Transcapillary fluid dynamics during the menstrual cycle

Øian, Pål; Tollan, A; Fadnes, Hans Olav; Noddeland, Harald; Maltau, Jan Martin

doi:10.1016/0002-9378(87)90364-4

Cited by 47 publications

(56 citation statements)

References 11 publications

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“…The decrease in plasma volume often observed during the midluteal phase has been suggested to be due to changes in colloid osmotic pressures and plasma albumin shifts, which increase filtration from the intravascular to the interstitial spaces (33). Thus the shifts in ␤ 0 that were observed in this study may be due to greater interstitial fluid accumulation when estrogen and progesterone are elevated.…”

Section: Discussionsupporting

confidence: 49%

“…In support of this theory, numerous studies have identified that transcapillary fluid shifts are affected by estrogen and progesterone (33,37,38). The decrease in plasma volume often observed during the midluteal phase has been suggested to be due to changes in colloid osmotic pressures and plasma albumin shifts, which increase filtration from the intravascular to the interstitial spaces (33).…”

Section: Discussionmentioning

confidence: 98%

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Effects of menstrual cycle and oral contraceptive use on calf venous compliance

Meendering

Torgrimson

Houghton

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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Numerous studies have shown that the female sex hormones estrogen and progesterone have multiple effects on the vasculature. Thus our goal was to investigate the effects of estrogen and progesterone on calf venous compliance by looking for cyclic changes during the early follicular, ovulatory, and midluteal phases of the menstrual cycle and during high and low hormone phases of oral contraceptive use. Additionally, we wanted to compare the venous compliance of normally menstruating women, oral contraceptive users, and men. We studied eight normally menstruating women (23 Ϯ 1 yr of age) during the early follicular, ovulatory, and midluteal phases of the menstrual cycle. Nine triphasic oral contraceptive users (21 Ϯ 1 yr of age) were studied during weeks of high and low hormone concentrations. Eight men (23 Ϯ 1 yr of age) were studied twice within 2-4 wk. With the use of venous occlusion plethysmography with mercury in-Silastic strain gauges, lower limb venous compliance was measured by inflating a venous collection cuff that was placed on the thigh to 60 mmHg for 8 min and then reducing the pressure to 0 mmHg at a rate of 1 mmHg/s. Venous compliance was calculated as the derivative of the pressure-volume curves. There were no differences between early follicular, ovulatory, and midluteal phases of the menstrual cycle or between high and low hormone phases of oral contraceptive use (P Ͼ 0.05). Male venous compliance was significantly greater than in normally menstruating women (P Ͻ 0.001) and oral contraceptive users (P Ͻ 0.002). These data support a sex difference but also suggest that venous compliance does not change with menstrual cycle phase or during the course of oral contraceptive use. estrogen; progesterone; orthostatic tolerance WHEN HUMANS ASSUME AN UPRIGHT posture, blood progressively pools in the compliant veins of the lower limbs. This action decreases central blood volume and venous return and subsequently elicits orthostatic stress by challenging blood pressure (2, 34). Greater lower limb venous compliance has been linked to orthostatic intolerance, which suggests that greater venous compliance augments venous pooling and therefore elicits greater reductions in venous return and stroke volume. For example, Halliwill et al. (12) report that the cardiovascular responses to orthostatic stress are less when blood pooling within the lower limbs is minimized. Furthermore, greater orthostatic tolerance has been found in subjects with decreased venous compliance compared with subjects having highly compliant veins (21, 39). Although Hernandez et al. (14) found no difference in orthostatic tolerance between subject groups with high and low venous compliance, the subjects with the highest venous compliance showed the earliest increases in heart rate and decreases in stroke volume during lower body negative pressure (15). These data suggest that lower limb venous compliance may have a direct impact on cardiovascular responses to orthostatic stress and possibly orthostatic tolerance.It has been clearly demon...

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 98%

Effects of menstrual cycle and oral contraceptive use on calf venous compliance

Meendering

Torgrimson

Houghton

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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“…2015), labile protein stores (Swick and Benevenga 1977), and the accompanying body water (Oian et al. 1987; Ew 1996). While investigators have often reasoned that these short‐term individual daily fluctuations in body weight are primarily due to fluctuations in TBW and other components of FFM, to the best of our knowledge, there is only one published study on the composition of that variation when subjects are not making an effort to lose or gain weight (i.e., unrestricted free‐living conditions) and this study was limited to four subjects under inpatient conditions (Dole et al.…”

Section: Introductionmentioning

confidence: 99%

Composition of two-week change in body weight under unrestricted free-living conditions

et al. 2017

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The composition of weight change has a large impact on energy balance calculations. Composition of long‐term weight change interventions is well‐documented, but information on short‐term weight change under unrestricted free‐living conditions is limited. The composition and energy density of the changes in body weight during 2‐week free‐living conditions were analyzed in adults from two cohorts: cohort 1 (n = 24) included participants from the reproducibility subset of the Observing Protein and Energy Nutrition study; cohort 2 (n = 22) included participants who were studied under free‐living conditions in an ongoing study in the Chicago area. Change in body weight, total body water (TBW) by stable isotope dilution (cohort 1), and fat mass (FM) and fat‐free mass (FFM) by serial DXA (cohort 2) were measured. To determine the fractional composition of the change in body weight we analyzed the linear associations between changes in body weight and changes in body composition. In the combined dataset, the average change in body weight (0.26 ± 1.2 kg) was consistent with being in energy balance. Average change in body weight was associated with the change in TBW (P < 0.0001) in cohort 1 and the change in FFM (P = 0.0002) in cohort 2. A unit change in body weight was composed of 84% change in FFM in the combined dataset indicating that 2‐week fluctuation in body weight is largely composed of FFM. The energy density of 1–3 kg short‐term changes in body weight averaged 2380 kcal/kg.

