Transcriptional coactivator PGC-1α contributes to decidualization by forming a histone-modifying complex with C/EBPβ and p300

Takagi, Hajime; Tamura, Isao; Fujimura, Taishi; Doi-Tanaka, Yumiko; Shirafuta, Yuichiro; Mihara, Yumiko; Maekawa, Ryo; Tanaka, Toshiaki; Sato, Shun; Tamura, Hiroshi; Sugino, Norihiro

doi:10.1016/j.jbc.2022.101874

Cited by 10 publications

(9 citation statements)

References 84 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This increase of H3K27ac is regulated by the recruitment of C/EBPβ and WT1 because the knockdown of these transcription factors decreased the H3K27ac level [26]. In general, histone modifications are induced by the recruitment of pioneer transcription factors, which are responsible for the initiation of the epigenetic changes [44][45][46][47]. These factors recruit the cofactors that have histone acetyltransferase (HAT) activities, such as p300, to induce H3K27ac [48,49].…”

Section: Mechanism Of Glucose Uptake During Decidualizationmentioning

confidence: 99%

Glucose and lipid metabolisms in human endometrial stromal cells during decidualization

et al. 2023

View full text Add to dashboard Cite

Decidualization is a process of differentiation of human endometrial stromal cells (hESCs) accompanied by dramatic changes in cellular functions. This process is critical for embryo implantation and the establishment of pregnancy. Impairment of decidualization of hESCs leads to implantation failure, miscarriage, and unexplained infertility. The present review focuses on the metabolic changes in hESCs during decidualization. One of the changes taking place is in the glucose metabolism. Glucose uptake increases during decidualization because glucose is essential for the decidualization of hESCs. In hESCs, GLUT1 is highly expressed and involved in the increase of glucose uptake during decidualization. The up-regulation of GLUT1 is mediated by an epigenetic mechanism, which is regulated by CCAAT enhancer-binding protein β (C/EBPβ) and Wilms tumor 1 (WT1). Another metabolic change is in the lipid metabolism. Lipid accumulation in hESCs increases during decidualization. This increase is mediated by very low-density lipoprotein receptor (VLDLR). The up-regulation of VLDLR is regulated by WT1. In contrast to glucose, lipid is not essential for decidualization of hESCs. Endometrial cells have been implicated as important sources of nutrition for the embryo. hESCs may increase glucose and lipid storage so that they can supply them to the embryo during the implantation process. Taken together, decidualization is the process accompanied by metabolic changes, which may be associated with successful implantation.

show abstract

Section: Mechanism Of Glucose Uptake During Decidualizationmentioning

confidence: 99%

Glucose and lipid metabolisms in human endometrial stromal cells during decidualization

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Histofine Simple Stain MAX‐PO (R) (Nichirei Co Ltd) was used following the manufacturer's protocol as previously reported. 25 , 26 , 27 In brief, the sections were incubated with anti‐FOXO1 (Abcam plc), anti‐WT1 antibodies (Abcam), and anti‐C/EBPβ (Santa Cruz Biotechnology, Inc) at 4°C overnight followed by incubation with the secondary antibodies. Negative control sections were incubated with normal rabbit serum.…”

Section: Methodsmentioning

confidence: 99%

High incidence of decidualization failure in infertile women

Tamura,

Doi‐Tanaka,

Takasaki

et al. 2024

Reprod Medicine & Biology

Self Cite

View full text Add to dashboard Cite

PurposeDecidualization is an important event for embryo implantation and successful pregnancy. Impaired decidualization leads to implantation failure and miscarriage. However, it is unclear how often decidualization failure occurs in infertile women. By analyzing the endometrium at late‐secretory phase, we investigated the incidence and pathogenesis of decidualization failure among infertile women.MethodsEndometrial dating was performed on the endometria obtained in the late‐secretory phase from 33 infertile women. Endometrial dating of more than 2 days delay was taken as an indication of decidualization failure. The expression of essential transcription factors for decidualization (FOXO1, WT1, and C/EBPβ) was examined by immunohistochemistry.ResultsAmong 32 cases, 20 cases (62.5%) showed decidualization failure. These patients tended to have a history of more frequent miscarriages than those without decidualization failure. The percentage of cells that immunostained positive for the expression of three transcription factors was significantly lower in the patients with decidualization failure than in those without decidualization failure. Serum progesterone levels measured in the mid‐ and late‐secretory phase were not significantly different between the cases with and without decidualization failure.ConclusionsThe incidence of decidualization failure is high in infertile women.

show abstract

“…continuously evolve during the secretory and early pregnancy states. 4,5 In addition to driving a transcriptional program that renders stromal cells responsive to hormonally regulated transcription factors such as PR, COUP-TF, and FOXO1, a key role of the decidua is to prevent rejection of the semi-allogenic fetus by conferring a state of immunotolerance. An immunotolerant maternal-fetal interface is accomplished in part by the secretion of cytokines that drive uterine natural killer cell recruitment.…”

Section: Introductionmentioning

confidence: 99%

“…Morphologically, the stromal cells transform from fibroblast‐like cells into cuboidal‐like cells due to collagen reorganization (Figure 1). Genetically, the cells undergo shifts in chromatin remodeling and subsequent gene expression changes that continuously evolve during the secretory and early pregnancy states 4,5 . In addition to driving a transcriptional program that renders stromal cells responsive to hormonally regulated transcription factors such as PR, COUP‐TF, and FOXO1, a key role of the decidua is to prevent rejection of the semi‐allogenic fetus by conferring a state of immunotolerance.…”

Section: Introductionmentioning

confidence: 99%

Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface

Parks,

Geng,

Monsivais

2023

American J Rep Immunol

View full text Add to dashboard Cite

The endometrium is a unique and highly regenerative tissue with crucial roles during the reproductive lifespan of a woman. As the first site of contact between mother and embryo, the endometrium, and its critical processes of decidualization and immune cell recruitment, play a leading role in the establishment of pregnancy, embryonic development, and reproductive capacity. These integral processes are achieved by the concerted actions of steroid hormones and a myriad of growth factor signaling pathways. This review focuses on the roles of the transforming growth factor β (TGFβ) pathway in the endometrium during the earliest stages of pregnancy through the lens of immune cell regulation and function. We discuss how key ligands in the TGFβ family signal through downstream SMAD transcription factors and ultimately remodel the endometrium into a state suitable for embryo implantation and development. We also focus on the key roles of the TGFβ signaling pathway in recruiting uterine natural killer cells and their collective remodeling of the decidua and spiral arteries. By providing key details about immune cell populations and TGFβ signaling within the endometrium, it is our goal to shed light on the intricate remodeling that is required to achieve a successful pregnancy.

show abstract

Transcriptional coactivator PGC-1α contributes to decidualization by forming a histone-modifying complex with C/EBPβ and p300

Cited by 10 publications

References 84 publications

Glucose and lipid metabolisms in human endometrial stromal cells during decidualization

Glucose and lipid metabolisms in human endometrial stromal cells during decidualization

High incidence of decidualization failure in infertile women

Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface

Contact Info

Product

Resources

About