (e.g., leukotriene B 4 and PGE 2 ) to further perpetuate inflammatory responses [6,43]. The induction of PLA 2 and COX-2 can be mediated through NF-κB and MAPK signaling in response to TNF-α.…”
Section: Discussionmentioning
confidence: 99%
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“…The effect of TNF-α is partially mediated by PLA 2 and COX-2, which promote a shift towards a proinflammatory lipid profile (e.g., leukotriene B 4 and PGE 2 ) to further perpetuate inflammatory responses [6,43]. The induction of PLA 2 and COX-2 can be mediated through NF-κB and MAPK signaling in response to TNF-α.…”
Section: Discussionmentioning
confidence: 99%
“…The substrate AA is then converted into prostaglandins and leukotrienes by the cyclooxygenase (e.g., via the COX-1 and COX-2) and lipoxygenase pathways, respectively [5]. The induction of PLA 2 and COX-2 is highly regulated through mitogen-activated protein kinases (MAPKs), nuclear factor-kappa B (NF-κB), and other pathways [6], and can be stimulated by cytokines and trauma [5]. In turn, prostaglandins, especially prostaglandin E 2 (PGE 2 ), can modulate inflammatory responses by regulating cytokine production and leukocyte activation [1,7].…”
Section: Introductionmentioning
confidence: 99%
“…Down-regulation of GILZ in the decidua may also play a role in the parturition cascade through its regulation of nuclear factor kappa B (NF-kB) (Lindstrom & Bennett 2004). In vitro, GILZ co-immunoprecipitates with p65, which would inhibit transactivation of NF-kB (Lindstrom & Bennett 2004).…”
Section: Implantation-site Transcription Factors 565mentioning
confidence: 99%
“…In vitro, GILZ co-immunoprecipitates with p65, which would inhibit transactivation of NF-kB (Lindstrom & Bennett 2004). Release of GILZ's inhibition (by downregulation of GILZ) of NF-kB may play an important role in the parturition cascade.…”
Section: Implantation-site Transcription Factors 565mentioning
confidence: 99%
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