Transcriptional mechanisms regulating Ca2+ homeostasis

Ritchie, Michael; Zhou, Yandong; Soboloff, Jonathan

doi:10.1016/j.ceca.2010.10.001

Cited by 33 publications

(24 citation statements)

References 142 publications

(155 reference statements)

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“…Furthermore, Ca 2ϩ oscillations regulate SERCA2 expression in astrocytes after growth factor receptor stimulation (65) and in human lens epithelial cells (66), although there is no evidence of NFAT binding to the SERCA2 promoter. In addition, MAPK-and PKC-dependent induction of Erg1 results in down-regulation of the SERCA2 gene, although, again, the effect is probably indirect because no functional Erg1-binding sites are found in the SERCA2 promoter (10,67,68).…”

Section: Regulation Of Sodium/calcium Exchangers and Calcium Pumpsmentioning

confidence: 99%

“…Of the different control mechanisms, here we will review those that control Ca 2ϩ homeostasis at the transcriptional level and that are directly regulated by Ca 2ϩ . A review of the transcriptional control of calcium homeostasis, with particular emphasis on the roles of members of the Egr (early growth response) family of zinc finger immediate-early transcription factors and the closely related protein WT1 (Wilms tumor suppressor 1), has been published recently (10).…”

Section: Intracellular Free Camentioning

confidence: 99%

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Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Naranjo

Mellström

2012

Journal of Biological Chemistry

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Intracellular free Ca2؉ ions regulate many cellular functions, and in turn, the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca 2؉ . Here, we review recent work on Ca 2؉ -dependent mechanisms and effectors that regulate the transcription of genes encoding proteins involved in the maintenance of the homeostasis of Ca 2؉ in the cell.Control of intracellular free calcium is a delicate balance between mechanisms that provide the ion, including extracellular membrane calcium channels (voltage-, ligand-, and storeoperated types) and intracellular calcium release channels (ryanodine (RyR) 2 and inositol 1,4,5-trisphosphate (IP 3 R) receptors), and mechanisms that clear the ion from the cytosol, including calcium pumps and exchangers that are localized both in extra-and intracellular membranes (1, 2). Consolidated evidence, as well as recent evidence, indicates that this group of proteins, with the mission to keep tight control of free Ca 2ϩ concentration, is in turn subjected to regulation by several mechanisms controlled by changes in free Ca 2ϩ concentration. In some cases, these self-regulatory processes involve parallel compensatory changes in several Ca 2ϩ regulatory proteins so that increases or decreases in intracellular stores and cytosolic Ca 2ϩ levels slowly adjust the concentrations of key signaling pathway components (3). In other cases, components of the homeostasis machinery are coordinately modified to respond to chronic pathological conditions as in end stages of heart failure (4, 5) or in neurodegenerative processes. Thus, in Huntington disease striatal neurons accumulate changes in the expression of most, if not all, genes related to Ca 2ϩ homeostasis (6). Also, in Alzheimer disease (AD), changes in the expression of RyRs and STIM (stromal interacting molecule) have been observed in the hippocampus of presymptomatic AD mouse models (7) and post-mortem human brain samples (8) and in B lymphocytes from patients with familial AD mutations in the presenilin-1 gene (9), respectively. Of the different control mechanisms, here we will review those that control Ca 2ϩ homeostasis at the transcriptional level and that are directly regulated by Ca 2ϩ . A review of the transcriptional control of calcium homeostasis, with particular emphasis on the roles of members of the Egr (early growth response) family of zinc finger immediate-early transcription factors and the closely related protein WT1 (Wilms tumor suppressor 1), has been published recently (10).Control of the activity of specific transcriptional networks by Ca 2ϩ is regulated by cytosolic and nuclear mechanisms that decode the calcium signal specificity in terms of frequency and spatial properties. Thus, the Ca 2ϩ entry site (synaptic versus extrasynaptic) or its intracellular source (mitochondria, endoplasmic reticulum (ER), or Golgi apparatus) makes the Ca 2ϩ ions face different microdomains that are composed of specific sets of proteins and determines the biological outcome of the Ca 2ϩ signal by inducing t...

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Section: Regulation Of Sodium/calcium Exchangers and Calcium Pumpsmentioning

confidence: 99%

Section: Intracellular Free Camentioning

confidence: 99%

Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Naranjo

Mellström

2012

Journal of Biological Chemistry

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“…Furthermore, Egr-1 deficiency is very sensitive to the perturbation of intracellular calcium homeostasis, because only treatment of Egr-1 knockdown cells with thapsigargin, which inhibits SERCA leading to calcium depletion in ER, causes further increases in ER stress and cell death. Altered calcium regulation has been found in Egr1 −/− cardiomyocytes through downregulation of major proteins involved in control of calcium homeostasis [35,36]. Thus, we speculate that attenuation of ER stress by Egr-1 in β-cells may mediate through remodeling of calcium homeostasis.…”

Section: Discussionmentioning

confidence: 96%

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis

Cheong¹,

Kuo²,

Cheng³

et al. 2015

J Mol Med

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“…Існує [92]. Беру-чи до уваги, що зміна експресії Са 2+ -помпи ПМ відбувається за багатьох захворювань (діабет, пухлини, остеопороз) дослідження регуляції транскрипції гена цієї помпи потребує більшої уваги.…”

Section: +unclassified

Mg(2+),ATP-dependent plasma membrane calcium pump of smooth muscle cells. ІІ. Regulation of activity

Veklich¹

2015

Ukr.Biochem.J.

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Transcriptional mechanisms regulating Ca2+ homeostasis

Cited by 33 publications

References 142 publications

Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis

Mg(2+),ATP-dependent plasma membrane calcium pump of smooth muscle cells. ІІ. Regulation of activity

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