Intracerebral Transcatheter Laser Photobiomodulation Therapy in the Treatment of Binswanger's Disease and Vascular Parkinsonism: Research and Clinical Experience

Maksimovich, Ivan V.

doi:10.1089/photob.2019.4649

Cited by 16 publications

(27 citation statements)

References 35 publications

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“…In transcatheter intracerebral PBMT, the energy of the helium-neon laser extends to 20-40 mm [5,41,48]. Therefore, the impact of the laser energy exposure reaches the vascular wall, the blood, and considerably large areas of the cerebral tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the impact of the helium-neon laser on the cerebral tissues restores the metabolic processes and stimulates neurogenesis and tissue regeneration. Since atherosclerosis is a systemic disease that affects, to varying degrees, the entire cerebral arterial bed, the transcatheter intracerebral PBMT was performed from two directions [4,5,44,48]. Laser irradiation of the region where the stroke had developed and the contralateral side region improved blood circulation and tissue metabolism in the two hemispheres of the brain which facilitated rapid physiology-based rehabilitation of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…This instrument has a diameter of 25-100 micrometers and a perpendicularly polished distal end that is connected to the laser system [41][42][43][44]. The fiber-optic instrument is then made to reach the distal regions of the intracerebral arteries where laser irradiation has to be performed [41][42][43][44]48].…”

Section: Test Groupmentioning

confidence: 99%

“…PBMT was conducted manually using the ULF-01 continuous helium-neon laser ("Anod" manufacturing company, the city of Bryansk, Russia) [43,48]. The following were the parameters of the intracerebral transcatheter laser exposure: wavelength -632.8 nanometers; laser output power -25-45 mW; fiber output power -24-44 mW; treatment session duration -1200-2400 s; ray spot diameter of the vessel -1-2 mm; and average dose during the treatment -29-106 J.…”

Section: Test Groupmentioning

confidence: 99%

“…This program automatically records the changes occurring in the vascular image in the corresponding phase of contrast in real-time [4,5,42]. The results reflect the state of the main cerebral blood supply and also the intensity of intracerebral angiogenesis and collateral and capillary revascularization [5,43,44,48]. If the blood supply is not restored completely after PBMT, the manipulation may be repeated.…”

Section: Test Groupmentioning

confidence: 99%

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Transcatheter Intracerebral Laser Photobiomodulation Therapy for Treatment of the Consequences of Ischemic Stroke with Distal Atherosclerotic Lesion

Maksimovich¹

2021

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The present research is dedicated to the application of intracerebral laser PBMT for the treatment of the consequences of ischemic stroke. The effectiveness of intracerebral laser PBMT is compared to that of the conservative therapy methods. Recent studies have demonstrated a high potential of laser technology PBMT in the treatment of various ischemic lesions of the brain. A total of 836 patients who had experienced ischemic strokes of different degrees of severity in the period ranging from 6 months to 6 years prior to the treatment were included in the research. The age of these patients ranged between 29 and 81 years (average age: 74.9 years). There were 593 men (70.93%) and 243 women (29.07%). The patients were divided into two groups - the Test Group and the Control Group. The Test Group comprised 511 (61.12%) patients with distal lesions of the intracerebral arteries. These patients underwent transcatheter intracerebral laser PBMT. The Control Group comprised 325 (38.88%) patients with similar distal lesions of the intracerebral arteries. These patients, however, received the conservative treatment. The Test Group patients exhibited good clinical results in 259 (87.21%) cases after small focal strokes, in 94 (60.26%) cases after medium focal strokes, and in 12 (20.69%) cases after macro-focal strokes. The Test Group patients exhibited satisfactory clinical results in 33 (11.11%) cases after small focal strokes, - in 39 (25.00%) cases after medium focal strokes, and- in 22 (37.93%) cases after macro-focal strokes. In the Control Group, 51 (21.07%) patients exhibited good clinical results after small focal strokes, while none of the patients exhibited good results after medium focal strokes and macro-focal strokes. In the Control Group, satisfactory clinical results were exhibited by 60 (24.79%) patients after small focal strokes and 8 (19.05%) patients after medium focal strokes, while none of the patients exhibited satisfactory results after macro-focal strokes. Transcatheter intracerebral laser PBMT is an effective, pathogenetically substantiated method for the treatment of the consequences of ischemic stroke. This method enables the restoration of daily-life activities and cognitive and mental functions, thereby enabling the patients to be fully active in their lives again.

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Section: Discussionmentioning

confidence: 99%