Transcranial magnetic stimulation in the treatment of schizophrenic symptoms: A double blind sham controlled study

Saba, Ghassen; Verdon, Claire-Marie; Kalalou, K.; Rocamora, J.F.; Dumortier, G.; Benadhira, René; Stamatiadis, L.; Vicaut, Éric; Lipski, Héloise; Januel, Dominique

doi:10.1016/j.jpsychires.2005.02.008

Cited by 73 publications

(38 citation statements)

References 22 publications

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“…Furthermore, three recent studies 9-11 using a double-blind, sham-controlled design have given inconsistent results. Significant improvement noticed by Hoffman et al, 9 using 1 Hz rTMS, was not replicated by Fitzgerald et al 10 and Saba et al, 11 who failed to find such differences in their studies. Considering the fact that successful rTMS of schizophrenia may be linked to stimulation frequency and symptom profile, there is a need for further studies to investigate the suitability and efficacy of 10 Hz, suprathreshold rTMS on schizophrenic negative symptoms with a parallel design.…”

mentioning

confidence: 83%

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Goyal

Nizamie²,

Desarkar³

2007

JNP

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The potential effect of repetitive transcranial magnetic stimulation (rTMS) on core positive and negative symptoms in schizophrenia has not yet been clearly established. The aim of this study was to examine the efficacy of adjuvant 10 Hz, suprathreshold left prefrontal rTMS in negative symptoms of schizophrenia in a double-blind sham-controlled design. Additionally, our study also investigated the suitability of applying the same stimulus condition on positive symptoms. Ten right-handed schizophrenia patients received sham or active 10 Hz suprathreshold rTMS to the left dorsolateral prefrontal cortex with psychopathology, depression and global improvement ratings before and after rTMS sessions. Compared to sham, active rTMS significantly improved negative symptoms, irrespective of change in depressive symptoms.

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mentioning

confidence: 83%

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Goyal

Nizamie²,

Desarkar³

2007

JNP

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“…These promising results were replicated with an extended duration of stimulation for 2 weeks [17] and with a higher intensity of magnetic field [18][19][20][21] . Conversely, the effect was not replicated by studies with a treatment period only up to 5 days [22,23] or when the magnetic field was administered in the subthreshold intensity [24,25] .…”

Section: Introductionmentioning

confidence: 92%

Effect of Low-Frequency rTMS on Electromagnetic Tomography (LORETA) and Regional Brain Metabolism (PET) in Schizophrenia Patients with Auditory Hallucinations

et al. 2007

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Background: Auditory hallucinations are characteristic symptoms of schizophrenia with high clinical importance. It was repeatedly reported that low frequency (≤1Hz) repetitive transcranial magnetic stimulation (rTMS) diminishes treatment-resistant auditory hallucinations. A neuroimaging study elucidating the effect of rTMS in auditory hallucinations has yet to be published. Objective: To evaluate the distribution of neuronal electrical activity and the brain metabolism changes after low-frequency rTMS in patients with auditory hallucinations. Methods: Low-frequency rTMS (0.9 Hz, 100% of motor threshold, 20 min) applied to the left temporoparietal cortex was used for 10 days in the treatment of medication-resistant auditory hallucinations in schizophrenia (n = 12). The effect of rTMS on the low-resolution brain electromagnetic tomography (LORETA) and brain metabolism (¹⁸FDG PET) was measured before and after 2 weeks of treatment. Results: We found a significant improvement in the total and positive symptoms (PANSS), and on the hallucination scales (HCS, AHRS). The rTMS decreased the brain metabolism in the left superior temporal gyrus and in interconnected regions, and effected increases in the contralateral cortex and in the frontal lobes. We detected a decrease in current densities (LORETA) for the beta-1 and beta-3 bands in the left temporal lobe whereas an increase was found for beta-2 band contralaterally. Conclusion: Our findings implicate that the effect is connected with decreased metabolism in the cortex underlying the rTMS site, while facilitation of metabolism is propagated by transcallosal and intrahemispheric connections. The LORETA indicates that the neuroplastic changes affect the functional laterality and provide the substrate for a metabolic effect.

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“…123 After exclusion of this study, the difference between active and sham rTMS increased (Cohen d = 0.88). In the 2 studies not included in the meta-analysis, one had insufficient data to calculate an effect size 124 and the other had not yet been published. 125 Rosa and colleagues treated 11 people with schizophrenia on clozapine with refractory auditory hallucinations over 10 days with low frequency rTMS or sham treatment.…”

Section: Rtms For the Treatment Of Schizophreniamentioning

confidence: 99%

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

Boyer

Kreyenbuhl

Kelly

et al. 2009

Schizophrenia Bulletin

803

537

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Transcranial magnetic stimulation in the treatment of schizophrenic symptoms: A double blind sham controlled study

Cited by 73 publications

References 22 publications

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Effect of Low-Frequency rTMS on Electromagnetic Tomography (LORETA) and Regional Brain Metabolism (PET) in Schizophrenia Patients with Auditory Hallucinations

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

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