Immediate post‐doxorubicin drug‐eluting beads chemoembolization Mr Apparent diffusion coefficient quantification predicts response in unresectable hepatocellular carcinoma: A pilot study

Abstract

ADC relative change of ≥20% immediately post-DEB-TACE is an accurate predictor of objective and quantitative treatment response and prolonged survival in unresectable HCC.

Prognostic value of pretreatment diffusion-weighted magnetic resonance imaging for outcome prediction of colorectal cancer liver metastases undergoing 90Y-microsphere radioembolization

“…Both animal models and clinical studies have shown that necrotic lesions exhibit higher ADC values (Herneth et al 2003;Kokabi et al 2015). Necrosis can be interpreted as a sign of histopathologic tumor aggressiveness and hypoxia, eventually related to drug resistance and dismal outcome, which may explain the reduced susceptibility of lesions with higher ADC values to chemotherapeutic agents (Tredan et al 2007).…”

Diffusion-weighted imaging of the liver: Current applications

“…TACE-induced perilesional parenchymal changes negatively affect DWI in terms of overall accuracy. On the other hand, Kokabi et al[82] reported that an ADC change 3 h after TACE is an accurate predictor of treatment response and survival.…”

Interobserver variability of selective region‐of‐interest measurement protocols for quantitative diffusion weighted imaging in soft tissue masses: Comparison with whole tumor volume measurements

“…The technique of quantitative diffusion weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping has emerged as a potential method for the assessment of soft tissue masses (STMs). Recent work exploring the role of DWI and ADC mapping in the assessment of STMs includes the differentiation of benign and malignant peripheral STMs, the detection of recurrent tumors in the surgical bed, and the assessment of treatment response in STMs . The degree of cellularity of STMs affects the degree of restricted diffusion, as indicated by the ADC values within the lesions.…”

“…The evaluation and determination of optimal manual approaches for quantitative analysis of ADC values in terms of accuracy and reproducibility is important for proper use of ADC map data. Prior investigations on quantitative ADC measurements in STMs for characterization, detection of tumor recurrence and assessment of treatment response have relied on a manual approach …”