Transcranial direct current stimulation modulates brain functional connectivity in autism

Zhou, Tianyi; Kang, Jiannan; Li, Zheng; Chen, He; Li, Xiaoli

doi:10.1016/j.nicl.2020.102500

Cited by 17 publications

(16 citation statements)

References 79 publications

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“…Third, as discussed above, performing a task (i.e., concurrent cognitive remediation training) during prefrontal tDCS might alter the hypothesized cathodal tDCS effects; although we expected that left dlPFC cathodal tDCS would be inhibitory, we instead observed a positive rsFC change in the medial PFC that is usually produced by an excitatory intervention. When compared to another tDCS study in ASD individuals [68] that performed a reversed montage (i.e., anode placement over the left dlPFC, in contrast to our study), we revealed a right-lateralized, instead of interhemispheric, enhancement of rsFC. This implies that the direction of the electric field may play a role in promoting differential tDCS effects in brain network organization.…”

Section: Neuropsychological and Neurophysiological Mechanisms Of Pref...contrasting

confidence: 75%

Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Han¹,

Chan²,

Shea³

et al. 2022

Brain Stimulation

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Section: Neuropsychological and Neurophysiological Mechanisms Of Pref...contrasting

confidence: 75%

Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Han¹,

Chan²,

Shea³

et al. 2022

Brain Stimulation

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“…In this study, the anode electrode was placed in the left DLPFC. Abnormalities in the prefrontal area are closely related to symptoms such as attention distribution disorder, weak executive ability, and organization disorder in patients with ASD ( Zhou et al, 2020 ). Dickinson et al (2016) showed that there is an imbalance between excitation and inhibition in the neural circuits of patients with ASD, particularly in the DLPFC.…”

Section: Discussionmentioning

confidence: 99%

Effect of Transcranial Direct Current Stimulation on the Mismatch Negativity Features of Deviated Stimuli in Children With Autism Spectrum Disorder

Sun

Zhao

Cheng³

et al. 2022

Front. Neurosci.

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Autism spectrum disorder (ASD) is a devastating mental disorder in children. Currently, there is no effective treatment for ASD. Transcranial direct current stimulation (tDCS), which is a non-invasive brain stimulation neuromodulation technology, is a promising method for the treatment of ASD. However, the manner in which tDCS changes the electrophysiological process in the brain is still unclear. In this study, we used tDCS to stimulate the dorsolateral prefrontal cortex area of children with ASD (one group received anode tDCS, and the other received sham tDCS) and investigated the changes in evoked EEG signals and behavioral abilities before and after anode and sham stimulations. In addition to tDCS, all patients received conventional rehabilitation treatment. Results show that although conventional treatment can effectively improve the behavioral ability of children with ASD, the use of anode tDCS with conventional rehabilitation can boost this improvement, thus leading to increased treatment efficacy. By analyzing the electroencephalography pre- and post-treatment, we noticed a decrease in the mismatch negativity (MMN) latency and an increase in the MMN amplitude in both groups, these features are considered similar to MMN features from healthy children. However, no statistical difference between the two groups was observed after 4 weeks of treatment. In addition, the MMN features correlate well with the aberrant behavior checklist (ABC) scale, particularly the amplitude of MMN, thus suggesting the feasibility of using MMN features to assess the behavioral ability of children with ASD.

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“…An application of tDCS in children and adolescents with ASD has been shown to increase brain functional connectivity 71 and cause improvement in behavioral and cognitive symptoms 72–74 . Both cathodal and anodal tDCS stimulation are adequate in successfully reducing ASD symptoms even in medication‐resistant patients 75–77 …”

Section: Non‐invasive Brain Stimulationmentioning

confidence: 99%

Brain stimulation: a therapeutic approach for the treatment of neurological disorders

et al. 2021

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Brain stimulation has become one of the most acceptable therapeutic approaches in recent years and a powerful tool in the remedy against neurological diseases. Brain stimulation is achieved through the application of electric currents using non‐invasive as well as invasive techniques. Recent technological advancements have evolved into the development of precise devices with capacity to produce well‐controlled and effective brain stimulation. Currently, most used non‐invasive techniques are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), whereas the most common invasive technique is deep brain stimulation (DBS). In last decade, application of these brain stimulation techniques has not only exploded but also expanded to wide variety of neurological disorders. Therefore, in the current review, we will provide an overview of the potential of both non‐invasive (rTMS and tDCS) and invasive (DBS) brain stimulation techniques in the treatment of such brain diseases.

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Transcranial direct current stimulation modulates brain functional connectivity in autism

Cited by 17 publications

References 79 publications

Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Effect of Transcranial Direct Current Stimulation on the Mismatch Negativity Features of Deviated Stimuli in Children With Autism Spectrum Disorder

Brain stimulation: a therapeutic approach for the treatment of neurological disorders

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