Transcription and protein synthesis inhibitors influence long-term effects of acetyl-l-carnitine on non-associative learning in the leech

Learning processes in elementary nervous systems§

“…By applying a session of light stimuli every day, LT habituation was induced after 5-7 days; similarly, by applying every day a noxious stimulus, LT sensitization was induced. Protein synthesis inhibitors (cycloheximide) and mRNA blocking agents (such as actinomycin D) prevent LT facilitation of swimming induction without affect ST memory (Traina and Scuri, 2015). Therefore, even in this animal model, LT memory requires qualitative and quantitative gene expression and protein synthesis modifications.…”