Transcranial magnetic stimulation identifies cortical excitability changes in monosymptomatic nocturnal enuresis

Khedr, Eman M.; El-Fetoh, Noha Abo; Elbeh, Khaled; Baky, Ahmed Abdel; Gamal, Rania M.; El-Hammady, Dina H.; Korashy, Fatma

doi:10.1016/j.neucli.2015.02.001

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…The neurophysiological assessment of cortical excitability was performed in patients and healthy volunteers using TMS, as previously published by our group in other clinical conditions [16][17][18][19][20][21][22]. The studied parameters consisted of: resting and active motor thresholds (RMT and AMT), cortical silent period (CSP), transcallosal inhibition (TCI), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF).…”

Section: Neurophysiological Assessmentmentioning

confidence: 99%

“…This deficient inhibition is thought to have a neurophysiological signature that is an increased level of cortical excitability [25,33]. In a number of studies of our group, transcranial magnetic stimulation (TMS) of motor cortex has been used to evaluate both cortical facilitatory and inhibitory mechanisms in different groups of patients [16][17][18][19][20][21][22]. In OCD a recent meta-analysis [31] was published and concluded that there is deficient cortical inhibition in OCD.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Khedr

Elbeh

Elserogy

et al. 2016

Neurophysiologie Clinique/Clinical Neurophysiology

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Section: Neurophysiological Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Khedr

Elbeh

Elserogy

et al. 2016

Neurophysiologie Clinique/Clinical Neurophysiology

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“…Functional enuresis may be primary with no prior period of sustained dryness or secondary with recurrence of nocturnal bed wetting after more than 6 months of dryness. Secondary NE is usually precipitated by upper airway obstruction, urinary tract infection, chronic constipation, ADHD, conduct disorder, specific phobia, generalized anxiety, or depression (Khedr et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Primary NE may be either monosymptomatic nocturnal enuresis (MNE) with normal daytime voiding patterns or non-monosymptomatic NE caused by overactive bladder and presented by daytime wetting, urinary frequency, urgency, hesitancy and interrupted stream with variable-sized wet patches, repeated lower urinary or genital pain, and awakening after wetting (Khedr et al 2015;Telli et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Primary monosymptomatic nocturnal enuresis: an etiological study

Bahnasy

El-Heneedy

El-Seidy

et al. 2018

Egypt J Neurol Psychiatry Neurosurg

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Background: Nocturnal enuresis (NE) is a very common chronic pediatric problem with bad psychological consequences. Methods: Forty primary monosymptomatic nocturnal enuresis (MNE) children and 20 healthy controls were recruited in the study and subjected to history taking, neurological and urological examinations, and psychological assessment using the Arabic-translated and validated version of child behavior checklist, sleep architecture studying through onenight polysomnography (PSG), and vasopressin levels determination both diurnal and nocturnal. Results: Enuretic children had positive family history of NE in 42.5%, inverted vasopressin circadian rhythm in 52.5% and PSG changes in the form of increased N3 deep sleep % of total sleep time (TST), sleep stage transition index (SSTI), periodic limb movement index (PLMI), and snore index. Enuretic children PSG showed decreased deep sleep latency, N1% of TST, N2% of TST, and REM % of TST. The child behavior checklist showed higher anxious depressed symptoms, social problem, attention problems, and internalizing problems in enuretic children than control subjects. Conclusions: MNE is a heterogeneous disorder with multiple factors interplay in its pathogenesis. So, the management must be tailored patient by patient according to the dominating etiology.

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“…В исследовании возбудимости коры головного мозга методом транскраниальной магнитной стимуляции пациенты с ночным энурезом демонстрировали патологически повышенную возбудимость и снижение функции ингибирующих компонентов головного мозга, что свидетельствует о морфофункциональной неполноценности ЦНС [12]. Таким образом, гипотеза, что аномально глубокий сон у детей способствует ночному энурезу, не находит однозначных научных подтверждений.…”

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Psychosomatic comorbid conditions in children with enuresis

Летифов

Бойко

Летифова

2020

Ross. vestn. perinatol. pediatr.

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Enuresis is a considerable medical and socio-psychological problem. The pathophysiology of enuresis remains unknown; none of the existing theories can explain its nature in full. The article reviews the studies devoted to the role of obstructive sleep disturbances in the occurrence of enuresis. The mentioned sleep disturbances in children are associated with other related disorders: pulmonary hypertension, developmental delay, sleepwalking, attention deficit and hyperactivity disorder, obstructive sleep apnea syndrome and enuresis. Numerous studies confirm the correlation of the mentioned syndromes. The obstruction of the upper respiratory tract during sleep is accompanied by an increase in the efforts of the respiratory muscles and negative intrathoracic pressure, which is associated with high atrial natriuretic peptide and low antidiuretic hormone levels. In most cases the surgical removal of respiratory tract obstruction (adenotonsillectomy) leads to significant improvement or complete resolution of enuresis. This category of patients requires a comprehensive interdisciplinary approach to the examination and treatment by the pediatricians, psycho-neurologists and ENT specialists.

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Transcranial magnetic stimulation identifies cortical excitability changes in monosymptomatic nocturnal enuresis

Cited by 12 publications

References 20 publications

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Primary monosymptomatic nocturnal enuresis: an etiological study

Psychosomatic comorbid conditions in children with enuresis

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