OBJECTIVES
Transcatheter aortic valve replacement (TAVR) has become a treatment option for otherwise inoperable or high risk patients. Currently TAVR is performed with a combination of fluoroscopy and transesophageal echocardiography, which has visual limitations including a two dimensional view and poor soft tissue contrast. Real-time magnetic resonance imaging (rtMRI) guidance overcomes these limitations with a three dimensional view of anatomical structures, improved soft tissue contrast, and allows pinpoint accuracy of device delivery. To date a device clinically available in the US has not been used for rtMRI TAVR. We present our results using the CoreValve® device.
METHODS
The Medtronic CoreValve® delivery catheter system was minimally modified by the investigators to be MRI compatible by replacing the stainless steel components with fluoroplastic resin and high density polyethylene components. Eight swine ranging between 60 and 90 kg underwent rtMRI guided TAVR with an active guidewire via a left subclavian approach.
RESULTS
Two imaging planes (long axis view and short axis view) were utilized simultaneously for real-time imaging during implantation. Successful deployment was performed without rapid ventricular pacing or cardiopulmonary bypass. Post-deployment images were acquired to evaluate the final valve position in addition to valvular and cardiac function.
CONCLUSIONS
Our results show that the CoreValve® can be easily and effectively deployed from the left subclavian approach by utilizing rtMRI guidance, a minimally modified valve delivery catheter system, and an active guidewire. This method allows superior visualization prior to deployment, thereby allowing deployment of the valve with pinpoint accuracy. rtMRI has the added benefit of the ability to perform immediate post-procedural functional assessment, while eliminating the morbidity of radiation exposure, rapid ventricular pacing, contrast media renal toxicity, and a more invasive procedure. Use of a commercially available device brings this rtMRI guided approach closer to a clinical reality.