Transcranial Electrotherapy Stimulation Modulates Stress-Induced C-Fos Expression in Peripheral Blood Mononuclear Cells in Rats With Different Resistance to Stress

Abstract

TRANSCRANIAL ELECTROTHERAPY STIMULATION MODULATES STRESS-INDUCED C-FOS EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN RATS WITH DIFFERENT RESISTANCE TO STRESSis a recognized and unique peripheral biomarker of stress, stress-associated and psychiatric disorders. In our article, we studied the possibility of correction of transcranial electrotherapy stimulation (TES-therapy) of stress-induced c-fos expression in PBMC of rats with high or low resistance to stress, predicted from differences in their modified forced swim test results. As a model of combined stress, a modified forced swim test and orthostatic stress were used. The expression of the c-fos gene in PBMC was carried out by real-time polymerase chain reaction. Relative c-fos expression in low resistance control group (Me=0,03) was statistically significantly less than that in high resistance control group (Me=1,3). TES-therapy was accompanied by a statistically significant increase in relative c-fos expression (Me=1) in low resistance treatment group. In high resistance treatment group TES-therapy, on the contrary, was accompanied by a decrease in relative c-fos expression (Me=0,15). These effects reflect the systemic stress limiting action of TES-therapy, which has a pronounced homeostatic character.

The Influence of Transcranial Electrical Stimulation Therapy on the Dynamics of Anxiety in Rats With Rotenone-Induced Parkinsonism Model

“…Лебедевым [12]. Данный метод используется для лечения широкого круга различных заболеваний, так как вызывает ряд эффектов -нейропротекторный, нейротрофический, противовоспалительный, антиоксидантный и другие, благодаря активации опиоидэргической системы [13].…”