Transcatheter Cerebral Revascularization in the Treatment of Atherosclerotic Lesions of the Brain

Transcatheter Technologies in Treating Brain Atherosclerosis Complicated by Chronic Cerebrovascular Insufficiency

“…These data are supported by the work of many authors who conducted both experimental and clinical studies dedicated to extracranial laser exposure of the brain [11]- [13] [15] [39] [40]. The after-treatment gradual increase in the mass of brain tissue suggests regenerative processes developing in it [34] [39] [41]. These data are also indirectly confirmed by experimental and clinical studies that prove the possibility of regenerative processes in the brain tissue [42].…”

“…Naturally, improved blood circulation of the more affected hemisphere contributes to its functional recovery. Improved blood circulation of a less atherosclerosis-affected contralateral hemisphere also helps to improve its functionality, and at the same time, due to stimulation of collateral circulation, improves blood flow to the other hemisphere [2] [9] [34]. Thus, the two-way blood circulation improvement leads to an overall functional recovery of the brain.…”

“…Target high-energy laser irradiation allows destroying atherosclerotic tissues and restoring the patency and lumen of atherosclerotic vessels without affecting the vascular wall [9] [33] [34]. Resultant decomposition products of atherosclerotic tissues are of a very small size, 2 -6 micrometers [32] [33]; they are naturally utilized, so they do not require any means of distal protection [34].…”

“…The mechanism of low-energy laser exposure lies in the powerful stimulation of natural physiological angiogenesis [2] [34] [35] causing collateral and capillary revascularization of tissues [2] [36]- [38]. At the same time, the deeply penetrating laser energy stimulates the metabolic processes in neurons increasing their energy resource through effects on mitochondria and providing neuroprotection [34]. These data are supported by the work of many authors who conducted both experimental and clinical studies dedicated to extracranial laser exposure of the brain [11]- [13] [15] [39] [40].…”

“…The method allows working on convoluted vessels of small diameter. Efficacy and safety of this method is proved in earlier experimental and clinical studies [2] [9] [30]- [34].…”