Transcranial Magnetic Stimulation for Tinnitus: Influence of Tinnitus Duration on Stimulation Parameter Choice and Maximal Tinnitus Suppression

Ridder, Dirk De; Verstraeten, Edwin; Kelen, Karolien Van der; Mulder, Gert De; Sunaert, Stefan; Verlooy, Jan; Heyning, Paul Van de; Møller, Aage R.

doi:10.1097/01.mao.0000178146.91139.3c

Cited by 190 publications

(173 citation statements)

References 30 publications

(42 reference statements)

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“…Indeed, the results we obtained in the opened eyes condition could be of particular interest to improve rTMS protocols in tinnitus. In concordance with De Ridder et al (2005) who observed best rTMS results with a frequency of 20 Hz, our data suggest that using subjects' individual beta frequency to modulate cortical excitability could be of potential interest in tinnitus. And as Weisz et al (2012) suggested, enlarging stimulation areas to non-auditory pathways (such as the parietal lobe) might improve tinnitus sufferers' condition.…”

Section: Discussionsupporting

confidence: 89%

Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Houdayer

Teggi

Velikova

et al. 2015

Clinical Neurophysiology

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HIGHLIGHTS• We used sLORETA to study the cerebral activity in normoacousic tinnitus sufferers.• EEG sources were decreased in left temporal and inferior parietal gyri in patients.• Cortico-thalamo-cortical circuits can be involved without thalamic deafferentation. ABSTRACTObjective: To better characterize brain circuits dysfunctions in normoacousic tinnitus sufferers. Methods: 17 normoacousic chronic, unilateral high-pitched tinnitus sufferers (6 females, 43.6 ± 9.8 y.o, disease duration 22 ±35 months) underwent a 29-channel resting-state electroencephalography (EEG -5 min opened-eyes, 5 min closed-eyes) and auditory oddball paradigm for event-related potentials analyses (ERPs -NI, P2 and P300). Cortical 3D distribution of current source density was computed with sLORETA. Results were compared with 17 controls (9 females, 45.7 ± 15.1 y.o). Results: Eyes opened, tinnitus sufferers had lower alpha and beta sources in the left inferior parietal lobule. Eyes closed, tinnitus sufferers had decreased alpha sources in the left inferior temporal and post-central gyri, and low gamma sources in the left middle temporal gyrus. EEG data did not correlate with tinnitus sufferers' clinical features. Subjects with tinnitus had shorter Nl and P2 latencies. P300 did not differ between groups. sLORETA solutions showed decreased sources of these ERPs in the left inferior temporal gyrus in the tinnitus group. Conclusions: We showed cortico-thalamo-cortical involvements in normoacousic tinnitus with hyperexcitability of the left auditory cortex and inferior temporal gyrus. Significance: This might reflect processes of maladaptive cortical plasticity and memory consolidation. Further validation is needed to establish the value of this tool in customizing therapeutic approach.

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Section: Discussionsupporting

confidence: 89%

Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Houdayer

Teggi

Velikova

et al. 2015

Clinical Neurophysiology

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“…A recent analysis of our fi rst 114 TMS sessions performed in unilateral tinnitus demonstrated that TMS had a good effect ( 1 80% transient suppression) in 28 of the patients studied (25%), a partial effect (21-80% suppression) in 32 (28%) and no effect (0-20% suppression) in 54 (47%). The amount of tinnitus suppression depended on the duration of the tinnitus: the longer the tinnitus exists, the less suppression that can be obtained by TMS [20] . Our studies furthermore indicate that the optimal stimulation frequency depends on the duration of the tinnitus, and tinnitus of recent origin is better suppressed by high-frequency stimulation ( 1 10 Hz), chronic tinnitus by low-frequency stimulation ( !…”

Section: Discussionmentioning

confidence: 99%

Primary and Secondary Auditory Cortex Stimulation for Intractable Tinnitus

Ridder

Mulder

Verstraeten³

et al. 2006

ORL

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141

102

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Introduction: Recent research suggests tinnitus is a phantom phenomenon based on hyperactivity of the auditory system, which can be visualized by functional neuroimaging, and transiently modulated by transcranial magnetic stimulation (TMS). We present the results of the first implanted electrodes on the primary and secondary auditory cortex after a successful TMS suppression. Methods and Materials: Twelve patients underwent an auditory cortex implantation, 10 for unilateral and 2 for bilateral tinnitus, based on >50% suppression applying TMS. Results were analyzed for pure tone tinnitus and white noise tinnitus. Results: TMS results in 77% pure tone tinnitus and 67% white noise reduction. Electrical stimulation via an implanted electrode results in a mean of 97% pure tone tinnitus and 24% white noise suppression. Mean Visual Analogue Scale score decreases from 9.5 to 1.5 for pure tone and from 8.8 to 6.8 for white noise postoperatively. Discussion: Pure tone tinnitus might be the conscious percept of focal neuronal hyperactivity of the auditory cortex. Once visualized, this hyperactivity can be modulated by neurostimulation. Conclusion: The preliminary results of the first implantations suggest that patients with unilateral pure tone tinnitus are good surgical candidates for electrode implantation and permanent electrical stimulation of the auditory cortex, provided that the tinnitus is of recent origin and can be suppressed by TMS.

