Transcranial Photobiomodulation Therapy Ameliorates Perioperative Neurocognitive Disorder Through Modulation of Mitochondrial Function in Aged Mice

Zhang, Xiaojun; Wu, Wensi; Luo, Yuelian; Wang, Zhi

doi:10.1016/j.neuroscience.2021.12.033

Cited by 12 publications

(5 citation statements)

References 69 publications

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“…Similar to our previous experiments ( Zhang et al, 2021 ), to evaluate the difference between locomotor activity and anxiety, during the open field test, mice moved freely for 5 min in an open-field apparatus consisting of a black opaque plastic chamber (60 cm × 60 cm × 50 cm, ZH-OFT, Anhui Zhenghua Biological Instrument Equipment Co., Ltd., Anhui, China). The behaviors of mice were recorded and analyzed by a video tracking system (Smart v3.0.06, Panlab Harvard Apparatus, Barcelona, Spain).…”

Section: Methodsmentioning

confidence: 99%

Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

Zhang

Zheng

et al. 2022

Front. Neurosci.

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BackgroundProlonged exposure to general anesthesia (GA) results in long-lasting cognitive impairment, especially during critical stages of brain development. An exaggerated neuroinflammation induced by anesthesia is generally considered to be a key cause of cognitive impairment.Materials and methodsPostnatal day 7 (PND 7) mice were exposed to GA by isoflurane inhalation for 6 h or mock anesthesia. Disodium cromoglycate (DSCG) was intraperitoneally injected daily for 2 weeks, beginning from 30 min before anesthesia. The post-anesthesia evaluation included behavioral tests, toluidine blue staining, immunofluorescence and western blot.ResultsOur results demonstrated the long-term cognition were impaired after 6 h GA exposure in neonatal mice. DSCG treatment ameliorated early mast cells (MCs) degranulation and mast cell tryptase (MCT) expression, which helps to attenuate subsequent neuroinflammation, activation of microglia and astrocytes, and damage to oligodendrocytes and synapses to improve cognitive impairment.ConclusionDisodium cromoglycate could effectively improve long-term cognitive impairment after GA exposure in neonatal mice.

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Section: Methodsmentioning

confidence: 99%

Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

Zhang

Zheng

et al. 2022

Front. Neurosci.

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“…Additionally, models that focus on the dopaminergic and serotonergic systems, like quinpirole‐induced compulsive checking in rats and meta‐Chlorophenylpiperazine (mCPP)‐induced directional persistence, provide important insights into the neurochemical aspects of OCD (Szechtman et al., 1998; Tsaltas et al., 2005). Similarly, several models have been employed to investigate t‐PBM's effects on mitochondria, synapses, neurons, signaling, and inflammatory pathways (Dos Santos Cardoso et al., 2021; Salehpour et al., 2018; Zhang et al., 2022). These animal models might be instrumental in investigating the direct and indirect effects of t‐PBM in OCD, including anti‐inflammatory properties.…”

Section: Future Directions and Perspectivesmentioning

confidence: 99%

“…several models have been employed to investigate t-PBM's effects on mitochondria, synapses, neurons, signaling, and inflammatory pathways (Dos Santos Cardoso et al, 2021;Salehpour et al, 2018;Zhang et al, 2022). These animal models might be instrumental in investigating the direct and indirect effects of t-PBM in OCD, including anti-inflammatory properties.…”

Section: Future D Irec Ti On S and Per S Pec Tive Smentioning

confidence: 99%

Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

Coelho,

Salvi,

Vieira

et al. 2024

J of Neuroscience Research

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Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects about 2%–3% of the global population. Despite the availability of several treatments, many patients with OCD do not respond adequately, highlighting the need for new therapeutic approaches. Recent studies have associated various inflammatory processes with the pathogenesis of OCD, including alterations in peripheral immune cells, alterations in cytokine levels, and neuroinflammation. These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t‐PBM) with near‐infrared light is a noninvasive neuromodulation technique that has shown potential for several neuropsychiatric disorders. However, its efficacy in OCD remains to be fully explored. This study aimed to review the literature on inflammation in OCD, detailing associations with T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, and elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, and IL‐6. We also examined the hypothesis‐based potential of t‐PBM in targeting these inflammatory pathways of OCD, focusing on mechanisms such as modulation of oxidative stress, regulation of immune cell function, reduction of proinflammatory cytokine levels, deactivation of neurotoxic microglia, and upregulation of BDNF gene expression. Our review suggests that t‐PBM could be a promising, noninvasive intervention for OCD, with the potential to modulate underlying inflammatory processes. Future research should focus on randomized clinical trials to assess t‐PBM's efficacy and optimal treatment parameters in OCD. Biomarker analyses and neuroimaging studies will be important in understanding the relationship between inflammatory modulation and OCD symptom improvement following t‐PBM sessions.

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“…In humans, PBM administered as laser acupuncture with a wavelength of 810 nm relieved postoperative pain in patients with traumatic rib fractures and this was confirmed in a randomized-controlled trial (RCT) [42]. In the setting of general anesthesia, tPBM (810 nm) had been reported to ameliorate mice with a perioperative neurocognitive disorder caused by isoflurane inhalation anesthesia [43]. Tsai [44] speculated in 2021 that "tPBM might possess general anesthetic effects on the brain".…”

Section: Introductionmentioning

confidence: 96%

“Optoanesthesia”: The Application of Transcranial Photobiomodulation to General Anesthesia

Tsai¹

2022

OJAnes

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General anesthesia relies on pharmacological anesthetics. However, some side effects of anesthetics have been observed. Non-pharmacological transcranial photobiomodulation (tPBM) as an adjuvant treatment may reduce the dosage of pharmacological anesthetics while maintaining anesthetic depth. The inhibitory effects of tPBM in terms of central nervous system depression render it a potential approach for inducing general anesthesia. Alteration of quantum processes of neuronal microtubules, the mechanisms of general anesthesia on consciousness, may occur in response to tPBM treatments. Further, tPBM as an adjuvant treatment may facilitate the distribution of the pharmacological anesthetics in the brain. The analgesic effects of photobiomodulation (PBM) are acknowledged, and PBM has been used for regional analgesia. However, whether tPBM can be used for general anesthesia is unknown. Here, I define "optoanesthesia" as "the use of tPBM for general anesthesia". I hypothesize that optoanesthesia can act as a means of general anesthesia. Supporting evidence in the form of unconsciousness, amnesia, and immobilization is provided in this paper. In addition, the tPBM-induced frequent yawning (a manifestation of transient arousal-shift during the continuing loss of consciousness during induction of general anesthesia) observed incidentally in my previous study of tPBM preconditioning for seizures also supports the hypothesis. I further discuss the issues with respect to the pharmacokinetics, parameters of optoanesthesia such as wavelength and targeted brain regions, and apparatus design, as well as the compatibility of the optoanesthesia and the Bispectral Index Monitoring System during surgery. Future research is needed to prove this hypothesis.

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Transcranial Photobiomodulation Therapy Ameliorates Perioperative Neurocognitive Disorder Through Modulation of Mitochondrial Function in Aged Mice

Cited by 12 publications

References 69 publications

Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice

Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

“Optoanesthesia”: The Application of Transcranial Photobiomodulation to General Anesthesia

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