Transcranial Doppler Pattern after Intracarotid Papaverine and Prostaglandin E&lt;sub&gt;1&lt;/sub&gt; Incorporated in Lipid Microsphere in Patients with Vasospasm

Kanamaru, Kenji; Waga, Shiro; Kuga, Yoshihiro; Nakamura, Fumiaki; Kamata, Naoki

doi:10.2176/nmc.38.suppl_152

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…In the present study, we demonstrated that in principal it is possible to incorporate PGE 2 into (85:15) PLGA microspheres using a new and innovative cosolvent emulsion method. Even if the incorporation and release of another prostaglandin (PGE 1 ) from a lipid microsphere has already been described by Kanamura et al21 for its use in the treatment of vasospasm, to our knowledge the present report demonstrates for the first time the incorporation and controlled release of PGE 2 from PLGA microspheres. There are various experimental studies with different PLGA‐based scaffolds22–24 and microspheres25–31 loaded with signaling molecules and growth factors for different purposes in tissue engineering, as summarized in Table I.…”

Section: Discussionmentioning

confidence: 43%

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Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres

Brochhausen

Zehbe

Watzer

et al. 2008

J Biomedical Materials Res

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Prostaglandin E(2) (PGE(2)) is an arachidonic acid metabolite involved in physiological homeostasis and numerous pathophysiological conditions. Furthermore, it has been demonstrated that prostaglandins have a stimulating effect not only on angiogenesis in situ and in vitro but also on chondrocyte proliferation in vitro. Thus, PGE(2) represents an interesting signaling molecule for various tissue engineering strategies. However, under physiological conditions, PGE(2) has a half-life time of only 10 min, which limits its use in biomedical applications. In the present study, we investigated if the incorporation of PGE(2) into biodegradable poly-L-lactide-co-glycolide microspheres results in a prolonged release of this molecule in its active form. PGE(2)-modified microspheres were produced by a cosolvent emulsification method using CHCl(3) and HFIP as organic solvents and PVA as emulsifier. Thirteen identical batches were produced; and to each batch 1.0 mL of serum-free medium was added. The medium was removed at defined time points and then analyzed by gas chromatography tandem mass spectrometry (GC/MS/MS) to measure the residual PGE(2) content. In this study we demonstrated the prolonged release of PGE(2), showing a linear increase over the first 12 h, followed by a plateau and a slow decrease. The microspheres were further characterized by scanning electron microscopy.

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Section: Discussionmentioning

confidence: 43%

“… Surface erosion due to hydrolytic degradation [two different PLGA polymers from a previous study (corresponding to our previous results from Ref. 21) after 0, 40, and 80 days]. …”

Section: Resultsmentioning

confidence: 93%

Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres

Brochhausen

Zehbe

Watzer

et al. 2008

J Biomedical Materials Res

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“…Thus, papaverine has been used in conjunction with nimodipine, nicardipine, prostaglandins to enhance it’s safety and efficacy. 150 …”

Section: Clinical Use Of Intracarotid Drugsmentioning

confidence: 99%

Intracarotid Delivery of Drugs

Joshi¹,

Meyers

Ornstein³

2008

Anesthesiology

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The major efforts to selectively deliver drugs to the brain in the last decade have relied on smart molecular techniques to penetrate the blood brain barrier while intraarterial drug delivery has drawn relatively little attention. In the last decade there have been rapid advances in endovascular techniques. Modern endovascular procedures can permit highly targeted drug delivery by intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart-neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggests that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.

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“…It is probably unlikely that this receptor is responsible for endocytosis of large liposomes (>50-nm) [2,70]. The 50-nm unilamellar liposomes, containing papaverine and Prostaglandin E, have been shown to augment cerebral blood flow [2,71,72]. A novel method to deliver chemotherapeutic drugs in such a situation is to use immunoliposomes.…”

Section: Specific Transport Mechanismsmentioning

confidence: 99%

Targeting the Brain

2007

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Drug delivery to the brain has remained one of the most vexing problems in translational neuroscience research. This review rationalizes the strategies to target drugs to the brain. Factors such as the speed of intervention, the scale of intervention, the state of BBB, and the permissible risks, will all be critical in deciding how best to deliver drugs to a target site in the brain for a specific clinical situation.

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Transcranial Doppler Pattern after Intracarotid Papaverine and Prostaglandin E<sub>1</sub> Incorporated in Lipid Microsphere in Patients with Vasospasm

Abstract: We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid

Cited by 6 publications

References 20 publications

Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres

Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres

Intracarotid Delivery of Drugs

Targeting the Brain

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Transcranial Doppler Pattern after Intracarotid Papaverine and Prostaglandin E<sub>1</sub> Incorporated in Lipid Microsphere in Patients with Vasospasm

Abstract: We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid

Cited by 6 publications

References 20 publications

Immobilization and controlled release of prostaglandin E2 from poly‐L‐lactide‐co‐glycolide microspheres

Immobilization and controlled release of prostaglandin E2 from poly‐L‐lactide‐co‐glycolide microspheres

Intracarotid Delivery of Drugs

Targeting the Brain

Contact Info

Product

Resources

About

Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres

Immobilization and controlled release of prostaglandin E₂ from poly‐L‐lactide‐co‐glycolide microspheres