Abstract:Anodal transcranial direct current stimulation (tDCS) is a painless noninvasive method that reportedly improves cognitive function in Alzheimer’s disease (AD) by stimulating the brain. However, its underlying mechanism remains unclear. Thus, the present study investigates the cognitive effects in a 5xFAD AD mouse model using electrophysiological and pathological methods. We used male 5xFAD C57BL/6J and male C57BL/6J wild-type mice; the dementia model was confirmed through DNA sequencing. The verified AD and wi… Show more
“…It is an accepted notion that tDCS modulates brain activity partly by affecting synaptic functioning. Several studies showed that tDCS altered synaptic efficacy leading to long term potentiation or depression, depending on the direction of field polarity (Fritsch et al, 2010;Grassi et al, 2017;Kim et al, 2020;Kronberg et al, 2020Kronberg et al, , 2016Lafon et al, 2016;Podda et al, 2016;Yu et al, 2019). Most of these DCS studies utilized hippocampal slices.…”
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
“…It is an accepted notion that tDCS modulates brain activity partly by affecting synaptic functioning. Several studies showed that tDCS altered synaptic efficacy leading to long term potentiation or depression, depending on the direction of field polarity (Fritsch et al, 2010;Grassi et al, 2017;Kim et al, 2020;Kronberg et al, 2020Kronberg et al, , 2016Lafon et al, 2016;Podda et al, 2016;Yu et al, 2019). Most of these DCS studies utilized hippocampal slices.…”
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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