Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction

Chen, Wenyang; Guo, Xing-Dao; Jin, Zhen; Li, Runan; Li-xia, Shen; Li, Wei; Cai, Wangting; Zhang, Guirong

doi:10.1080/19396368.2019.1678694

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…In this context, sleep deprivation (deprived of restful REM sleep using the flowerpot technique) was associated with a significant unbalance in histone activity as well as oxidative stress and ongoing inflammation in rat hippocampus [162]. Moreover, differentially expressed genes involved in inflammatory pathways and declined fertility were detected in male rats exposed to chronic sleep restriction, which was not related to DNA methylation mechanisms [163]. Also, sleep-disordered breathing (a common disorder inducing oxidative stress and inflammation) was associated with epigenetic age acceleration among individuals at high cardiovascular risk [164].…”

Section: Sleep Patternsmentioning

confidence: 99%

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

et al. 2020

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Aim and objective Emerging translational evidence suggests that epigenetic alterations (DNA methylation, miRNA expression, and histone modifications) occur after external stimuli and may contribute to exacerbated inflammation and the risk of suffering several diseases including diabetes, cardiovascular diseases, cancer, and neurological disorders. This review summarizes the current knowledge about the harmful effects of high-fat/high-sugar diets, micronutrient deficiencies (folate, manganese, and carotenoids), obesity and associated complications, bacterial/viral infections, smoking, excessive alcohol consumption, sleep deprivation, chronic stress, air pollution, and chemical exposure on inflammation through epigenetic mechanisms. Additionally, the epigenetic phenomena underlying the anti-inflammatory potential of caloric restriction, n-3 PUFA, Mediterranean diet, vitamin D, zinc, polyphenols (i.e., resveratrol, gallic acid, epicatechin, luteolin, curcumin), and the role of systematic exercise are discussed. Methods Original and review articles encompassing epigenetics and inflammation were screened from major databases (including PubMed, Medline, Science Direct, Scopus, etc.) and analyzed for the writing of the review paper. Conclusion Although caution should be exercised, research on epigenetic mechanisms is contributing to understand pathological processes involving inflammatory responses, the prediction of disease risk based on the epigenotype, as well as the putative design of therapeutic interventions targeting the epigenome.

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Section: Sleep Patternsmentioning

confidence: 99%

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

et al. 2020

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“…Chen et al. observed that SR for 35 days decreased sperm concentration, viability, and motility, while it increased sperm malformation ( 77 ). Alvarenga et al.…”

Section: Sleep Duration and Male Fertilitymentioning

confidence: 99%

“…For example, Chen et al. found that sleeping for 6 h/night for 35 days significantly decreased the testosterone concentration ( 77 ) and Alvarenga et al. observed that SD for 96 h significantly inhibited testosterone levels by 45% ( 78 ).…”

Section: Sleep Duration and Male Fertilitymentioning

confidence: 99%

“…reported that SD4 and SD7 significantly decreased testosterone release but increased corticosterone production ( 32 ). Although the mechanism has not been clarified ( 77 ), authors inferred that sleep deficiency increased cortisol and corticosterone levels by activating the hypothalamic–pituitary–adrenal (HPA) axis, the feedback of which inhibited the hypothalamus–pituitary–gonadal (HPG) axis to decrease testosterone secretion ( 30 , 32 ). In contrast, a preliminary cross-sectional study based on 92 healthy men found that insufficient sleep did not alter total/free testosterone levels ( 75 ), while the MARHCS trial found that sleep duration had no impact on reproductive hormones ( 72 ).…”

Section: Sleep Duration and Male Fertilitymentioning

confidence: 99%

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The potential impacts of circadian rhythm disturbances on male fertility

Bai

Jiang³

et al. 2022

Front. Endocrinol.

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A circadian rhythm is an internalized timing system that synchronizes the cellular, behavioral, and physiological processes of organisms to the Earth’s rotation. Because all physiological activities occur at a specific time, circadian rhythm disturbances can lead to various pathological disorders and diseases. Growing evidence has shown that the circadian clock is tightly connected to male fertility, and circadian perturbations contribute to infertility. The night shiftwork, insufficient sleep, and poor sleep quality are common causes of circadian disturbances, and many studies have reported that they impair sperm quality and increase the risk of male infertility. However, research on the impacts of light, body temperature, and circadian/circannual rhythms is relatively lacking, although some correlations have been demonstrated. Moreover, as the index of sperm quality was diverse and study designs were non-uniform, the conclusions were temporarily inconsistent and underlying mechanisms remain unclear. A better understanding of whether and how circadian disturbances regulate male fertility will be meaningful, as more scientific work schedules and rational lifestyles might help improve infertility.

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“…Pik3cb is highly expressed in obese individuals during pregnancy and can increase insulin sensitivity in offspring, which is beneficial for the metabolic health of offspring after weaning [ 69 ]. In addition, pik3cb showed low expression in the chronic sleep restriction group, and it was related to the prolactin (PRL) signaling pathway; the expression of pik3cb could be impacted by chronic sleep restriction to interrupt the Pi3k/Akt signaling pathways, further inhibiting spermatogenesis [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

Deng

Zhao

et al. 2023

IJMS

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The greater amberjack (Seriola dumerili) is a gonochoristic fish with no sexual dimorphism in appearance, making sex identification difficult. Piwi-interacting RNAs (piRNAs) function in transposon silencing and gametogenesis and are involved in various physiological processes, including sex development and differentiation. Exosomal piRNAs can be indicators for the determination of sex and physiological status. In this study, four piRNAs were differentially expressed in both serum exosomes and gonads between male and female greater amberjack. Three piRNAs (piR-dre-32793, piR-dre-5797, and piR-dre-73318) were significantly up-regulated and piR-dre-332 was significantly down-regulated in serum exosomes and gonads of male fish, compared to female fish, consistent with the serum exosomal results. According to the relative expression of four marker piRNAs derived from the serum exosomes of greater amberjack, the highest relative expression of piR-dre-32793, piR-dre-5797, and piR-dre-73318 in seven female fish and that of piR-dre-332 in seven male fish can be used as the standard for sex determination. The method of sex identification can ascertain the sex of greater amberjack by blood collection from the living body, without sacrificing fish. The four piRNAs did not show sex-inclined expression in the hypothalamus, pituitary, heart, liver, intestine, and muscle tissue. A piRNA–target interaction network involving 32 piRNA-mRNA pairs was generated. Sex-related target genes were enriched in sex-related pathways, including oocyte meiosis, transforming growth factor-beta signaling pathway, progesterone-mediated oocyte maturation, and gonadotropin releasing hormone signaling pathway. These results provide a basis for sex determination in greater amberjack and improve our understanding of the mechanisms underlying sex development and differentiation in the species.

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Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction

Cited by 14 publications

References 43 publications

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

The potential impacts of circadian rhythm disturbances on male fertility

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

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