Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Kim, Yeo Jin

doi:10.12786/bn.2017.10.e4

Cited by 3 publications

(2 citation statements)

References 83 publications

(86 reference statements)

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“…On the other hand, Bystad and colleagues (2016a) found no significant differences in memory improvement between active and placebo tDCS in patients with Alzheimer's disease. In Alzheimer's disease, studies using tDCS have shown inconsistent results ( Kim, 2016 ). In healthy individuals, tDCS is also associated with mixed results ( Tremblay et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study

Bystad

Storø

Gundersen

et al. 2020

Heliyon

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The aim of this study was to investigate whether transcranial Direct Current Stimulation (tDCS) could improve verbal memory functions in healthy old and younger participants. We hypothesized that active tDCS led to significantly improved memory function, compared to placebo tDCS. Forty healthy participants (20 old and 20 younger participants) were included in the study. We applied a novel stimulation protocol, where six sessions of anodal tDCS were administrated during two consecutive days. Each tDCS session lasted 30 min. The current intensity was 2mA and the stimulation area was the left temporal lobe at T3 in the 10–20 EEG system. Immediate recall, delayed recall and recognition memory were assessed with California Verbal Learning Test II (CVLT-II) and executive functions were assessed with the Trail Making Test (TMT) before the first tDCS session and after the last tDCS session. Half of the participants received placebo tDCS, whereas the other half received active tDCS. We did not reveal any significant differences between active and placebo tDCS in memory functions. However, there was a significant difference between active and placebo tDCS in executive function measured by the Trail Making Test (TMT). This experimental study failed to reveal significant differences between active and placebo accelerated tDCS for verbal memory functions. However, accelerated tDCS was found to be well-tolerated in this study.

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Section: Introductionmentioning

confidence: 99%

Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study

Bystad

Storø

Gundersen

et al. 2020

Heliyon

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“…The anode increases cortical excitability while the cathode leads to cortical hypoexcitability [4,5]. tDCS has demonstrated efficacy in improving recognition memory performance [6][7][8] or face-naming association memory [9] in AD (Kim [10]). We therefore aimed to report the effects of this intervention on verbal cued recall performance in an individual with AD.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Response to Cueing after Left Prefrontal Transcranial Direct Current Stimulation in Alzheimers disease

Masse¹,

Chopard²,

Magnin³

et al. 2018

Neuropsychiatry

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BackgroundSeveral studies have reported the potential benefits of transcranial Direct Current Stimulation (tDCS) to improve memory performance in patients with neuropsychiatric disorders. In Alzheimer's disease (AD), memory profile is characterized by a core deficit in ability to benefit of the cueing. So far, only a few authors showed improvement in recognition memory task after anodal tDCS over different brain regions. Methods and findingsIn a double-blind design, we assessed the effect of 10 anodal tDCS sessions over the left dorsolateral prefrontal cortex on verbal cued recall in a 69-year-old patient with probable AD. This man underwent one active stimulation (30 min of 2 mA anodal tDCS, twice a day, for 5 consecutive days) 3 weeks after receiving one sham stimulation (30 min of 0 mA anodal tDCS, twice a day, for 5 consecutive days). After active tDCS, our results showed improved Index of Sensitivity to Cueing (ISC) by 35% and 33%, for both total and delayed recall, respectively, compared to a 1.5% decrease and an increase of only 9% with sham tDCS. In addition, active tDCS resulted in a decrease of 67% in the number of intrusions compared to an increase of 8% for sham tDCS. The treatment was well tolerated and no serious side-effects were reported at any time. ConclusionsThese results suggest that tDCS could be used as a safety adjunctive therapeutic tool in AD.

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Cognitive Function Improvement in Mouse Model of Alzheimer’s Disease Following Transcranial Direct Current Stimulation

et al. 2020

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Anodal transcranial direct current stimulation (tDCS) is a painless noninvasive method that reportedly improves cognitive function in Alzheimer’s disease (AD) by stimulating the brain. However, its underlying mechanism remains unclear. Thus, the present study investigates the cognitive effects in a 5xFAD AD mouse model using electrophysiological and pathological methods. We used male 5xFAD C57BL/6J and male C57BL/6J wild-type mice; the dementia model was confirmed through DNA sequencing. The verified AD and wild-type mice were randomly assigned into four groups of five mice each: an induced AD group receiving tDCS treatment (Stim-AD), an induced AD group not receiving tDCS (noStim-AD), a non-induction group receiving tDCS (Stim-WT), and a non-induction group not receiving tDCS (noStim-WT). In the Stim group, mice received tDCS in the frontal bregma areas at an intensity of 200 µA for 20 min. After 2 weeks of treatment, we decapitated the mice, removed the hippocampus from the brain, confirmed its neuronal activation through excitatory postsynaptic potential (EPSP) recording, and performed molecular experiments on the remaining tissue using western blots. EPSP significantly increased in the Stim-AD group compared to that in the noStim-AD, which was comparable to that in the non-induced groups, Stim-WT and noStim-WT. There were no significant differences in cyclic amp-response element binding protein (CREB), phosphorylated CREB (pCREB), and Brain-derived neurotrophic factor (BDNF) levels in the Stim-AD group compared to those in the noStim-AD group. This study demonstrated that a tDCS in both frontal lobes of a transgenic 5xFAD mouse model affects long-term potentiation, indicating possible enhancement of cognitive function.

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Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Cited by 3 publications

References 83 publications

Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study

Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study

Improvement of Response to Cueing after Left Prefrontal Transcranial Direct Current Stimulation in Alzheimers disease

Cognitive Function Improvement in Mouse Model of Alzheimer’s Disease Following Transcranial Direct Current Stimulation

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