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“…It is well known that estrogens cause PV expansion, most likely via their actions on the capillary endothelium to increase the transcapillary escape of proteins and thus water (22,36). These changes in oncotic pressure will induce changes in body fluid distribution within the extracellular fluid, independent of sodium concentration.…”

Section: Pv Expansionmentioning

confidence: 99%

“…Primarily, it is known that estrogens favor fluid retention by activating the renin-angiotensin-aldosterone system and that progesterone is able to antagonize this event (21). Estrogen enhances vasodilation and capillary permeability and acts centrally to lower the operating set point of plasma osmolality (Posm) (a leftward shift in AVP sensitivity) (21,22,28,30,38). Progesterone competes directly with the same mineralocorticoid receptor as aldosterone, which may cause a transient natriuresis (20).…”

mentioning

confidence: 99%

Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest

Sims¹,

Rehrer²,

Bell³

et al. 2008

Journal of Applied Physiology

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Sims ST, Rehrer NJ, Bell ML, Cotter JD. Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest. J Appl Physiol 105: 121-127, 2008. First published April 24, 2008 doi:10.1152/japplphysiol.01331.2007.-This study was conducted to investigate effects of an acute sodium load on resting plasma volume (PV) and renal mechanisms across the menstrual cycle of endurancetrained women with natural (NAT) or oral contraceptive pill (OCP) controlled cycles. Twelve women were assigned to one of two groups, according to their usage status: 1) OCP [n ϭ 6, 29 yr (SD 6), 59.4 kg (SD 3.2)], or 2) NAT [n ϭ 6, 24 yr (SD 5), 61.3 kg (SD 3.6)]. The sodium load was administered as a concentrated sodium chloride/ citrate beverage (164 mmol Na ϩ /l, 253 mosmol/kgH2O, 10 ml/kg body mass) during the last high-hormone week of the OCP cycle (OCP high) or late luteal phase of the NAT cycle (NAThigh) and during the low-hormone sugar pill week of OCP (OCP low) or early follicular phase of the NAT cycle (NAT low). The beverage (ϳ628 ml) was ingested in seven portions across 60 min. Over the next 4 h, PV expanded more in the low-hormone phase for both groups (timeaveraged change): OCP low 6.1% (SD 1.1) and NATlow 5.4% (SD 1.2) vs. OCP high 3.9% (SD 0.9) and NAThigh 3.5% (SD 0.8) (P ϭ 0.02). The arginine vasopressin increased less in the low-hormone phase [1.63 (SD 0.2) and 1.30 pg/ml (SD 0.2) vs. 1.82 (SD 0.3) and 1.57 pg/ml (SD 0.5), P ϭ 0.0001], as did plasma aldosterone concentration (ϳ64% lower, P ϭ 0.0001). Thus PV increased more and renal hormone sensitivity was decreased in the low-hormone menstrual phase following sodium/fluid ingestion, irrespective of OCP usage. oral contraceptive pill; citrate; hypervolemia; hyperhydration; estradiol; progesterone BODY WATER AND ELECTROLYTE balance are critical for normal cellular function and maintaining adequate blood and plasma volume (PV) and osmolality, yet natural and synthetic female sex hormones have various effects on water and electrolyte balance. Thus understanding the interactions of female sex hormones and their synthetic analogs and the fluid regulatory system is crucial. The two most influential female sex hormones are estrogen and progesterone, both of which change in concentration across the menstrual cycle and are governed by oral contraceptive pill (OCP) usage. These two hormones influence sodium and water distribution and thus fluid compartment volumes and dynamics. Primarily, it is known that estrogens favor fluid retention by activating the renin-angiotensin-aldosterone system and that progesterone is able to antagonize this event (21). Estrogen enhances vasodilation and capillary permeability and acts centrally to lower the operating set point of plasma osmolality (Posm) (a leftward shift in AVP sensitivity) (21,22,28,30,38). Progesterone competes directly with the same mineralocorticoid receptor as aldosterone, which may cause a transient natriuresis (20).Although the effects of estrogen and progesteron...

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Transcapillary fluid dynamics during the menstrual cycle

Cited by 47 publications

References 11 publications

Effects of menstrual cycle and oral contraceptive use on calf venous compliance

Effects of menstrual cycle and oral contraceptive use on calf venous compliance

Composition of two-week change in body weight under unrestricted free-living conditions

Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest

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