Trans-nasal OCT imaging of the small intestine (Conference Presentation)

Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices

“…These probe‐coupled devices were introduced into the small intestine via a custom‐fabricated, guide tube termed a transnasal introduction tube (TNIT) 32 . The TNIT is comprised of polyurethane material and has a length of 1.2 m, an outer diameter (OD) of 2.3 mm, and an inner diameter (ID) of 1.6 mm, similar in size and composition to feeding tubes such as nasogastric or nasojejunal tubes 32 . The introduction process involved inserting the TNIT through the nose of an unsedated subject, deploying the TNIT into the small intestine, and then threading the IPD and brush devices through the TNIT's lumen until their active ends protruded beyond the TNIT, at which point IPD measurements or brush samplings were taken.…”

“…The IPD system consisted of an isolation headstage (ISO‐Z, CWe Inc.), a bioamplifier (BMA‐200, CWe Inc.), analog‐to‐digital (A/D) converter (Power Lab 4/26; AD Instruments Inc.), and a computer 32 . The IPD data signal was detected via an isolation headstage, amplified (10×), digitized using an A/D converter, and recorded using LabChart software (ADInstruments Inc.) at 1000 samples/second.…”

“…Passively scanned M‐mode OCT probes were incorporated in intestinal potential difference (IPD) 31 and brush sampling devices that do not intrinsically employ image guidance. These probe‐coupled devices were introduced into the small intestine via a custom‐fabricated, guide tube termed a transnasal introduction tube (TNIT) 32 . The TNIT is comprised of polyurethane material and has a length of 1.2 m, an outer diameter (OD) of 2.3 mm, and an inner diameter (ID) of 1.6 mm, similar in size and composition to feeding tubes such as nasogastric or nasojejunal tubes 32 .…”