Interobserver variability of selective region‐of‐interest measurement protocols for quantitative diffusion weighted imaging in soft tissue masses: Comparison with whole tumor volume measurements

Abstract

While all selective and WTV measurements offer good to excellent interobserver agreement, the selective OB method of ADC measurement results in the closest values to WTV measurements and requires significantly less measurement time than that required for the WTV method.

Diffusion Weighted Imaging for Differentiating Benign from Malignant Orbital Tumors: Diagnostic Performance of the Apparent Diffusion Coefficient Based on Region of Interest Selection Method

“…During clinical usage, ROI RDSS was the most commonly used ROI selection method for measuring the ADC values. Previous studies indicated that since the ROI RDSS was commonly placed on the area where the tumor showed relative higher signal intensity on DW images, ROI RDSS tended to reflect the most solid, cellular or viable portion of the tumor (1120). However, our study results indicated that inter-reader variability was an major limitation of ROI RDSS .…”

DWI in the Assessment of Breast Lesions

“…Lesion ADC measurements differ significantly depending on the ROI selection approach, which can range from sampling a small subregion to whole tumor 3D ROI methods, Figure 5. Differences in ADC are most dramatic in large, heterogeneous, and non mass lesions [37, 52, 53]. Some studies have reported that a smaller ROI placed over the most hypointense ADC area may provide better discriminating performance by reflecting the worst pathology within a heterogeneous lesion [37, 53].…”

“…Some studies have reported that a smaller ROI placed over the most hypointense ADC area may provide better discriminating performance by reflecting the worst pathology within a heterogeneous lesion [37, 53]. On the other hand, whole tumor measurement may allow better reproducibility [52]. Semi-automated ROI selection techniques further show promise to improve efficiency, accuracy, and reproducibility of breast lesion ADC measures [54].…”

Characterization of indeterminate soft tissue masses referred for biopsy: What is the added value of contrast imaging at 3.0 tesla?

“…The two readers selected a region of interest (ROI) within each STM so that the ROIs included the largest possible area of the STM, but carefully excluded surrounding extra‐lesional tissues. The slice used for each ROI was chosen as the slice having with the lowest visual signal within the STM on the ADC map, according to prior work by Ahlawat and colleagues . Minimum and average ADC values were recorded for each lesion.…”