Transarterial Chemoembolization with Drug-eluting Beads Preloaded with Irinotecan as a First-Line Approach in Uveal Melanoma Liver Metastases: Tumor Response and Predictive Value of Diffusion-weighted MR Imaging in Five Patients

ObjectiveTo investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC).MethodsBetween October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging (local invasion, nodal involvement and according to the different groups — stage I, II and III). Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016.ResultsMedian follow-up period was 33 months and 45/89 (51%) deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement (P<0.001). Considering final histology as the reference standard, a preoperative ADC cut-off of 1.80×10–3 mm2/s could distinguish between stages I and II and an ADC value of ≤1.36×10–3 mm2/s was associated with stage III (P<0.001). Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs (P<0.001). ConclusionsADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC.

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“…Some studies have previously determined the ability of DW-MRI to detect, stage and assess tumor response in oncology (32,33,39,40). Liu et al .…”

Section: Discussionmentioning

confidence: 99%

Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer

Giganti

Ambrosi

Chiari

et al. 2017

Chinese Journal of Cancer Research

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“…The pretreatment ADC value of HCC has shown utility in predicting response to cTACE 23,42,51 and DEB-TACE, 52 demonstrating that lower pretreatment ADC values are more likely to respond to cTACE/DEB-TACE. It is postulated that lesions with a high degree of vascularity have more restricted diffusion (ie, lower ADC) making them a more ideal target for intraarterial therapy such as DEB-TACE.…”

Section: Discussionmentioning

confidence: 99%

Immediate post‐doxorubicin drug‐eluting beads chemoembolization Mr Apparent diffusion coefficient quantification predicts response in unresectable hepatocellular carcinoma: A pilot study

Kokabi

Camacho

Xing

et al. 2015

Magnetic Resonance Imaging

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“…More recently, Venturini et al found an 80% response rate following treatment of five patients with irinotecan (100 mg) drug-eluting beads (100 to 300 µm). 26 One patient achieved a complete response, two patients had a partial response, one patient achieved stable disease, and another patient had progressive disease. Follow-up ranged from 8 to 13 months (mean: 10.6 months), and all patients were alive at last follow-up.…”

Section: Drug-eluting Beadsmentioning

confidence: 93%

Transhepatic Therapies for Metastatic Uveal Melanoma

Eschelman

Gonsalves

Sato

2013

Semin intervent Radiol

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Despite successful treatment of the primary tumor, uveal melanoma has a propensity to metastasize to the liver. Prognosis is poor due to the very aggressive nature of these tumors. Because systemic therapies are relatively ineffective and patient survival correlates to disease control in the liver, locoregional therapies provide a means of prolonging survival. We review various techniques including chemoembolization, immunoembolization, radioembolization, arterial fotemustine infusion, and hepatic perfusion for the treatment of liver metastases from uveal melanoma.

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Transarterial Chemoembolization with Drug-eluting Beads Preloaded with Irinotecan as a First-Line Approach in Uveal Melanoma Liver Metastases: Tumor Response and Predictive Value of Diffusion-weighted MR Imaging in Five Patients

Cited by 26 publications

References 10 publications

Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer

Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer

Immediate post‐doxorubicin drug‐eluting beads chemoembolization Mr Apparent diffusion coefficient quantification predicts response in unresectable hepatocellular carcinoma: A pilot study

Transhepatic Therapies for Metastatic Uveal Melanoma

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