Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Houdayer, Elise; Teggi, Roberto; Velikova, S.; Gonzalez-Rosa, Javier J.; Bussi, Mario; Comi, Giancarlo; Leocani, Letizia

doi:10.1016/j.clinph.2015.01.027

Cited by 26 publications

(15 citation statements)

References 72 publications

(71 reference statements)

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“…Moreover, functional changes in the cortex associated with auditory activity can be revealed in tinnitus patients using high-resolution EEG. Source analysis of event-related potentials (ERPs) is a sensitive method to assess the changes evoked by tinnitus in the central nervous system [ 17 ]. After tinnitus matching, as the frequency of tinnitus was used to deviant stimuli, active areas in the brain in the difference between standard stimuli and deviant stimuli can be recognized in the tinnitus group and the normal control group by EEG source analysis.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study of EEG Source Analysis Based Repetitive Transcranial Magnetic Stimulation for the Treatment of Tinnitus

Wang

Feng

et al. 2015

PLoS ONE

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ObjectiveRepetitive Transcranial Magnetic Stimulation (rTMS) is a novel therapeutic tool to induce a suppression of tinnitus. However, the optimal target sites are unknown. We aimed to determine whether low-frequency rTMS induced lasting suppression of tinnitus by decreasing neural activity in the cortex, navigated by high-density electroencephalogram (EEG) source analysis, and the utility of EEG for targeting treatment.MethodsIn this controlled three-armed trial, seven normal hearing patients with tonal tinnitus received a 10-day course of 1-Hz rTMS to the cortex, navigated by high-density EEG source analysis, to the left temporoparietal cortex region, and to the left temporoparietal with sham stimulation. The Tinnitus handicap inventory (THI) and a visual analog scale (VAS) were used to assess tinnitus severity and loudness. Measurements were taken before, and immediately, 2 weeks, and 4 weeks after the end of the interventions.ResultsLow-frequency rTMS decreased tinnitus significantly after active, but not sham, treatment. Responders in the EEG source analysis-based rTMS group, 71.4% (5/7) patients, experienced a significant reduction in tinnitus loudness, as evidenced by VAS scores. The target site of neuronal generators most consistently associated with a positive response was the frontal lobe in the right hemisphere, sourced using high-density EEG equipment, in the tinnitus patients. After left temporoparietal rTMS stimulation, 42.8% (3/7) patients experienced a decrease in tinnitus loudness.ConclusionsActive EEG source analysis based rTMS resulted in significant suppression in tinnitus loudness, showing the superiority of neuronavigation-guided coil positioning in dealing with tinnitus. Non-auditory areas should be considered in the pathophysiology of tinnitus. This knowledge in turn can contribute to investigate the pathophysiology of tinnitus.

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“…Event-related potentials (ERPs) are time-locked and phase-locked brain responses associated with particular perceptual, cognitive, motor and emotional states [ 62 , 66 – 68 ]. They are of two types: exogenous and endogenous.…”

Section: Methodsmentioning

confidence: 99%

Electroencephalographic evaluation of acoustic therapies for the treatment of chronic and refractory tinnitus

Alonso-Valerdi

Ibarra-Zarate

Tavira-Sánchez

et al. 2017

BMC Ear Nose Throat Disord

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BackgroundTo date, a large number of acoustic therapies have been applied to treat tinnitus. The effect that produces those auditory stimuli is, however, not well understood yet. Furthermore, the conventional clinical protocol is based on a trial-error procedure, and there is not a formal and adequate treatment follow-up. At present, the only way to evaluate acoustic therapies is by means of subjective methods such as analog visual scale and ad-hoc questionnaires.MethodsThis protocol seeks to establish an objective methodology to treat tinnitus with acoustic therapies based on electroencephalographic (EEG) activity evaluation. On the hypothesis that acoustic therapies should produce perceptual and cognitive changes at a cortical level, it is proposed to examine neural electrical activity of patients suffering from refractory and chronic tinnitus in four different stages: at the beginning of the experiment, at one week of treatment, at five weeks of treatment, and at eight weeks of treatment. Four of the most efficient acoustic therapies found at the moment are considered: retraining, auditory discrimination, enriched acoustic environment, and binaural.DiscussionEEG has become a standard brain imaging tool to quantify and qualify neural oscillations, which are basically spatial, temporal, and spectral patterns associated with particular perceptual, cognitive, motor and emotional processes. Neural oscillations have been traditionally studied on the basis of event-related experiments, where time-locked and phase-locked responses (i.e., event-related potentials) along with time-locked but not necessary phase-locked responses (i.e., event-related (de) synchronization) have been essentially estimated. Both potentials and levels of synchronization related to auditory stimuli are herein proposed to assess the effect of acoustic therapies.Trial registrationRegistration Number: ISRCTN14553550. ISRCTN Registry: BioMed Central. Date of Registration: October 31st, 2017.