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“…2 lower). 13 Since her tinnitus was intractable, neuromodulation trials were proposed, consisting of TMS of the right auditory cortex in the 1-, 3-, 5-, and 10-Hz tonic mode 18 as well as in the theta-, alpha-, and beta-burst mode. 7,8 Bifrontal tDCS 49 and TENS of the C-2 nerve at different frequencies did not bring any benefit.…”

Section: History and Examinationmentioning

confidence: 99%

“…All episodic artifacts were removed from the stream of the EEG. Average Fourier cross-spectral matrices were computed for bands delta (2-3.5 Hz), theta (4-7.5 Hz), alpha (8-12 Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and gamma (30.5-45 Hz).…”

Section: Connectivity Changes Between Cases 1 Andmentioning

confidence: 99%

Anterior cingulate implants for tinnitus: report of 2 cases

Ridder

Joos

Vanneste

2016

JNS

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893case report J Neurosurg 124: [893][894][895][896][897][898][899][900][901] 2016 N oNpulsatile tinnitus is the perception of a sound in the absence of an external source and is therefore often considered a phantom sound. 30 It is related to abnormal activity in the auditory and nonauditory brain areas, 48 which can be altered by neuromodulation techniques. 24 As tinnitus is most commonly related to auditory deafferentation 20 with 30,31 or without 59 audiometric hearing loss, it has been regarded as maladaptive auditory memory traces 5 attempting to reduce the inherent auditory uncertainty associated with auditory deafferentation.11 Apart from abnormal activity, pathological functional connectivity is also associated with the presence of tinnitus as demonstrated by electroencephalography (EEG), 57 magnetoencephalography (MEG), 38,39 and functional MRI (fMRI). 26,27 Thus, it has been proposed that the phenomenologically unified percept of tinnitus can be considered an emergent property of multiple, parallel, dynamically changing, and partially overlapping subnetworks, each with a specific spontaneous oscillatory pattern and functional connectivity signature. 17 Functional imaging studies using source-localized EEG and MEG have shown that tinnitus distress is related to a network involving the anterior cingulate cortex (ACC), anterior insula, and parahippocampal area, 6,22,56 whereas the auditory cortex is involved in the perceived tinnitus intensity. 44 The distress subnetwork is predominantly lateralized to the right, in contrast to a similar network encoding depression that is lateralized to the left. 21 The loudness and distress networks are clearly separable even though they interact. Communication between these different subnetworks is proposed to occur at hubs, brain areas that are involved in multiple subnetworks simultaneously. These hubs can take part in each separable subnetwork at different frequencies. ComabbreviatioNs ACC = anterior cingulate cortex; BA = Brodmann area; BOLD = blood oxygen level-dependent; d = dorsal; DLPFC = dorsolateral prefrontal cortex; EEG = electroencephalography; fMRI = functional MRI; HADS = Hospital Anxiety Depression Scale; MEG = magnetoencephalography; NRS = numeric rating scale; r = repetitive; sg = subgenual; sLORETA = standardized low-resolution electromagnetic tomography; tDCS = transcranial direct current stimulation; TENS = transcutaneous electrical nerve stimulation; TMS = transcranial magnetic stimulation; TQ = tinnitus questionnaire. Tinnitus can be distressful, and tinnitus distress has been linked to increased beta oscillatory activity in the dorsal anterior cingulate cortex (dACC). The amount of distress is linked to alpha activity in the medial temporal lobe (amygdala and parahippocampal area), as well as the subgenual (sg)ACC and insula, and the functional connectivity between the parahippocampal area and the sgACC at 10 and 11.5 Hz. The authors describe 2 patients with very severely distressing intractable tinnitus who underwent transcranial magnetic st...

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Transcranial Magnetic Stimulation for Tinnitus: Influence of Tinnitus Duration on Stimulation Parameter Choice and Maximal Tinnitus Suppression

Abstract: TMS of the auditory cortex is capable of modifying tinnitus perception for a very short time. The maximal amount of suppression and best stimulation frequency depends on the tinnitus duration.

Cited by 190 publications

References 30 publications

Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Primary and Secondary Auditory Cortex Stimulation for Intractable Tinnitus

Anterior cingulate implants for tinnitus: report of 2 cases

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