Transcriptional Changes in Candida albicans Genes by Both Farnesol and High Cell Density at an Early Stage of Morphogenesis in N-acetyl-D-glucosamine Medium

Cho, Tamaki; Aoyama, Toshihiro; Toyoda, Mika; Nakayama, Hironobu; Chibana, Hiroji; Kaminishi, Hidenori

doi:10.3314/jjmm.48.159

Cited by 18 publications

(14 citation statements)

References 44 publications

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“…In contrast, farnesol has no effect on biofilm maturation, only cells in mature biofilms become sensitive to farnesol again (Ramage, Saville, et al, 2002). Besides its effect on yeast-to-hyphae and hyphae-to-yeast transition, farnesol affects genes involved in drug resistance, cell wall maintenance, phagocytic response, surface hydrophobicity, iron transport, and a range of Hsps (Cao et al, 2005;Cho et al, 2007;Enjalbert & Whiteway, 2005;Uppuluri, Mekala, & Chaffin, 2007).…”

Section: The Quorum Sensing Molecule Farnesol and Cellular Signalingmentioning

confidence: 90%

Candida Survival Strategies

Polke

Hube

Jacobsen

2015

Advances in Applied Microbiology

150

101

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Section: The Quorum Sensing Molecule Farnesol and Cellular Signalingmentioning

confidence: 90%

Candida Survival Strategies

Polke

Hube

Jacobsen

2015

Advances in Applied Microbiology

150

101

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“…4). There are several reports showing an increase in mRNA and protein expression in C. albicans in response to farnesol (Cho et al, 2007;Shirtliff et al, 2009). There are several reports showing an increase in mRNA and protein expression in C. albicans in response to farnesol (Cho et al, 2007;Shirtliff et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, filamentous cells present a much lower metabolic activity when compared to cells growing as yeast (Han et al, 2012). Indeed, Cho et al (2007) analysed the global transcription profile of C. albicans in response to farnesol in Fig. 5).…”

Section: Discussionmentioning

confidence: 99%

The metabolic response ofCandida albicansto farnesol under hyphae-inducing conditions

2012

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Farnesol is a quorum-sensing molecule (QSM) produced, and sensed, by the polymorphic fungus, Candida albicans. This cell-to-cell communication molecule is known to suppress the hyphal formation of C. albicans at high cell density. Despite many studies investigating the signalling mechanisms by which QSMs influence the morphogenesis of C. albicans, the downstream metabolic effect of these signalling pathways in response to farnesol-mediated morphogenesis remains obscure. Here, we have used metabolomics to investigate the metabolic response of C. albicans upon exposure to farnesol under hyphae-inducing conditions. We have found a general up-regulation of central carbon metabolic pathways when hyphal formation was suppressed by farnesol evidenced by a considerably larger number of central carbon metabolic intermediates detected under this condition at an overall lower intracellular level. By combining the metabolic profiles from farnesol-exposed cells with previous metabolomics data for C. albicans undergoing morphogenesis, we have identified several metabolic pathways that are likely to be associated with the morphogenetic process of C. albicans, as well as metabolic pathways such as those involved in lipid metabolism that appeared to be specifically affected by farnesol. Therefore, our results provide important new insights into the metabolic role of farnesol in C. albicans metabolism.

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“…For example, HGC1 is necessary for hyphal development (69) and the microarray data show that FA exposure downregulates HGC1 . Another group examined the expression profile of C. albicans genes in the early yeast-to-hyphae transition period when grown in nonenriched media (8). They found that many genes affected by FA are also affected by high cell density, which would be expected from a quorum-sensing molecule.…”

Section: Farnesol Signalingmentioning

confidence: 99%

Lipid Signaling in Pathogenic Fungi

Rhome

Poeta

2009

Annu. Rev. Microbiol.

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Lipid signaling in pathogenic fungi has been studied to determine the role of these pathways in fungal biology and human infections. Owing to their unique nature, they may represent targets for future antifungal treatments. Farnesol signaling was characterized as a quorum-sensing molecule, with exposure inhibiting filamentation. Research has shown involvement in both the Ras1-adenylate cyclase and MAP kinase pathways. In species of Aspergillus, farnesol exposure induces apoptosis-like changes and alterations in ergosterol synthesis. Eicosanoid production has been characterized in several pathogenic fungi, utilizing host lipids in some cases. The role in virulence is not known yet, but it may involve modulation of host lipids. Sphingolipid signaling pathways seem to center around the production of diacylglycerol in the formation of inositol phosphorylceramide. Diacylglycerol activates both melanin production through laccase and transcription of antiphagocytic protein, both of which are involved in virulence.

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Transcriptional Changes in Candida albicans Genes by Both Farnesol and High Cell Density at an Early Stage of Morphogenesis in N-acetyl-D-glucosamine Medium

Cited by 18 publications

References 44 publications

Candida Survival Strategies

Candida Survival Strategies

The metabolic response ofCandida albicansto farnesol under hyphae-inducing conditions

Lipid Signaling in Pathogenic Fungi

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