Transcranial Direct Current Stimulation in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)

Bandeira, Igor D.; Guimarães, Rachel Silvany Quadros; Jagersbacher, João Gabriel; Barretto, Thiago Lima; Jesus-Silva, Jéssica Regina de; Nunes, Samantha; Argollo, Nayara; Lucena, Rita

doi:10.1177/0883073816630083

Cited by 93 publications

(86 citation statements)

References 44 publications

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“…Anodal tDCS causes locally reduced GABA activity, while cathodal stimulation reduces glutamatergic neurotransmission (Stagg et al, 2009). These concepts support the idea that the application of cathodal tDCS over frontal regions might restore the pathologically altered excitation/inhibition balance and have some beneficial effects for this patient population (Bandeira et al, 2016). …”

Section: Towards Individualized Tes Interventionssupporting

confidence: 66%

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Yavari

Nitsche

Ekhtiari

2017

Front. Hum. Neurosci.

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During recent years, non-invasive brain stimulation, including transcranial electrical stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular, have created new hopes for treatment of neurological and psychiatric diseases. Despite promising primary results in some brain disorders, a more widespread application of tES is hindered by the unsolved question of determining optimum stimulation protocols to receive meaningful therapeutic effects. tES has a large parameter space including various montages and stimulation parameters. Moreover, inter- and intra-individual differences in responding to stimulation protocols have to be taken into account. These factors contribute to the complexity of selecting potentially effective protocols for each disorder, different clusters of each disorder, and even each single patient. Expanding knowledge in different dimensions of basic and clinical neuroscience could help researchers and clinicians to select potentially effective protocols based on tES modulatory mechanisms for future clinical studies. In this article, we propose a heuristic spatiomechanistic framework which contains nine levels to address tES effects on brain functions. Three levels refer to the spatial resolution (local, small-scale networks and large-scale networks) and three levels of tES modulatory effects based on its mechanisms of action (neurochemical, neuroelectrical and oscillatory modulations). At the group level, this framework could be helpful to enable an informed and systematic exploration of various possible protocols for targeting a brain disorder or its neuroscience-based clusters. Considering recent advances in exploration of neurodiversity at the individual level with different brain mapping technologies, the proposed framework might also be used in combination with personal data to design individualized protocols for tES in the context of precision medicine in the future.

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Section: Towards Individualized Tes Interventionssupporting

confidence: 66%

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Yavari

Nitsche

Ekhtiari

2017

Front. Hum. Neurosci.

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“…As the authors suggest, this modulation of oscillatory activity during sleep might have been a relevant mechanism to regulate sleep-dependent restorative processes related to behavioral inhibition or executive functions (Munz et al, 2015). Another study reported significant improvement of visual attention and inhibitory control after five consecutive once-daily anodal tDCS sessions over the left dorsolateral prefrontal cortex (2 mA for 30 min) in children aged between 6 and 16 years (Bandeira et al, 2016). The results showed that processing speed, detection of stimuli, and the ability to switch from one activity to another were improved by tDCS.…”

Section: Adhd and Psychiatric Disordersmentioning

confidence: 97%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2017

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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“…Interestingly, cathodal stimulation improved No-Go accuracy compared with anodal and sham tDCS, indicating improved inhibitory control [84]. Another open-label study of 9 children with ADHD showed an improvement in selective attention and a decrease in errors in the inhibitory control task with 2 mA anodal tDCS over the left DLPFC [85•]. A third study in 14 children with ADHD using slow oscillating tDCS applied for 5 sessions of 5 minutes each separated by 1 minute, with anodal electrodes at F3 and F4 (current strength, 0–250 µA; oscillating frequency, 0.75 Hz) showed a shorter reaction time on a Go-No-Go task the morning after stimulation at non-REM sleep stage 2, whereas there was no difference in alertness between groups [86].…”

Section: Tdcs Therapeutic Potentialmentioning

confidence: 99%

Transcranial Magnetic and Direct Current Stimulation in Children

Hameed

Dhamne

Gersner

et al. 2017

Curr Neurol Neurosci Rep

106

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Promising results in adult neurologic and psychiatric disorders are driving active research into transcranial brain stimulation techniques, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), in childhood and adolescent syndromes. TMS has realistic utility as an experimental tool tested in a range of pediatric neuropathologies such as perinatal stroke, depression, Tourette syndrome, and autism spectrum disorder (ASD). tDCS has also been tested as a treatment for a number of pediatric neurologic conditions, including ASD, attention-deficit/hyperactivity disorder, epilepsy, and cerebral palsy. Here, we complement recent reviews with an update of published TMS and tDCS results in children, and discuss developmental neuroscience considerations that should inform pediatric transcranial stimulation.

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Transcranial Direct Current Stimulation in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)

Cited by 93 publications

References 44 publications

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Applications of transcranial direct current stimulation in children and pediatrics

Transcranial Magnetic and Direct Current Stimulation in Children

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