Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices

Otuya, David O.; Dechene, Nicholas M.; Poshtupaka, Darina; Carlson, Camella Joelle; Zemlok, Sarah K; Sevieri, Evan; Choy, Peter; Shore, Rachel E.; León-Peralta, Esmarline De; Cirio, Alissa A; Rihm, Tyler W; Krall, Alexander A.; Gavgiotaki, Evangelia; Dong, Jing; Silva, Sarah L; Baillargeon, Aaron; Baldwin, Grace; Gao, Anna H.; Jansa, Zachary; Barrios, Amilcar; Ryan, Erin; Bhat, Nitasha; Balmasheva, Indira; Chung, Anita; Grant, Catriona N.; Bablouzian, Ara; Beatty, Matthew; Ahsen, Osman O.; Tearney, Guillermo J.

doi:10.1002/lsm.23576

Cited by 4 publications

(2 citation statements)

References 46 publications

(83 reference statements)

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“…Furthermore, a miniaturized OCT catheter was manufactured (outer diameter of 3.8 mm, lateral resolution of ~7 µm, and axial resolution of ~6 μm) 68 . A passive, single-fiber probe in the gastrointestinal (GI) tracts of unsedated human patients 69 has been demonstrated and can be used to guide device placement. This probe conducts device-tissue physical contact sensing and obtains two-dimensional (2D) OCT images via M- to B-mode conversion.…”

Section: Optical Diagnosis and Therapymentioning

confidence: 99%

The LMIT: Light-mediated minimally-invasive theranostics in oncology

Fan,

Liu,

Gao

et al. 2024

Theranostics

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Minimally-invasive diagnosis and therapy have gradually become the trend and research hotspot of current medical applications. The integration of intraoperative diagnosis and treatment is a development important direction for real-time detection, minimally-invasive diagnosis and therapy to reduce mortality and improve the quality of life of patients, so called minimally-invasive theranostics (MIT). Light is an important theranostic tool for the treatment of cancerous tissues. Light-mediated minimally-invasive theranostics (LMIT) is a novel evolutionary technology that integrates diagnosis and therapeutics for the less invasive treatment of diseased tissues. Intelligent theranostics would promote precision surgery based on the optical characterization of cancerous tissues. Furthermore, MIT also requires the assistance of smart medical devices or robots. And, optical multimodality lay a solid foundation for intelligent MIT. In this review, we summarize the important state-of-the-arts of optical MIT or LMIT in oncology. Multimodal optical image-guided intelligent treatment is another focus. Intraoperative imaging and real-time analysis-guided optical treatment are also systemically discussed. Finally, the potential challenges and future perspectives of intelligent optical MIT are discussed.

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Section: Optical Diagnosis and Therapymentioning

confidence: 99%

The LMIT: Light-mediated minimally-invasive theranostics in oncology

Fan,

Liu,

Gao

et al. 2024

Theranostics

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show abstract

“…The imaging depth of OCT/OCM in most tissues is about 2–3 mm. However, its resolution is 10–100 times higher than that of ultrasound, with the advantages of non-invasive, high spatial resolution and 3D real-time imaging 8 , which can clearly display the structural characteristics and pathological changes of biological tissues and has shown great potential in the detection and clinical research of diseases such as cutaneous 9 , 10 , ophthalmic 11 , 12 , cardiovascular 13 , cervical diseases 14 , 15 , and gastrointestinal 16 . However, the use of OCT/OCM techniques for the study of human HSCR in-vivo or ex-vivo has not been explored so far.…”

Section: Introductionmentioning

confidence: 99%

Study on the application of optical coherence microscopy in Hirschsprung's disease

Song

Zeng

et al. 2023

Sci Rep

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To explore the clinical application value of optical coherence microscopy (OCM) in Hirschsprung’s disease. 109 HSCR patients were recuited in a Chinese hospital from January 2018 to July 2021. All the recruited patients underwent barium enema angiography preoperatively and the resected diseased intestinal tubes were evaluated intraoperatively. The OCM and the histopathological examination were performed successively on the surgical specimens, and the OCM images were compared with the relevant tissue sections to characterize different lesions. 10 non-HSCR fetal colorectal tissues at the same period were retained for OCM, the characteristics of which with and without HSCR under OCM imaging were analyzed. In the OCM images of in vitro tissue, it can be clearly observed that the scattering degree of HSCR narrow segment mucosal is high, glands and crypt structures are reduced or even atrophy, and the scattering degree of submucosal and intermuscular is low; In the dilated segment, the low scattering and high scattering are complex, and the muscle layer is obviously hypertrophy and structural disorder. Compared with the pathological findings, the OCM sensitivity, Kappa value, and AUC area reached 92.66%, 0.63, and 0.91, respectively. OCM can quickly and clearly display the structure of all layers of colorectal tissue, which is highly consistent with the corresponding histopathological examination results and has high sensitivity. which will provide a more reliable basis for OCM diagnosis of early HSCR, targeted biopsy and location of operative treatment, and has a certain potential for clinical application.

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Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices

et al. 2022

Self Cite

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Background/Objectives: Optical coherence tomography (OCT) uses low coherence interferometry to obtain depth-resolved tissue reflectivity profiles (M-mode) and transverse beam scanning to create images of two-dimensional tissue morphology (B-mode). Endoscopic OCT imaging probes typically employ proximal or distal mechanical beam scanning mechanisms that increase cost, complexity, and size. Here, we demonstrate in the gastrointestinal (GI) tracts of unsedated human patients, that a passive, single-fiber probe can be used to guide device placement, conduct device−tissue physical contact sensing, and obtain two-dimensional OCT images via M-to-B-mode conversion. Materials and Methods: We designed and developed ultrasmall, manually scannable, side-and forward-viewing single fiber-optic probes that can capture M-mode OCT data. Side-viewing M-mode OCT probes were incorporated into brush biopsy devices designed to harvest the microbiome and forward-viewing M-mode OCT probes were integrated into devices that measure intestinal potential difference (IPD). The M-mode OCT probe-coupled devices were utilized in the GI tract in six unsedated patients in vivo. M-mode data were converted into B-mode images using an M-to-B-mode conversion algorithm. The effectiveness of physical contact sensing by the M-mode OCT probes was assessed by comparing the variances of the IPD values when the probe was in physical contact with the tissue versus when it was not. The capacity of forward-and side-viewing M-mode OCT probes to produce high-quality B-mode images was compared by computing the percentages of the M-to-B-mode images that showed close contact between the probe and the luminal surface. Passively scanned M-to-B-mode images were qualitatively compared to B-mode images obtained by mechanical scanning OCT tethered capsule endomicroscopy (TCE) imaging devices.

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Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices

Cited by 4 publications

References 46 publications

The LMIT: Light-mediated minimally-invasive theranostics in oncology

The LMIT: Light-mediated minimally-invasive theranostics in oncology

Study on the application of optical coherence microscopy in Hirschsprung's disease

Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices

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