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“…According to statistical analysis, it is impossible to localize the P300 component because these components are related to a wide cerebral cortex network [143]. Furthermore, sLORETA algorithm results show that in patients suffering from normoacousic tinnitus, EEG sources reduce in left temporal and inferior parietal gyri [144].…”

Section: Bluschke Et Al [127]mentioning

confidence: 99%

A systematic review of EEG source localization techniques and their applications on diagnosis of brain abnormalities

Asadzadeh

Rezaii

Beheshti

et al. 2020

Journal of Neuroscience Methods

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In recent years, multiple noninvasive imaging modalities have been used to develop a better understanding of the human brain functionality, including positron emission tomography, single-photon emission computed tomography, and functional magnetic resonance imaging, all of which provide brain images with millimeter spatial resolutions. Despite good spatial resolution, time resolution of these methods are poor and values are about seconds. Electroencephalography (EEG) is a popular non-invasive electrophysiological technique of relatively very high time resolution which is used to measure electric potential of brain neural activity. Scalp EEG recordings can be used to perform the inverse problem in order to specify the location of the dominant sources of the brain activity. In this paper, EEG source localization research is clustered as follows: solving the inverse problem by statistical method (37.5%), diagnosis of brain abnormalities using common EEG source localization methods (18.33%), improving EEG source localization methods by non-statistical strategies (3.33%), investigating the effect of the head model on EEG source imaging results (12.5%), detection of epileptic seizures by brain activity localization based on EEG signals (20%), diagnosis and treatment of ADHD abnormalities (8.33%). Among the available methods, minimum norm solution has shown to be very promising for sources with different depths. This review investigates diseases that are diagnosed using EEG source localization techniques. In this review we provide enough evidence that the effects of psychiatric drugs on the activity of brain sources have not been enough investigated, which provides motivation for consideration in the future research using EEG source localization methods.Index Terms-EEG signals, source localization, the inverse problem, head model, brain abnormalities, time resolution.S. Beheshti is with the

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“…Para abordar este problema, se han desarrollado técnicas de análisis de acoplamiento entre frecuencias, en las que se evalúa cómo la fase de la actividad en bandas de baja frecuencia modula la actividad neuronal local en cada área a través de la modulación de la amplitud de la actividad en alta frecuencia 46 , permitiendo así estudiar tanto la conectividad entre regiones de una red, como la actividad local en cada punto de la red neuronal. Por medio de la utilización de estas herramientas se ha estudiado la fisiopatología del tinnitus, observándose que en condiciones normales durante la vigilia existe una coordinación de la actividad entre el tálamo y la corteza cerebral por medio de actividad en banda alfa 47 . Cuando un estímulo ingresa al sistema auditivo genera actividad en banda gamma a nivel cortical.…”

Section: Alteraciones Cerebrales En Tinnitus: Evidencia Conductual Y unclassified

Tinnitus: Una patología cerebral

et al. 2019

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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El tinnitus es un síntoma caracterizado por la percepción de un sonido en ausencia de un estímulo externo. Si bien su fisiopatología puede involucrar una alteración a nivel del funcionamiento del oído interno, la percepción de éste y el grado de molestias asociadas dependen de modificaciones de redes cerebrales cognitivas y emocionales. En la presente revisión, se abordan los cambios que existen a nivel coclear, de tronco encefálico, tálamo y la extensa red cerebral que dan cuenta del tinnitus, discutiendo como esta nueva conceptualización tiene importantes implicancias clínicas, permitiendo una mejor comprensión de los síntomas asociados al tinnitus, sus comorbilidades, y el desarrollo de nuevas estrategias terapéuticas.

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“…The advances in EEG source localization methods have enabled the investigation of electric neuronal activity inside the brain, and provide the possibility to reveal brain areas associated with heat-sensitization responses. Among them, the standardized low-resolution brain electromagnetic tomography (sLORETA) allowing 3-D localization of cortical EEG generators both in the time Ozaki et al 2012) and frequency domain (Houdayer et al 2015;Jaiswal et al 2010;Justen et al 2014), has been successfully applied to electrophysiological characterization of intracranial responses to pain (Shao et al 2012;Stern et al 2006). Recent studies have confirmed sLORETA to accurately localize neural generators of brain electrical activity (Mulert et al 2004a;Pascual-Marqui 2002a;Walla et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

Wang

Zhang

et al. 2015

Cogn Neurodyn

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Moxibustion is under active research as a complementary and alternative treatment for various diseases such as pain. ''Heat-sensitization'' responses have been reported during suspended moxibustion, whose occurrence is associated with significantly better therapeutic effects. The present study aimed to investigate the cortical activities of this interesting phenomenon by a standardized low-resolution brain electromagnetic tomography. We performed electroencephalography recording in a group of patients with chronic low back pain before, during, and after moxibustion treatment at Yaoyangguan (DU3) areas. 11 out of 21 subjects experienced strong heatsensitization during moxibustion, which were accompanied with significant decreases of current densities in the beta frequency bands in prefrontal, primary and second somatosensory, and cingulate cortices, as well as increased current densities in the alpha2 band in the left insula. No changes were detected in patients without sensitization responses, or in the post-moxibustion phase of either group. These data indicated widespread activity changes across different frequency bands during heat-sensitization. Cortical oscillatory activities could be used to evaluate the ''heatsensitization'' responses during suspended moxibustion.

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Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Cited by 26 publications

References 72 publications

A Pilot Study of EEG Source Analysis Based Repetitive Transcranial Magnetic Stimulation for the Treatment of Tinnitus

Electroencephalographic evaluation of acoustic therapies for the treatment of chronic and refractory tinnitus

A systematic review of EEG source localization techniques and their applications on diagnosis of brain abnormalities

Tinnitus: Una patología cerebral

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

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